Current concepts in the pathogenesis of Crohn's disease

GIBSON, PETER R.

doi:10.1111/j.1440-1746.1990.tb01767.x

Cited by 10 publications

(6 citation statements)

References 145 publications

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“…The etiology of CD remains unknown (6)(7)(8)(9). However, there is a consensus that cytokines play pivotal (10)(11)(12)(13), if on occasions apparently conflicting (12,(14)(15)(16), roles in the clinical manifestations of CD.…”

mentioning

confidence: 99%

Molecular evidence for two forms of Crohn disease.

Gilberts¹,

Greenstein²,

Katsel³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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Recent epidemiological evidence suggests that there are two forms of Crohn disease (CD): perforating and nonperforating. We hypothesized that, just as with tuberculoid and lepromatous leprosy, differences in the two forms of CD would be both identified and determined by differences in the host immune response. Resected intestinal tissue from control patients as well as perforating and nonperforating CD patients was evaluated for mRNA levels. We employed 32p PCR amplification with published or custom-designed primers of a housekeeping gene (13-actin); a human T-cell marker (CD3-6); and the cytokines tumor necrosis factor a, transforming growth factor (3, granulocyte/macrophage colony-stimulating factor, interleukin (IL) 1(3, IL-lra, and IL-6. Differences were identified with IL-1,B (control = 162 ± 57 vs. perforating = 464 ± 154 vs. nonperforating = 12,582 ± 4733; P c 0.02) and IL-lra (control = 1337 ± 622 vs. perforating = 2194 ± 775 vs. nonperforating = 9715 ± 2988; P < 0.02). These data corroborate the epidemiological observation that there are two forms of CD. Nonperforating CD, the more benign form, is associated with increased IL-1,B and IL-lra mRNA expression. We conclude that it is the host immune response that determines which form of CD becomes manifest in any given individual and discuss the investigative, diagnostic, and therapeutic implications of these observations.

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mentioning

confidence: 99%

Molecular evidence for two forms of Crohn disease.

Gilberts¹,

Greenstein²,

Katsel³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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“…Intestinal vasculitis has also been implicated (3). Proposed infectious causes include persistent measles virus (4) and mycobacteria, particularly Mycobacterium paratuberculosis (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

On the etiology of Crohn disease.

Mishina¹,

Katsel²,

Brown³

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

165

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“…Previous research has proposed that CD is not a particular disease entity because of its varied nature; rather a range of related idiopathic conditions co-occur [ 51 , 52 ] . Although this issue is highly controversial, some believe that bacterial infections such as MAP are one of the key players in the induction of idiopathic CD.…”

Section: Introductionmentioning

confidence: 99%

Potential Vaccines for Treating Crohn's Disease

Rostami-Nejad

Yazdi

Nikfar

et al. 2020

ibj

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CD is an inflammatory disease of the GIT and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of IBD patients and the role of bacteria such as MAP in CD. Apart from different therapeutic approaches for treating CD, development of a vaccine is a novel modality. In the present article, most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed. According to the search, availability of a new generation of vaccines against CD is expected specially tolerogenic ex vivo-derived DC-based vaccines. Regarding different locations of the challenge and the variety of clinical manifests of CD and also the type of resident antigen-presenting cells and their traffic in different parts of GIT, the results of immunotherapy with DC-based vaccines may vary case by case.

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Current concepts in the pathogenesis of Crohn's disease

Cited by 10 publications

References 145 publications

Molecular evidence for two forms of Crohn disease.

Molecular evidence for two forms of Crohn disease.

On the etiology of Crohn disease.

Potential Vaccines for Treating Crohn's Disease

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