Current Approach for the Treatment of Parkinson’s Disease by Simvastatin: A Review

Abstract

Parkinson disease has become one of the common life-threatening health problem in the world. But the pathogenesis and related mechanisms are still unclear. Current therapy of Parkinson's disease (PD) is not satisfactory, which is the use of combinations of levodopa with other dopaminergic agonist but it is symptomatic in nature and does not slow down the disease course. Many studies have revealed that statins which are used as an antihyperlipidemic drug and have the ability to protect the dopaminergic cells from neurodegeneration. They have anti-inflammatory, suppression of oxidative stress, anticoagulation, angiogenesis actions. So in this review, we are trying to find out the actions of statins on Parkinson disease.