Current Approaches to COPD in 2019

Corlăteanu, Alexandru

doi:10.2174/1573398x1502191014114230

Cited by 1 publication

(2 citation statements)

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“…Chronic obstructive pulmonary disease (COPD), according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 report, is considered a rising public health problem with a significant socio-economic burden [1][2][3][4]. The magnitude of the condition is statistically suggested by its fourth place in the structure of death causes worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…COPD complications increase the risk of death due to other comorbidities; therefore, the health impact of COPD may be underestimated, considering that 50% of mortality in COPD patients is caused by non-respiratory diseases [5,11,12]. Specific to COPD in geriatrics are: (1) higher prevalence in the elderly; (2) higher severity of the disease; (3) a silent clinical picture in the early stages, with the disease being unrecognized and untreated until it progresses to a more severe degree; (4) the association with a large number of comorbidities (average of 9); (5) a higher mortality rate; (6) reduced therapeutic efficacy and (7) a significant quality of life impact [13][14][15][16][17][18]. Exacerbation of COPD in the elderly consisted of aggravation of the disease, the apparition of other symptoms and worsening of the pre-existing ones, a significant decline in functional and cognitive performance, a reduction in quality of life, and a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

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The impact of secondary pulmonary hypertension in elderly patients with chronic obstructive pulmonary disease

Luca¹,

Bodrug²

2023

MJHS

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Chronic obstructive pulmonary disease (COPD) is considered an important disease in the structure of morbidity and mortality and a rising public health problem with increasing global age prevalence. Exacerbation of COPD in the elderly has a significant negative impact on the clinical and paraclinical picture, daily activity capacity, and quality of life. The need for correct diagnostic management is dictated by the severity of the pathology in the elderly and the high frequency of cardiac complications. Studying the clinical-paraclinical picture and the diagnostic capacity of natriuretic peptides in COPD patients with cardiovascular complications was the aim of the present research. Material and methods. We conducted an analytical, observational, case-control study with the use of modern research methods. The study included 194 elderly patients (≥ 65 years old) divided into two study groups: those with only COPD (COPD group) and those with associated pulmonary hypertension (PHCOPD group). Patients underwent clinical, paraclinical, and functional investigation methods with subsequent mathematical-statistical data processing. Results. The study groups were similar according to socio-demographic data. The clinical assessment revealed that PHCOPD patients had, in comparison with COPD patients, statistically significantly more frequent and severe complaints. The objective examination determined that in PHCOPD patients, the values of the objective examination indices were much more affected than in the COPD group. At the complex geriatric assessment, the COPD group of patients shows a lower degree of dependence and less cognitive impairment. The multidimensional assessment of COPD reflected more severe impairment according to the CAT, SGRQ, CCQ, mMRC, BODE questionnaires, and 6MWT test in the PHCOPD group compared to the COPD group. Spirographic, radiographic, ultrasonographic, and echocardiographic evaluations correlated with age, inflammatory syndrome, and natriuretic peptide level. Conclusions. The PHCOPD group patients present a clinical picture, exercise capacity, objective data, complex geriatric assessment scores, and a multidimensional assessment of COPD that is statistically more frequent and severely affected compared to the COPD group. The impact of hemodynamic disturbances in COPD could be confirmed by the correlation of paraclinical data, such as the inflammatory response syndrome, increased natriuretic peptides, echocardiography data, and indices of internal organ ultrasound examination.

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Section: Introductionmentioning

confidence: 99%