Current and future nanoparticle vaccines for COVID-19

Vu, Mai N.; Kelly, Hannah G.; Kent, Stephen J.; Wheatley, Adam K.

doi:10.1016/j.ebiom.2021.103699

Cited by 73 publications

(55 citation statements)

References 88 publications

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“…Having these cargoes loaded on the nanocarrier surface can lead to potent immunogenicity, while the encapsulated active agents at the core can stay protected and thereby demonstrate controlled delivery. [ 179 ] The first two vaccines approved for treating COVID‐19 are comprised of lipid nanocarriers with encapsulate mRNA encoding engineered spike (S) protein as active material. [ 181 , 182 ] However, polymers such as, PLGA, polyethyleneimine, chitosan, etc., have been widely used to develop nanocarriers to deliver vaccines for various other corona viruses.…”

Section: Various Polymeric Nanocarriers For Drug Deliverymentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC-associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design-based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever-increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design-based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi-stimuli-responsive and multi-drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area.

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Section: Various Polymeric Nanocarriers For Drug Deliverymentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 (coronavirus disease 2019). The virus attachment to the host cell occurs with the viral spike (S) protein, and it also serves as the impassable pursuit for drug development against this deadly virus [162]. Plants contain natural products such as flavonoids, alkaloids, steroids, saponins, tannins, coenzymes, etc., that are present in abundance and are found in different parts of a plant such as the leaves, flowers, roots, stem, shoots, bark, and fruits as well in seeds.…”

Section: Plant-based Nanoparticles (Pbnps) As a Promising Nanomedicin...mentioning

confidence: 99%

Recent Advancements in Plant-Derived Nanomaterials Research for Biomedical Applications

et al. 2022

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Engineering, physics, chemistry, and biology are all involved in nanotechnology, which comprises a wide variety of multidisciplinary scientific field devices. The holistic utilization of metallic nanoparticles in the disciplines of bio-engineering and bio-medicine has attracted a great deal of attention. Medical nanotechnology research can offer immense health benefits for humans. While the advantages of developing nanomaterials have been well documented, it is precisely apparent that there are still some major issues that remain unattended to those need to be resolved immediately so as to ensure that they do not adversely affect living organisms in any manner. The existence of nanoparticles gives them particular value in biology and materials science, as an emerging scientific field, with multiple applications in science and technology, especially with numerous frontiers in the development of new materials. Presented here is a review of recent noteworthy developments regarding plant-derived nanomaterials and their use in the development of medicine and biomedical applications around the world.

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“… SARS-CoV-2 S protein consists of three identical chains with different colors of yellow that demonstrate S1 domains, and cyan that demonstrate S2 domains. Reproduced with permission from [ 108 ]. Copyright Elsevier, 2021.…”

Section: Figurementioning

confidence: 99%

Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment

et al. 2022

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Following the announcement of the outbreak of COVID-19 by the World Health Organization, unprecedented efforts were made by researchers around the world to combat the disease. So far, various methods have been developed to combat this “virus” nano enemy, in close collaboration with the clinical and scientific communities. Nanotechnology based on modifiable engineering materials and useful physicochemical properties has demonstrated several methods in the fight against SARS-CoV-2. Here, based on what has been clarified so far from the life cycle of SARS-CoV-2, through an interdisciplinary perspective based on computational science, engineering, pharmacology, medicine, biology, and virology, the role of nano-tools in the trio of prevention, diagnosis, and treatment is highlighted. The special properties of different nanomaterials have led to their widespread use in the development of personal protective equipment, anti-viral nano-coats, and disinfectants in the fight against SARS-CoV-2 out-body. The development of nano-based vaccines acts as a strong shield in-body. In addition, fast detection with high efficiency of SARS-CoV-2 by nanomaterial-based point-of-care devices is another nanotechnology capability. Finally, nanotechnology can play an effective role as an agents carrier, such as agents for blocking angiotensin-converting enzyme 2 (ACE2) receptors, gene editing agents, and therapeutic agents. As a general conclusion, it can be said that nanoparticles can be widely used in disinfection applications outside in vivo. However, in in vivo applications, although it has provided promising results, it still needs to be evaluated for possible unintended immunotoxicity. Reviews like these can be important documents for future unwanted pandemics.

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Current and future nanoparticle vaccines for COVID-19

Cited by 73 publications

References 88 publications

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Recent Advancements in Plant-Derived Nanomaterials Research for Biomedical Applications

Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment

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