Current challenges and advancements towards discovery and resistance of antibiotics

Verma, Tarun; Khare, Deepa; Singh, Samiksha; Sharma, Sumit; Sarma, Saurabh Jyoti

doi:10.1016/j.molstruc.2021.131380

Cited by 46 publications

(12 citation statements)

References 86 publications

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“…Antibiotics are necessary medicines; many of them are on the WHO list of essential medicines, and their consumption is continuously increasing [ 1 , 2 ]. Unfortunately, some of these substances are excreted from the body unmetabolized in percentages that vary depending on the compound (up to 80% for tetracycline [ 3 ]), and their accumulation in wastewater and soil causes complications [ 4 , 5 , 6 , 7 , 8 ]. The presence of antibiotics in wastewater and also in drinking water has been detected in small amounts, but this is quite alarming for environmental safety [ 2 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of antibiotics in wastewater and also in drinking water has been detected in small amounts, but this is quite alarming for environmental safety [ 2 , 9 ]. The use of antibiotics in excess also leads to the appearance of antibiotic-resistant microorganisms [ 5 , 6 , 10 , 11 ]. Antibiotic resistance is a current problem leading to a decrease in the effectiveness of these classes of drugs.…”

Section: Introductionmentioning

confidence: 99%

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Photocatalytic Removal of Antibiotics from Wastewater Using the CeO2/ZnO Heterojunction

et al. 2023

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CeO2/ZnO-based photocatalytic materials were synthesized by the sol-gel method in order to establish heterojunctions that increase the degradation efficiency of some types of antibiotics by preventing the recombination of electron–hole pairs. The synthesized materials were analysed by XRD, SEM, EDAX, FTIR, and UV-Vis. After several tests, the optimal concentration of the catalyst was determined to be 0.05 g‧L−1 and 0.025 g‧L−1 for chlortetracycline and 0.05 g‧L−1 for ceftriaxone. CeO2/ZnO assemblies showed much better degradation efficiency compared to ZnO or CeO2 tested individually. Sample S3 shows good photocatalytic properties for the elimination of ceftriaxone and tetracycline both from single solutions and from the binary solution. This work provides a different perspective to identify other powerful and inexpensive photocatalysts for wastewater treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photocatalytic Removal of Antibiotics from Wastewater Using the CeO2/ZnO Heterojunction

et al. 2023

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“…Once referred to as one of the last antibiotic groups, resistance to it has now spread to many countries across at least four continents ( 8 , 9 ). With the time to launch a new antibiotic estimated at around 15 years ( 10 ), antibiotic resistance in bacteria is a matter of global concern, and its horizontal transfer in the ecosystem aggravates the risk to public health. Years of research have confirmed that antimicrobial peptides can be suitable as alternative antibacterial drugs ( 11 , 12 ) and have the potential to be used against antibiotic-resistant bacteria ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Discovery and Mechanism of Action of a Novel Antimicrobial Peptide from an Earthworm

Deng

Wang

et al. 2023

Microbiol Spectr

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“…Global production of cephalosporin antibiotics was USD 13.69 billion in 2019 and will reach USD 16.87 billion by 2027 [ 6 ]. The most common uses of cephalosporins are aquaculture and human and veterinary medicine [ 7 , 8 , 9 , 10 , 11 ]. Incorrect use of cephalosporin antibiotics for the treatment of disease or growth promotion in livestock results in significant drug residues in dairy products.…”

Section: Introductionmentioning

confidence: 99%

Analytical Determination of Cephalosporin Antibiotics Using Coordination Polymer Based on Cobalt Terephthalate as a Sorbent

et al. 2023

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In this work, a coordination polymer based on cobalt terephthalate was obtained and characterized by elemental analysis, infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy. The coordination polymer was tested as a sorbent for the solid-phase extraction of cephalosporin antibiotics, including ceftriaxone, cefotaxime, and cefazolin, from aqueous solutions. The coordination polymer had a high adsorption capacity (520.0 mg/g). Antibiotics adsorption followed pseudo-second order kinetic model and the Freundlich isotherm model. The calculated thermodynamic parameters indicate a spontaneous process. The resulting coordination polymer has good stability and reusability. The possibility of separating the studied cephalosporins on a chromatographic column filled with a coordination polymer was shown. This work opens great prospects for the development and application of a coordination polymer based on cobalt terephthalate for the removal of cephalosporins from ambient water.

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Current challenges and advancements towards discovery and resistance of antibiotics

Cited by 46 publications

References 86 publications

Photocatalytic Removal of Antibiotics from Wastewater Using the CeO2/ZnO Heterojunction

Photocatalytic Removal of Antibiotics from Wastewater Using the CeO2/ZnO Heterojunction

Discovery and Mechanism of Action of a Novel Antimicrobial Peptide from an Earthworm

Analytical Determination of Cephalosporin Antibiotics Using Coordination Polymer Based on Cobalt Terephthalate as a Sorbent

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