Current biomarkers for the detection of endometriosis

Tian, Zhong; Chang, Xiaohong; Zhao, Yan; Zhu, Huaqun

doi:10.1097/cm9.0000000000001063

Cited by 27 publications

(26 citation statements)

References 59 publications

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“…A meta-analysis published found that the patients with endometriosis have higher levels of CA-125, particularly in the most severe stages. 23 In this study, serum CA-125 level was increased in the serum of DES group. Also, pathological identification revealed degenerated glandular cells, epithelium in the endo group confirms the endometriosis induction.…”

Section: L-70supporting

confidence: 47%

Evidence Supporting the Diethylstilbestrol Induction of Endometriosis Via Immune-Inflammatory Pathway in Rat Model

Krishnamoorthy

Kadalmani

2022

Int J Life Sci Pharm Res

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Endometriosis is a benign reproductive disorder distinguished by chronic inflammation and anomalous progress of stromal cells and glands outside the uterus. Though the etiology of endometriosis is still a matter of debate, the immuneinflammatory mediators are thought to play a major role. Macrophage infiltration and proinflammatory intermediaries in the peritoneal environment peritoneal milieu impact ovarian, uterine function and pelvic morphology, resulting in endometriosis symptoms and signs. The endometriosis model system was developed using diethylstilbestrol (DES) which is examined to develop the disease via the immune-inflammatory pathway. The immune-inflammatory markers (NFKB, MAPK, TNF-α, IL-6 and STAT- 3) were investigated in this study. The results demonstrated that the DES induced endometriosis animal model had a higher level of CA-125, a biomarker of endometriosis. Endometriosis-induced groups had increased levels of NFKB, MAPK, TNF-α, IL-6 and STAT-3 which clearly depicts the immune-inflammatory role in the induction. Finally, the results conclude that DES induced endometriosis via the immune-inflammatory pathway.

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Section: L-70supporting

confidence: 47%

Evidence Supporting the Diethylstilbestrol Induction of Endometriosis Via Immune-Inflammatory Pathway in Rat Model

Krishnamoorthy

Kadalmani

2022

Int J Life Sci Pharm Res

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“…It has been scientifically proven that there is a correlation between high CA-125 and the stage of the disease and its clinical type [18]. The sensitivity of endometriosis stage III and IV was 63.1%, compared to only 24.8% in stage I and II.…”

Section: Glycoproteinsmentioning

confidence: 99%

Novel Diagnostic Markers for Endometriosis

Kimber-Trojnar¹,

Pilszyk²,

Niebrzydowska³

et al. 2021

Preprint

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Endometriosis is a disease that affects women of reproductive age and has a significant impact on their well-being. The main symptoms are dysmenorrhea, chronic pelvic pain and infertility. The diagnostic process in many cases is very long and can take up to 8-12 years. Laparoscopy, which is an invasive method, is still necessary to confirm final identification. Therefore, the development of diagnostic markers seems to be crucial for the diagnosis and proper treatment of women affected by endometriosis as soon as possible. Still the most frequently studied and used marker is Cancer Antigen 125 (CA-125). Other glycoproteins, growth factors and immune markers seem to play an important role. However, the search for the ideal endometriosis marker is still ongoing. Developing researches on endometriosis pathogenesis help to identify potential biomarkers or sets of biomarkers in order to improve and speed up the diagnostic process in a non-invasive way.

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“…The identification of diagnostic biomarkers is thus urgently required to improve the diagnosis and treatment of patients with endometriosis. Previous reviews on this topic have focused on identification of potential biomarker candidates from specimens such as peritoneal fluid, blood, urine, and endometrial biopsies (6)(7)(8)(9), highlighting several factors as noninvasive diagnostic biomarkers, including growth factors, hormones, cytokines, complements, glycoproteins, and antibodies. However, these biomarkers are merely used to supplement diagnosis of endometriosis, as none of them has demonstrated sufficient sensitivity and specificity (10).…”

Section: Introductionmentioning

confidence: 99%

Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics

Bae

Cho

et al. 2022

Front. Endocrinol.

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Endometriosis is a gynecological disease prevalent in women of reproductive age, and it is characterized by the ectopic presence and growth of the eutopic endometrium. The pathophysiology and diagnostic biomarkers of endometriosis have not yet been comprehensively determined. To discover molecular markers and pathways underlying the pathogenesis of endometriosis, we identified differentially expressed genes (DEGs) in three Gene Expression Omnibus microarray datasets (GSE11691, GSE23339, and GSE7305) and performed gene set enrichment analysis (GSEA) and protein–protein interaction (PPI) network analyses. We also validated the identified genes via immunohistochemical analysis of tissues obtained from patients with endometriosis or healthy volunteers. A total of 118 DEGs (79 upregulated and 39 downregulated) were detected in each dataset with a lower (fold change) FC cutoff (log2|FC| > 1), and 17 DEGs (11 upregulated and six downregulated) with a higher FC cutoff (log2|FC| > 2). KEGG and GO functional analyses revealed enrichment of signaling pathways associated with inflammation, complement activation, cell adhesion, and extracellular matrix in endometriotic tissues. Upregulation of seven genes (C7, CFH, FZD7, LY96, PDLIM3, PTGIS, and WISP2) out of 17 was validated via comparison with external gene sets, and protein expression of four genes (LY96, PDLIM3, PTGIS, and WISP2) was further analyzed by immunohistochemistry and western blot analysis. Based on these results, we suggest that TLR4/NF-κB and Wnt/frizzled signaling pathways, as well as estrogen receptors, regulate the progression of endometriosis. These pathways may be therapeutic and diagnostic targets for endometriosis.

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Current biomarkers for the detection of endometriosis

Cited by 27 publications

References 59 publications

Evidence Supporting the Diethylstilbestrol Induction of Endometriosis Via Immune-Inflammatory Pathway in Rat Model

Evidence Supporting the Diethylstilbestrol Induction of Endometriosis Via Immune-Inflammatory Pathway in Rat Model

Novel Diagnostic Markers for Endometriosis

Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics

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