Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Rocca, Ylenia Della; Traini, Enrico Matteo; Diomede, Francesca; Fonticoli, Luigia; Trubiani, Oriana; Paganelli, Alessia; Pizzicannella, Jacopo; Marconi, Guya Diletta

doi:10.3390/pharmaceutics15030908

Cited by 14 publications

(5 citation statements)

References 127 publications

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“…However, they are more prominent in bone marrow [71]. Recently, MSCs have been discovered to represent potential target cells for BPA [72,73]. The proadipogenic effect of BPA is widely reported.…”

Section: Bpa and Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases

Maduabuchi Aja,

Victor Fasogbon,

Adomi Mbina

et al. 2024

Bisphenols - New Environmental, Pathophysiological and Social Perspectives [Working Title]

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Bisphenol-A (BPA) is a widely used chemical compound in the production of consumer items and building materials. Over the years, concerns have been raised about its potential adverse effects on human health. This chapter aims to explore the existing evidence regarding the association between BPA exposure and the risk of non-communicable diseases (NCDs). NCDs, such as cardiovascular diseases, diabetes, obesity, and certain types of cancer, are the leading causes of morbidity and mortality worldwide. Multiple studies have investigated the potential role of BPA in the development and progression of these diseases. Epidemiological studies have also provided evidence suggesting a link between BPA exposure and NCDs in humans. Several potential mechanisms have been proposed to explain the effects of BPA on NCDs, including its ability to mimic estrogenic activity and alter hormone signaling. A broader knowledge of the association between BPA and NCDs can inform public health policies and strategies aimed at reducing BPA exposure towards mitigating the burden of NCDs. In general, while the evidence regarding the association between BPA exposure and NCDs is still evolving, the existing literature suggests a potential link between BPA exposure and an increased risk of developing various non-communicable diseases.

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Section: Bpa and Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases

Maduabuchi Aja,

Victor Fasogbon,

Adomi Mbina

et al. 2024

Bisphenols - New Environmental, Pathophysiological and Social Perspectives [Working Title]

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“…BPA can be found in some personal care products, such as sunscreen and lotions, as well as in certain types of thermal paper, such as receipts. Although the amount of BPA that can be absorbed through the skin is low, it can still contribute to overall exposure [41,42].…”

Section: Exposure Biotransformation and Toxic Effects In Humansmentioning

confidence: 99%

“…BPA exposure has also been linked to metabolic disorders, such as obesity and type 2 diabetes. One theory is that BPA may interfere with the body's insulin signaling pathways, leading to insulin resistance and impaired glucose metabolism [42][43][44].…”

Section: Exposure Biotransformation and Toxic Effects In Humansmentioning

confidence: 99%

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Role of Fungi in Biodegradation of Bisphenol A: A Review

Kristanti,

Ningsih,

Yati

et al. 2023

Trop. Aqua. Soil Pollut.

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Bisphenol A (BPA) is recognized as an endocrine disruptor, capable of interfering with the normal functioning of hormones within the body by mimicking the effects of estrogen. Drinking water is one of the most common pathways of exposure to BPA as it can permeate plastic products and other materials, entering water sources. This article presents a comprehensive overview of BPA, including its incidence, origins, environmental fate, its impact on human health, and the role of fungi in the biodegradation of BPA. Fungi are natural decomposers, capable of breaking down organic compounds, including BPA, under suitable conditions. Studies have demonstrated that specific species of fungi can effectively biodegrade BPA. Some fungi utilize ligninolytic enzymes, such as laccases and peroxidases, to break down the phenolic rings of BPA. Other fungi employ non-ligninolytic enzymes, such as esterases and hydrolases, to cleave the ester linkages in BPA. Furthermore, some fungi can break down BPA via cometabolic pathways, whereby the chemical is degraded as a side reaction to the degradation of another substrate. The use of immobilized enzymes for BPA degradation has also demonstrated potential. Immobilized enzymes are those that are attached to a solid support, such as a polymer or matrix, allowing them to be used multiple times and enhance their stability and catalytic activity

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“…BPA interacts with several biological receptors such as estrogen receptor (ER), androgen receptor (AR), and thyroid hormone receptor (THR), resulting in endocrine-disrupting effects. These effects lead to adverse outcomes such as reproductive and developmental issues in the offspring, reproductive dysfunction, neurotoxicity, mutagenesis, and even cancer development [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation

Lee,

Park,

Park

2023

Toxics

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Bisphenol A (BPA) exposure has been widely linked to endocrine-disrupting effects. Recently, many substitutes for BPA have been developed as safe structural analogs. However, they have still been reported to have similar adverse effects. The current study evaluated the effects of bisphenol A and eight structural analogs on the transcription of estrogen receptor alpha (ERα). The effects of binary and ternary mixtures prepared from different combinations of BPA analogs were also evaluated for transcription activity. The measured data of the mixtures were compared to the predicted data obtained by the full logistic model, and the model deviation ratio (MDR) was calculated to determine whether the effects were synergistic, antagonistic, or additive. Overall, the results suggest that the effect of bisphenol compound are additive in binary and ternary mixtures.

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Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Cited by 14 publications

References 127 publications

Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases

Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases

Role of Fungi in Biodegradation of Bisphenol A: A Review

Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation

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