Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases

Khot, Kartik Bhairu; Gopan, Gopika; Bandiwadekar, Akshay; Jose, Jobin

doi:10.1016/j.arr.2022.101806

Cited by 14 publications

(4 citation statements)

References 130 publications

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“…Liposomes are also used in treating neurodegenerative diseases such as Alzheimer's and Parkinson's, not only for their properties but also for their ability to cross the blood-brain barrier (BBB) [59,60] easily. Therefore, given the inherent complexity of neurological disorders such as Alzheimer's disease, which involve various mechanisms and affect multiple brain regions, the choice of liposomes offers a precise and targeted delivery approach [61].…”

Section: Functionalization Of Liposomesmentioning

confidence: 99%

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

M. Oliveira,

M.F. Duarte,

de L. Lins

et al. 2024

Liposomes - A Modern Approach in Research [Working Title]

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Liposomes are microscopic lipid-based vesicles that have emerged as a promising vehicle for transporting therapeutic agents with precision and efficiency. From enhanced drug bioavailability to targeted delivery, combining nanomaterials and liposomes offers a transformative approach to therapeutic interventions. Encapsulating nanomaterials with drugs in liposomes holds immense significance as it enhances precision, efficiency, and targeted delivery, revolutionizing therapeutic interventions in medicine. This chapter delves into the unique properties of nanomaterials encapsulated within liposomes, examining their potential to revolutionize medicine. In addition, it highlights key advancements, challenges, and prospects in this dynamic and rapidly evolving field, providing readers with a comprehensive understanding of the revolutionary impact on the future of medicinal drugs.

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Section: Functionalization Of Liposomesmentioning

confidence: 99%

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

M. Oliveira,

M.F. Duarte,

de L. Lins

et al. 2024

Liposomes - A Modern Approach in Research [Working Title]

View full text Add to dashboard Cite

show abstract

“…Similarly, Ye et al used liposomes to deliver NADH to mouse models, achieving a 25% increase in the cellular NAD+/NADH ratio and improved therapeutic efficacy in sepsis [82]. These and numerous other studies [83][84][85] highlight the remarkable versatility and efficiency of liposomes as drug carriers. This versatility stems from their ability to encapsulate both water-soluble and fatsoluble molecules, enhancing stability and bioavailability [86].…”

Section: Optimizing Bioavailability: Delivery Strategiesmentioning

confidence: 99%

Nicotinamide Mononucleotide: Deciphering Metabolic Complexities for Improved Health Outcomes

Benjamin,

Crews

2024

Preprint

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Nicotinamide mononucleotide (NMN), a key NAD+ precursor, exhibits distinct metabolic characteristics and potential health benefits. Recent investigations underscore the pivotal role of gut bacteria and specialized uptake mechanisms in NMN metabolism. While human trials demonstrate NMN's safety and promising health outcomes, challenges persist. Variability in results is likely influenced by lifestyle, health conditions, and individual genetic and gut microbiota differences. Understanding how these factors affect NMN metabolism is crucial for personalized approaches and maximizing NMN's potential. Advances in delivery systems show promise for enhancing NMN bioavailability, but further understanding of optimal NAD+ levels and reliable measures of NMN's effects is necessary. This comprehensive approach is key to optimizing NMN's impact on human health and longevity.

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“…Liposomes are extensively regarded and investigated as lipid-based drug delivery vehicles, not only due to the fundamental raw material for their manufacture, phospholipids, is an inherent element in human cells, making them friendly and non-immunogenic, but also since they can be manufactured as nanoscale particles, making them simpler to cross intrinsic limitations like blood vessel barriers and cellular membranes. In addition to antibacterial medication delivery, they are now employed in a variety of purposes, including as the treatment of cancer [81][82][83], eye illnesses [84,85], and neurodegenerative diseases [86,87].…”

Section: Lipid-based Nano-formulations As Antibacterial Theranosticsmentioning

confidence: 99%

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Jiang¹,

Ding²,

Liu³

2023

Theranostics

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Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined “theranostic” approaches to more effectively treating bacterial infections.

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Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases

Cited by 14 publications

References 130 publications

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

Nicotinamide Mononucleotide: Deciphering Metabolic Complexities for Improved Health Outcomes

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

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