Current concepts of Kimura disease: pathophysiology and evolution of treatment

Abstract

Kimura disease (KD) is a chronic inflammatory disorder that frequently involves the subcutaneous tissue of the head and neck regions. It often manifests as regional lymphadenopathy or salivary gland enlargement in the affected area. The histologic architecture of the lymph nodes in KD patients is preserved, while the affected tissues show follicular hyperplasia and eosinophilic infiltration. No single modality has been adopted as an optimal treatment for KD. This article concentrates on the fundamental features of KD and reviews current approaches to its treatment.

Bilateral swelling of the salivary glands and sicca symptoms: an unusual differential diagnosis—Kimura’s disease, a rare allergic condition with a high IgE serum level—a case report and review of the literature

“…The differential diagnosis of Kimura‘s disease also includes angiolymphoid hyperplasia with eosinophilia, angioimmunoblastic T-cell lymphoma, Hodgkin lymphoma, Langerhans cell histiocytosis, Castleman disease, florid follicular hyperplasia, dermatopathic lymph-adenopathy, drug reaction, tumour node metastases and parasitic lymphadenitis. 27 …”

Isolated Fibrous Dysplasia of the Bilateral Nasal Bones: Complex Management of the Bony Vault

“…It often presents before skeletal maturity, arising around 10 years of age. 3 Craniofacial FD has been found to develop particularly early, often citing lesion formation before the age of three. 3 Additionally, craniofacial FD differs from axial-based disease, in that lesions are slower growing.…”

“…3 Craniofacial FD has been found to develop particularly early, often citing lesion formation before the age of three. 3 Additionally, craniofacial FD differs from axial-based disease, in that lesions are slower growing. This often results in gradual, painless swelling and progressive asymmetry.…”

“…FD can be categorized into monostotic and polyostotic disease, affecting a single or several sites, respectively. Craniofacial involvement is frequently noted in polyostotic disease (50%–90%), 3 whereas it is less commonly observed in monostotic cases. Of the 10%–25% of monostotic cases affecting the craniofacial skeleton, most involve the maxilla, mandible, and bones of the cranium.…”

“…This often results in gradual, painless swelling and progressive asymmetry. 3 Other symptoms may include headache, facial pain, and auditory or visual impairment due to neurovascular impingement. 1…”