Current Advances in Epigenetic Modification and Alteration during Mammalian Ovarian Folliculogenesis

Pan, Zengxiang; Zhang, Jinbi; Li, Qifa; Li, Yinxia; Shi, Fangxiong; Xie, Zhihua; Liu, Honglin

doi:10.1016/j.jgg.2012.02.004

Cited by 44 publications

(25 citation statements)

References 103 publications

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“…[21,22] Studies have suggested that DNA methylation regulation exists in ovarian follicle growth and atresia. [23] YAP1, known as a pivotal transcriptional co-activator of Hippo pathway, participates in many signaling pathways that regulate organic morphology, including ovary enlargement that is one of the major manifestations of PCOS. [24,25] YAP1 could combine with a series of transcription factors and act as a modulator through phosphorylation.…”

Section: Discussionmentioning

confidence: 99%

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

et al. 2017

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Background:DNA methylation modification has been proved to influence the phenotype of polycystic ovary syndrome (PCOS). Genome-wide association studies (GWAS) demonstrate that yes-associated protein (YAP1) genetic sites are associated with PCOS. The study aims to detect the methylation status of YAP1 promoter in ovary granulosa cells (GCs) of PCOS patients and explore novel therapeutic targets for PCOS.Methods:Randomized controlled trial was applied and a total of 72 women were included in the study, including 36 cases of PCOS patients and 36 cases of health controls. Ovary GCs were extracted from in vitro fertilization embryo transfer. Methylation status of YAP1 promoter was detected by bisulfite sequencing PCR (BSP). Protein and mRNA expression of YAP1 were measured by western blotting and real-time quantitate PCR.Results:Overall methylation level of YAP1 promoter region from PCOS group was significantly lower than that from control group. CpG sites analysis revealed that 12 sites (−443, −431, −403, −371, −331, −120, −49, −5, +1, +9, +15, +22) were significantly hypomethylated in women with PCOS (P < 0.05). A significant upregulation of YAP1 mRNA and protein expression levels was observed. Testosterone concentration could alleviate the methylation status and demonstrate obvious dose–dependent relation.Conclusion:Our research achievements manifest that hypomethylation of YAP1 promoter promotes the YAP1 expression, which plays a key role in the pathogenesis and accelerate PCOS.

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Section: Discussionmentioning

confidence: 99%

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

et al. 2017

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“…44 During folliculogenesis, primordial germ cells entrance into the genital ridge around E9.5-E11.5 is marked by accumulation of H3K9me3 and H3K27me3, whereas a more restricted peak in H3K4me3 occurs at E10.5. 45 This suggests that follicle maturation is marked by a period of poised chromatin domains containing active and repressive histone marks as part of a differentiation gene expression program. In the present study, we observe that the Six2 + cells are enriched in active and repressive histone Figure 4.…”

Section: Discussionmentioning

confidence: 99%

In situ histone landscape of nephrogenesis

et al. 2013

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“…Subsequently, oogonia enter meiosis and become arrested in the diplotene stage of meiosis I, at which point they are referred to as primary oocytes (Hunt & Hassold 2008, Pepling 2012. Concomitant with the oogonia-to-oocyte transition is breakdown of cysts and the freeing of individual oocytes to form primordial follicles (Pan et al 2012). Breakdown of cysts and the establishment of the primordial follicle pool occur from postnatal (P) day 1 to P4 in rodents (Rajah et al 1992, Pepling & Spradling 2001.…”

Section: Establishment Of Female Reproductive Function: a Brief Overviewmentioning

confidence: 99%

“…Thus in addition to the development and differentiation of germ and somatic cells being vulnerable to early-life insults, adversity may equally (or simultaneously) result in stable changes to the epigenotype of germ cells (Pan et al 2012), having long-term implications for future generations (Fig. 1).…”

Section: Establishment Of Female Reproductive Function: a Brief Overviewmentioning

confidence: 99%

Early-life nutritional effects on the female reproductive system

Chan

Tsoulis

Sloboda³

2014

Journal of Endocrinology

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There is now considerable epidemiological and experimental evidence indicating that early-life environmental conditions, including nutrition, affect subsequent development in later life. These conditions induce highly integrated responses in endocrine-related homeostasis, resulting in persistent changes in the developmental trajectory producing an altered adult phenotype. Early-life events trigger processes that prepare the individual for particular circumstances that are anticipated in the postnatal environment. However, where the intrauterine and postnatal environments differ markedly, such modifications to the developmental trajectory may prove maladaptive in later life. Reproductive maturation and function are similarly influenced by early-life events. This should not be surprising, because the primordial follicle pool is established early in life and is thus vulnerable to early-life events. Results of clinical and experimental studies have indicated that early-life adversity is associated with a decline in ovarian follicular reserve, changes in ovulation rates, and altered age at onset of puberty. However, the underlying mechanisms regulating the relationship between the early-life developmental environment and postnatal reproductive development and function are unclear. This review examines the evidence linking early-life nutrition and effects on the female reproductive system, bringing together clinical observations in humans and experimental data from targeted animal models.

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Current Advances in Epigenetic Modification and Alteration during Mammalian Ovarian Folliculogenesis

Cited by 44 publications

References 103 publications

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

In situ histone landscape of nephrogenesis

Early-life nutritional effects on the female reproductive system

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