Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide

Özgöçmen, Salih; Özyurt, Hüseyın; Söğüt, Sadık; Akyol, Ömer

doi:10.1007/s00296-005-0078-z

Cited by 105 publications

(70 citation statements)

References 118 publications

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“…The polyphenols in OPC have shown beneficial antioxidant effects on oxidative-stress-associated diseases. It has been suggested that oxidative stress plays an important role in the pathobiology of FM [1,7,24,25].…”

Section: Resultsmentioning

confidence: 99%

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Analgesic Effect of Grape Seed Proanthocyanidin Extract in Fibromyalgia Animal Model

Mun¹,

Seong-Ho²,

Jang³

et al. 2010

Journal of Life Science

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The acidic saline animal model of pain has been suggested to mimic fibromyalgia (FM). Oligomeric proanthocyanidin complexes (OPC) from grape seeds are known to act as an antioxidant. We studied the effects of OPC on the pain threshold in the acidic saline animal model of pain. The left gastrocnemius muscle was injected with 100 μl of saline at pH 4.0 under brief isoflurane anesthesia on days 0 and 5. Control rats (n=5) received identical injections of physiological saline (pH 7.2) on the same schedule. Rats (n=10) with acidic saline injection were separated into two study subgroups. After measurement of pre-drug pain thresholds, rats were injected intraperitoneally with either saline or OPC 300 mg/kg. Paw withdrawal thresholds to pressure were again measured 60 min after intraperitoneal injection. Nociceptive thresholds were measured with a Dynamic Plantar Aesthesiometer by applying an increasing pressure to right or left hind paw until the rat withdrew the paw. Compared to baseline (day 0), acid injections produced mechanical hyper-responsiveness on day 7 (pre-drug) in these rats [p<0.05]. A potent antihyperalgesic effect was observed when rats were injected intraperitoneally with OPC 300 mg/kg [injected paw, p=0.001; contralateral paw, p=0.002]. OPC treatment decreased the expression of acid sensing ion channel 3 in the brain motor cortex area on immunohistochemical staining when OPC 300 mg/kg was administered intraperitoneally in the animal model of FM pain [p<0.05]. Further research is required to determine the efficacy of OPC treatments in FM pain in humans.

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Section: Resultsmentioning

confidence: 99%

“…Abnormal sensitization and temporal summation of second pain (windup) have been described in patients with FM [35]. Oxidative stress and nitric oxide may play an important role in FM pathophysiology, however it is still not clear whether oxidative stress abnormalities documented in FM are the cause or the effect [1,7,24,25].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effect of Grape Seed Proanthocyanidin Extract in Fibromyalgia Animal Model

Mun¹,

Seong-Ho²,

Jang³

et al. 2010

Journal of Life Science

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“…These agents seem to act as initiators of an oxidation reactions cycle which is not totally counteracted by the antioxidant defences. This may be a potential cause of the development of FM and also of chronic fatigue syndrome (CFS) [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Fibromyalgia and nutrition, what do we know?

Arranz

Canela²,

Rafecas

2010

Rheumatol Int

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Objective: Many people suffer from fibromyalgia (FM) without an effective treatment. They do not have a good quality of life and cannot maintain normal daily activity. Among the different hypotheses for its ethiopathophysiology, oxidative stress is one of the possibilities. Non-scientific information addressed to patients regarding the benefits of nutrition is widely available, and they are used to trying non-evidenced strategies. The aim of this paper is to find out what we know right now from scientific studies regarding fibromyalgia disease and nutritional status, diets and food supplements. Design: A systematic search has been performed on Medline with a wide range of terms about these nutritional issues. Setting: the search has been made during 2009, for articles published between 1998 and 2008. Subjects: people suffering from FM. Results: Vegetarian diets could have some beneficial effects probably due to the increase in antioxidant intake. There is a high prevalence of obesity and overweight in patients, and weight control seems to be an effective tool to improve the symptoms. Some nutritional deficiencies have been described, it is not clear whether they are directly related to this disease or not. About the usefulness of some food supplements we found very little data, and it seems that more studies are needed to prove which ones could be of help. Conclusions: Dietary advice is necessary to these patients to improve their diets and maintain normal weight. It would be interesting to investigate more in the field of nutrition and FM to reveal any possible relationships.

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“…Transaldolase is an enzyme of the non-oxidative phase of the pentose phosphate pathway, which is involved in the generation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). There is a lot of evidence have shown that oxidative stress and nitric oxide may play an important role in fibromyalgia pathophysiology (Ozgocmen et al, 2006).…”

Section: Wwwintechopencommentioning

confidence: 99%