Current and Emerging Strategies for Prediction and Diagnosis of Prelabour Rupture of the Membranes: A Narrative Review

Ghafoor, Saadia

doi:10.21315/mjms2021.28.3.2

Cited by 11 publications

(5 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to the lack of accurate and early prediction of the outbreak window, we can hardly intervene early in the occurrence of premature rupture of membranes [ 39 , 40 ], and only empiric treatment after the occurrence of the disease can maximize the maternal and fetal outcomes; as a classical obstetric practice, there have been no significant changes for the last many years [ 4 ]. Therefore, we are committed to finding the key to initiate premature rupture of membranes.…”

Section: Discussionmentioning

confidence: 99%

Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes

Huang,

Ran,

Chen

et al. 2024

Analytical Cellular Pathology

View full text Add to dashboard Cite

Premature rupture of membrane (PROM) refers to the rupture of membranes before the onset of labor which increases the risk of perinatal morbidity and mortality. Recently, circular RNAs (circRNAs) have emerged as promising regulators of diverse diseases. However, the circRNA expression profiles and potential circRNA–miRNA–mRNA regulatory mechanisms in PROM remain enigmatic. In this study, we displayed the expression profiles of circRNAs and mRNAs in plasma and fetal membranes of PROM and normal control (NC) groups based on circRNA microarray, the Gene Expression Omnibus database, and NCBI’s Sequence Read Archive. A total of 1,459 differentially expressed circRNAs (DECs) in PROM were identified, with 406 upregulated and 1,053 downregulated. Then, we constructed the circRNA–miRNA–mRNA network in PROM, encompassing 22 circRNA–miRNA pairs and 128 miRNA–mRNA pairs. Based on the analysis of gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and gene set enrichment analysis (GSEA), DECs were implicated in immune-related pathways, with certain alterations persisting even postpartum. Notably, 11 host genes shared by DECs of fetal membrane tissue and prenatal plasma in PROM were significantly implicated in inflammatory processes and extracellular matrix regulation. Our results suggest that structurally stable circRNAs may predispose to PROM by mediating systemic immune imbalances, including peripheral leukocyte disorganization, local immune imbalance at the maternal–fetal interface, and local collagen disruption. This is the first time to decipher a landscape on circRNAs of PROM, reveals the pathogenic cause of PROM from the perspective of circRNA, and opens up a new direction for the diagnosis and treatment of PROM.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes

Huang,

Ran,

Chen

et al. 2024

Analytical Cellular Pathology

View full text Add to dashboard Cite

show abstract

“…16 Second, multiple gestations were not always an appropriate candidate for vaginal delivery. 17 Third, premature rupture of the membranes was a common indication for labor induction, 1 yet approximately 70% of women with ruptured membranes had spontaneous labor within 24 h. 18,19 In light of all these considerations, we have selectively enrolled studies with patients who were at least late preterm (GA ≥34 weeks), had singleton pregnancies and had intact membranes before labor induction. Non-randomized clinical trials, pregnant women with GA ≥36 weeks.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Oxytocin and vaginal dinoprostone in labor induction: A systematic review and meta‐analysis

Chang,

Li,

Ding

2024

Intl J Gynecology & Obste

View full text Add to dashboard Cite

BackgroundThe comparison between prostaglandin E2 (PGE2) and oxytocin and for induction of labor (IOL) remains controversial.ObjectiveThe present study aimed to determine the safety and efficacy of these two agents in IOL.Search StrategyPubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov. from the establishment of the database to April 23, 2023.Selection CriteriaA search was conducted with keywords “labor, induction, prostaglandin E2/PGE2/dinoprostone, and oxytocin”. Only randomized clinical trials comparing oxytocin and vaginal dinoprostone in women who were at least late preterm (gestational age [GA] ≥34 weeks), singleton pregnant, and had intact membranes were enrolled for further meta‐analysis.Data Collection and AnalysisWe conducted both a descriptive analysis and a meta‐analysis. In the meta‐analysis, we utilized the Mantel–Haenszel random effects model to analyze dichotomous data, employing the relative risk (RR) as the effect measure along with 95% confidence intervals (CIs). The study quality was evaluated using Cochrane Collaboration's risk of bias assessment tool (RoB 2). A random‐effects model was applied for the meta‐analysis.Main ResultsAfter screening 3303 articles from five databases, a total of nine randomized controlled studies composed of 1071 patients were included. Our analysis included 534 patients in the PGE2 group and 537 patients in the oxytocin group. The pooled estimate of vaginal deliveries following PGE2 induction stood at 84.2%, while after oxytocin induction, it was 79.8%. The meta‐analysis showed no statistical difference between the two groups in terms of the rate of vaginal delivery (pooled RR, 1.05; 95% CI: 0.95–1.16; P value for Q, 0.001; I2, 71.14%), cesarean section (pooled RR, 0.84; 95% CI: 0.52–1.35; P value for Q, 0.007; I2, 61.69%) and induction‐delivery interval (pooled standard mean difference, 0.09; 95% CI: −0.67 to 0.85; P value for Q, 0.000; I2, 96.45%). Since the results for fetal distress and uterine hyperstimulation were consistent across all enrolled studies, no further meta‐analysis was conducted.ConclusionsWhen amalgamating the available literature, it implies that oxytocin was found to have similar effects as PGE2 on delivery outcomes and safety concerns in pregnant women with GA ≥36 weeks. Although the uterine cervix was unfavorable, both low and high doses of oxytocin were feasible for IOL.

show abstract

“…ПРПО является одной из наиболее актуальных проблем современного акушерства. По данным литературы, ПРПО осложняет течение 3-4% всех беременностей и до 40% -недоношенных [1], повышает риск возникновения перинатальных и материнских осложнений [2].…”

Section: Introductionunclassified

Comparative evaluation of test systems for determining premature rupture of membranes

2023

View full text Add to dashboard Cite

Introduction. Preterm premature rupture of the membranes (PPROM) is one of the most common pregnancy complications. PPROM as а cause of infectious complications poses the greatest danger with increasing duration of period without amniotic fluid (i.e., watchful waiting) in full-term pregnancy.Aim. Comparative evaluation of test systems for the diagnosis of premature rupture of the membranes (PROM) based on the determination of the pH of the vaginal contents, the detection of placental alpha macroglobulin-1 (PAMG) or insulin-like growth factor-binding protein 1 (IGFBP-1).Materials and methods. The study included 52 patients at 22–41 weeks of gestation in whom, according to the clinical examination, it is impossible to exclude/confirm PROM. All women were examined for the detection of PROM using test systems: nitrazine pH test, immunochromatographic test for the detection of IGFBP-1 or PAMG-1. The sensitivity, specificity, accuracy, predictive value of positive and negative results were calculated.Results. As a result of the study, premature rupture of the membranes was confirmed in 25 cases, and this diagnosis was excluded in 27 cases. In three observations, additional observation and examination were required due to the questionable interpretation of the result due to a test error. Sensitivity and specificity were 64.0 and 66.7% for the nitrazine test, 95.8 and 92.3% for IGFBP-1, and 95.8 and 96.3% for PAMG-1.Conclusion. The nitrazine test has low sensitivity and specificity, therefore, for the diagnosis of PROM, test systems based on the determination of PAMG-1 and IGFBP-1 should be used, which improves the quality of diagnosis, reduces the risk of complications and ensures the timely start of a set of measures appropriate to the clinical situation. A negative test result avoids unnecessary hospitalization and unnecessary interventions, which is important both from a medical and economic point of view.

show abstract

Current and Emerging Strategies for Prediction and Diagnosis of Prelabour Rupture of the Membranes: A Narrative Review

Cited by 11 publications

References 92 publications

Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes

Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes

Oxytocin and vaginal dinoprostone in labor induction: A systematic review and meta‐analysis

Comparative evaluation of test systems for determining premature rupture of membranes

Contact Info

Product

Resources

About