Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis

Abstract

In this article, inconsistency of the association of polymorphisms of fibroblast growth factor receptor 2 (FGFR2) with breast cancer is noted. Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies. The results showed that all these three polymorphisms were significantly associated with altered breast cancer risk in any model (co-dominant, dominant, or recessive model) and in stratification based on ethnicity and study design. In the subgroup analyses for postmenopausal women, significantly increased risks were found for rs1219648 and rs2420946 in any model. This meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of breast cancer. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.

Association of Genome-Wide Association Study (GWAS) Identified SNPs and Risk of Breast Cancer in an Indian Population

“…Our current data support the conclusions of previous GWAS studies1819 that FGFR2 (a tumour suppressor gene) polymorphisms (rs2981582 and rs2981575), first identified as susceptibility loci for BC in Caucasian population2021, are associated with overall BC. The risk allele frequencies of FGFR2 SNPs were similar to those reported in previous GWAS, with the exception of rs2981575, which was much common in our population.…”

Relation of Alcohol/Tobacco use with Metastasis, Hormonal (Estrogen and Progesterone) Receptor Status and c-erbB2 Protein in Mammary Ductal Carcinoma

“…More recent systematic reviews with meta-analysis (Zhang et al, 2010b) and individual studies (Zhang et al, 2010a) suggest that in the long run a history of smoking in women with a polymorphism of the N-acetyltransferase 2 gene can contribute to susceptibility to cancer. On the other hand, in our university there was an unpublished study by Marian et al (2011) with solid evidence showing that in Mexican women the polymorphism of the FGFR2 gene mediates the increased risk of cancer produced by alcohol use.…”

An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast cancer

“…Recently, the FGFR2 gene, one of the low-penetrance genes, has been identified as a potential susceptible gene common to breast cancer. [20] The FGFR2 gene product functions as FGF receptors where the FGFR2b and FGFR2c isoforms have different expression domains and ligand specificities. [21] FGFR2 is a member of the FGFR family of receptor tyrosine kinases (RTK).…”