Current and Potential Applications of Simultaneous DSC-FTIR Microspectroscopy for Pharmaceutical Analysis

Lin, Shan‐Yang

doi:10.38212/2224-6614.3345

Cited by 5 publications

(2 citation statements)

References 140 publications

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“…Changes in FTIR spectra in conjunction with endo or exothermic DSC peaks make it possible to infer the nature of polymorphic transitions, distinguish sublimation from degradation, study intramolecular cyclization processes associated with lactam or anhydride formation and quickly identify co-crystals that form in physical mixtures of API and coformer during heating. A comprehensive discussion of examples of the application of DSC–FTIR microspectroscopy for rapid examination of active substances’ stability in the solid state [ 95 ], screening and detection of pharmaceutical co-crystals [ 96 ] and potential application for pharmaceutical analysis [ 97 ] is presented in the review papers.…”

Section: Simultaneous Dsc Measurementsmentioning

confidence: 99%

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Wesołowski

Leyk

2023

Pharmaceutics

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Reliable interpretation of the changes occurring in the samples during their heating is ensured by using more than one measurement technique. This is related to the necessity of eliminating the uncertainty resulting from the interpretation of data obtained by two or more single techniques based on the study of several samples analyzed at different times. Accordingly, the purpose of this paper is to briefly characterize thermal analysis techniques coupled to non-thermal techniques, most often spectroscopic or chromatographic. The design of coupled thermogravimetry (TG) with Fourier transform infrared spectroscopy (FTIR), TG with mass spectrometry (MS) and TG with gas chromatography/mass spectrometry (GC/MS) systems and the principles of measurement are discussed. Using medicinal substances as examples, the key importance of coupled techniques in pharmaceutical technology is pointed out. They make it possible not only to know precisely the behavior of medicinal substances during heating and to identify volatile degradation products, but also to determine the mechanism of thermal decomposition. The data obtained make it possible to predict the behavior of medicinal substances during the manufacture of pharmaceutical preparations and determine their shelf life and storage conditions. Additionally, characterized are design solutions that support the interpretation of differential scanning calorimetry (DSC) curves based on observation of the samples during heating or based on simultaneous registration of FTIR spectra and X-ray diffractograms (XRD). This is important because DSC is an inherently non-specific technique. For this reason, individual phase transitions cannot be distinguished from each other based on DSC curves, and supporting techniques are required to interpret them correctly.

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Section: Simultaneous Dsc Measurementsmentioning

confidence: 99%

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Wesołowski

Leyk

2023

Pharmaceutics

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“…cement, gypsum and clays and later in the studies of biomolecules like proteins or biomembranes [ 3 ]. Nowadays, this technique is also widely used in the routine analysis of drugs compounds [ 4 ], biomolecules and nanosized materials [ 5 ], energetic materials [ 6 ] as well as petroleum products [ 7 ]. Gradually over time, food research using DSC techniques has undergone intensive development, mainly focused on the study of protein denaturation and protein unfolding [ 8 ], starch gelatinization or retrogradation in cereal based products technology, evaluation of physical characteristics and authentication of oils and fats based on their thermal behaviors like the phase transition of melting and crystallization, as well as oxidative stability.…”

Section: Introductionmentioning

confidence: 99%

Differential scanning calorimetry for authentication of edible fats and oils - What can we learn from the past to face the current challenges?

Islam¹,

Bełkowska²,

Konieczny³

et al. 2022

Journal of Food and Drug Analysis

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Fats and oils authentication has become an important issue recently, due to the growing interest in consumption of cold-pressed oils. Therefore, it is becoming more and more difficult to maintain official control over the growing assortment of new cold-pressed oils. Authenticity of plant oils is also an important issue for religious or cultural reasons. This review article focuses on the application of differential scanning calorimetry (DSC) in the field of assessing authenticity of various fats and oils (e.g. olive oil, palm oil, confectionery fats, butter). Extra virgin olive oil (EVOO) is the most comprehensively tested oil by means of the DSC technique in terms of the authenticity of origin as well as the adulteration with foreign oils. In most of the studies on DSC applicability for authentication, crystallization and melting curves were analyzed by the conventional DSC, although other modified DSC methods were also applied, such as isothermal freezing, modulated temperature DSC (MT-DSC) and fast DSC. However, the most promising are the melting profiles, which, due to the complexity of transitions, need advanced chemometric tools as well as tools for peaks deconvolution. The future prospect of using DSC in the authenticity assessment lies also in the use of DSC techniques along with other complementary chromatographic or spectroscopic techniques.

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Optical Sensors

Faramawy

2023

Handbook of Nanosensors

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Current and Potential Applications of Simultaneous DSC-FTIR Microspectroscopy for Pharmaceutical Analysis

Cited by 5 publications

References 140 publications

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Differential scanning calorimetry for authentication of edible fats and oils - What can we learn from the past to face the current challenges?

Optical Sensors

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