Current advances in intraosseous infusion – A systematic review

Weiser, Giora; Hoffmann, Yoav; Galbraith, Roger; Shavit, Itai

doi:10.1016/j.resuscitation.2011.07.020

Cited by 58 publications

(45 citation statements)

References 31 publications

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“…(6) The antibody-transduced detection system using immuno-PCR style tagging with DNA, where complement is engineered to form a Y-transducer, or related, detection system [46]. …”

Section: Methods and Resultsmentioning

confidence: 99%

“…A single molecule’s blockading interaction upon capture in an ion channel can be self-modulating upon capture (i.e., without a dominant interaction state), and this has been found in a number of experiments [34-46]. The mechanism of interaction involves transient chemical bond formation between transducer and protein, where each bound state between transducer and channel imprints on the surrounding ionic current flow to provide a fixed level which then transitions to a different fixed level upon the bond dissociation or transitions to a different bound state.…”

Section: Introductionmentioning

confidence: 97%

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The NTD Nanoscope: potential applications and implementations

2011

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BackgroundNanopore transduction detection (NTD) offers prospects for a number of highly sensitive and discriminative applications, including: (i) single nucleotide polymorphism (SNP) detection; (ii) targeted DNA re-sequencing; (iii) protein isoform assaying; and (iv) biosensing via antibody or aptamer coupled molecules. Nanopore event transduction involves single-molecule biophysics, engineered information flows, and nanopore cheminformatics. The NTD Nanoscope has seen limited use in the scientific community, however, due to lack of information about potential applications, and lack of availability for the device itself. Meta Logos Inc. is developing both pre-packaged device platforms and component-level (unassembled) kit platforms (the latter described here). In both cases a lipid bi-layer workstation is first established, then augmentations and operational protocols are provided to have a nanopore transduction detector. In this paper we provide an overview of the NTD Nanoscope applications and implementations. The NTD Nanoscope Kit, in particular, is a component-level reproduction of the standard NTD device used in previous research papers.ResultsThe NTD Nanoscope method is shown to functionalize a single nanopore with a channel current modulator that is designed to transduce events, such as binding to a specific target. To expedite set-up in new lab settings, the calibration and troubleshooting for the NTD Nanoscope kit components and signal processing software, the NTD Nanoscope Kit, is designed to include a set of test buffers and control molecules based on experiments described in previous NTD papers (the model systems briefly described in what follows). The description of the Server-interfacing for advanced signal processing support is also briefly mentioned.ConclusionsSNP assaying, SNP discovery, DNA sequencing and RNA-seq methods are typically limited by the accuracy of the error rate of the enzymes involved, such as methods involving the polymerase chain reaction (PCR) enzyme. The NTD Nanoscope offers a means to obtain higher accuracy as it is a single-molecule method that does not inherently involve use of enzymes, using a functionalized nanopore instead.

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“…(6) The antibody-transduced detection system using immuno-PCR style tagging with DNA, where complement is engineered to form a Y-transducer, or related, detection system [46]. …”

Section: Methods and Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

The NTD Nanoscope: potential applications and implementations

2011

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“…Studies indicate that this device is superior to other devices as it is easy to use and holds a high success rate of insertion among users [11, 33]. …”

Section: Discussionmentioning

confidence: 99%

Intraosseous access can be taught to medical students using the four-step approach

et al. 2017

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BackgroundThe intraosseous (IO) access is an alternative route for vascular access when peripheral intravascular catheterization cannot be obtained. In Denmark the IO access is reported as infrequently trained and used. The aim of this pilot study was to investigate if medical students can obtain competencies in IO access when taught by a modified Walker and Peyton’s four-step approach.MethodsNineteen students attended a human cadaver course in emergency procedures. A lecture was followed by a workshop. Fifteen students were presented with a case where IO access was indicated and their performance was evaluated by an objective structured clinical examination (OSCE) and rated using a weighted checklist. To evaluate the validity of the checklist, three raters rated performance and Cohen’s kappa was performed to assess inter-rater reliability (IRR). To examine the strength of the overall IRR, Randolph’s free-marginal multi rater kappa was used.ResultsA maximum score of 15 points was obtained by nine (60%) of the participants and two participants (13%) scored 13 points with all three raters. Only one participant failed more than one item on the checklist. The expert rater rated lower with a mean score of 14.2 versus the non-expert raters with mean 14.6 and 14.3. The overall IRR calculated with Randolph’s free-marginal multi rater kappa was 0.71.ConclusionThe essentials of the IO access procedure can be taught to medical students using a modified version of the Walker and Peyton’s four-step approach and the checklist used was found reliable.

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“…The intraosseous route can replace the peripheral venous route in emergency situations, as in the management of severe trauma [1,2]. This alternative, however, carries risks.…”

mentioning

confidence: 99%

“…The intraosseous device used was not specifically designed for sternal use (Jamshidi trocar 1 ). The trocar was chosen because it is versatile, quickly and easily inserted, and has a high insertion success rate [2]. This catheter was properly positioned during the initial resuscitation, as indicated by the clinical efficacy of treatment administered.…”

mentioning

confidence: 99%