2023
DOI: 10.3390/pharmaceutics15010162
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Current and Future Therapeutic Approaches of Exocrine Pancreatic Insufficiency in Children with Cystic Fibrosis in the Era of Personalized Medicine

Abstract: This review presents current updates of pancreatic enzyme replacement therapy in children with cystic fibrosis based on literature published in the last decade and some special considerations regarding pancreatic enzyme replacement therapy in the era of new therapies, such as cystic fibrosis transmembrane conductance regulator modulator therapies. Few articles evaluate the efficacy of pancreatic enzyme replacement therapy in the pediatric population, and most studies also included children and adults with cyst… Show more

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Cited by 7 publications
(6 citation statements)
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“…The first pancreatic enzyme supplements came in the form of powder and tablets. However, they were only partially effective in alleviating EPI signs in people 46 . Pancreatic enzymes operate in the alkaline environment of the duodenum.…”
Section: Pancreatic Enzyme Replacement Therapymentioning
confidence: 99%
“…The first pancreatic enzyme supplements came in the form of powder and tablets. However, they were only partially effective in alleviating EPI signs in people 46 . Pancreatic enzymes operate in the alkaline environment of the duodenum.…”
Section: Pancreatic Enzyme Replacement Therapymentioning
confidence: 99%
“…Abdominal bloating, greasy stools, flatulence, and inadequate weight gain are all clinical signs of pancreatic insufficiency [ 40 ]. Individuals suffering from cystic fibrosis have reduced exocrine enzyme secretion, which leads to maldigestion [ 41 ]. This causes a range of symptoms, such as steatorrhea, deficiencies in fat-soluble vitamins, and failure to thrive.…”
Section: Introductionmentioning
confidence: 99%
“…The CFTR’s physiological expression and functionality are crucial in endocrine tissues for proper electrochemical exchanges and regulatory routes. [ 13 ]…”
Section: Introductionmentioning
confidence: 99%