Current and emerging treatment modalities for bacterial rhinosinusitis in adults: a comprehensive review

Matera, Maria Gabriella; Rinaldi, Barbara; Novellis, Vito de; Rogliani, Paola; Cazzola, Mario

doi:10.1080/14656566.2022.2147825

Cited by 2 publications

(1 citation statement)

References 66 publications

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“…CRS significantly reduces patients’ quality of life and heavily weighs on the US health care system. CRS is often treated with frequent prescription of antibiotics (~20% of antibiotic prescriptions in adults), which can promote the selection of resistant bacterial strains [ 172 , 173 , 174 , 175 ]. Overall, it is estimated that the management of CRS accounts for over USD 8 billion in direct health care costs in the US [ 176 ], and these costs increase in cases of increased antibiotic therapy failures [ 177 ].…”

Section: Interactions Of T2rs With Pseudomonas Aeruginosa ...mentioning

confidence: 99%

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Kouakou

Lee

2023

Microorganisms

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Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively) were originally identified in type II taste cells on the tongue, where they signal perception of bitter and sweet tastes, respectively. Over the past ~15 years, taste receptors have been identified in cells all over the body, demonstrating a more general chemosensory role beyond taste. Bitter and sweet taste receptors regulate gut epithelial function, pancreatic β cell secretion, thyroid hormone secretion, adipocyte function, and many other processes. Emerging data from a variety of tissues suggest that taste receptors are also used by mammalian cells to “eavesdrop” on bacterial communications. These receptors are activated by several quorum-sensing molecules, including acyl-homoserine lactones and quinolones from Gram-negative bacteria such as Pseudomonas aeruginosa, competence stimulating peptides from Streptococcus mutans, and D-amino acids from Staphylococcus aureus. Taste receptors are an arm of immune surveillance similar to Toll-like receptors and other pattern recognition receptors. Because they are activated by quorum-sensing molecules, taste receptors report information about microbial population density based on the chemical composition of the extracellular environment. This review summarizes current knowledge of bacterial activation of taste receptors and identifies important questions remaining in this field.

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Section: Interactions Of T2rs With Pseudomonas Aeruginosa ...mentioning

confidence: 99%

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Kouakou

Lee

2023

Microorganisms

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Antibacterial therapy in patients with acute sinusitis

Kochetkov,

Shchennikova,

Shabanova

2024

Medicinskij sovet

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The prevalence of the acute sinusitis in ENT practice is very high. The current prevalence in Russian Federation is roughly estimated at 6 to 15%, and accounts for about 10 million cases a year. The incidence of acute sinusitis increases in autumn and early spring and decreases in the summer. Most cases of acute sinusitis are of a viral etiology, but it can also arise from bacterial infection, allergies, or injuries. The disease is characterized by swelling of the nasal mucous membrane, nasal blockage and discharge. Typically, the duration of acute inflammation of the paranasal sinuses averages about 4 weeks. In case of the inappropriate treatment, the inflammatory process can spread to adjacent anatomical structures – to the orbit, ear, or brain, resulting in serious, sometimes life-threatening complications. Over the last 10 years, the resistance of pathogenic flora to antimicrobial agents has greatly increased due to the unjustifiability and irrationality of their use. The purpose of this review was to analyze the effectiveness and safety of the antibiotic therapy for acute rhinosinusitis. The paper discusses the etiology, pathogenesis, and characteristics of the acute sinusitis. It presents the features of the most used drugs, with special attention to the comparative assessment of their therapeutic effectiveness compared to other antibiotics, as well as determining the optimal schemes for their use within the framework of modern clinical protocols. A description of a clinical case of acute sinusitis and a treatment regimen with Cefixime EXPRESS is presented.

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Current and emerging treatment modalities for bacterial rhinosinusitis in adults: a comprehensive review

Cited by 2 publications

References 66 publications

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Antibacterial therapy in patients with acute sinusitis

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