Current health risk assessment practice for dietary cadmium: Data from different countries

Satarug, Soisungwan; Vesey, David A.; Gobé, Glenda C.

doi:10.1016/j.fct.2017.06.013

Cited by 167 publications

(144 citation statements)

References 138 publications

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“…It has been well established that cadmium (Cd) is a toxic environmental pollutant . Diet and smoking are the two major methods by which Cd is taken up by the human body, and long‐term exposure causes chronic Cd toxicity . Cd exhibits toxic effects on various organs and cells in the body .…”

Section: Introductionmentioning

confidence: 99%

Effect of cadmium on osteoclast differentiation during bone injury in female mice

Zhuo

Liu

et al. 2019

Environmental Toxicology

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Cadmium (Cd) is a toxic heavy metal that represents an occupational hazard and environmental pollutant toxic heavy metal, which can cause osteoporosis following accumulation in the body. The purpose of this study was to investigate the effect of Cd on bone tissue osteoclast differentiation in vivo. Female BALB/c mice were randomly divided into three groups and given drinking water with various concentrations of Cd (0, 5, and 25 mg/L) for 16 weeks, after which the mice were sacrificed after collecting urine and blood. The level of Cd, calcium (Ca), phosphorus (P), trace elements, and some biochemical indicators were measured, and the bone was fixed in a 4% formaldehyde solution for histological observation. Bone marrow cells were isolated to determine the expression of osteoclast‐associated mRNA and proteins. Cd was increased in the blood, urine, and bone in response to Cd in drinking water in a dose‐dependent manner. The content of iron (Fe), manganese (Mn), and zinc (Zn) was significantly increased, whereas Ca and P were decreased in bone compared to the control group. Cd affected the histological structure of the bone, and induced the upregulation and downregulation of tartrate‐resistant acid phosphatase 5b (TRACP‐5b) and estradiol in the serum, respectively. Cd had no significant effect on the alkaline phosphatase activity in the serum. The expression of osteoclast marker proteins, including TRACP, cathepsin K, matrix metalloprotein 9, and carbonic anhydrases were all increased in the Cd‐treated bone marrow cells. Cd significantly increased the expression of receptor activator of nuclear factor kappa B ligand (RANKL), but had lower effect on the expression of osteoprotegerin (OPG) in both bone marrow cells and bone tissue. Thus, Cd exposure destroyed the bone microstructure, promoted the formation of osteoclasts in the bone tissue, and accelerated bone resorption, in which the OPG/RANKL pathway may play an important role.

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Section: Introductionmentioning

confidence: 99%

Effect of cadmium on osteoclast differentiation during bone injury in female mice

Zhuo

Liu

et al. 2019

Environmental Toxicology

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“…As food is the main source of Cd in the non‐smoking section of the general population (EFSA, ; Satarug et al, ), special attention should be paid to the quality of consumed food. It is particularly important concerning functional food and dietary supplements.…”

Section: Polyphenol‐rich Products In Protection and Treatment Of Cd‐imentioning

confidence: 99%

“…Because environmental and occupational exposure to Cd is still a serious health problem (Fagerberg et al, ; Hyder et al, ; Lin et al, ; Satarug et al, , ; Wallin et al, ; Wang et al, ), particularly in industrialized and developing countries, it is of great importance to find an effective strategy to protect against the unfavorable effects of exposure to Cd and treatment of them. Among the potential protective and therapeutic factors, particularly promising not only in the prevention but also in the treatment of health outcomes of this metal intoxication in humans seem to be polyphenol‐rich dietary products.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

“…These data, together with reports on the unavoidable and increasing lifetime exposure of the general population in industrialized countries to numerous substances hazardous to health (United Nations Environment Programme [UNEP], 2010; World Health Organization [WHO], 2010a), have attracted growing attention that has now been focused not only on recognizing the main environmental risk factors for human health, but also on effective ways of preventing the unfavorable effects of exposure to them, or at least to ameliorating these effects (Mężyńska & Brzóska, 2018;Nogawa et al, 2017;WHO, 2010aWHO, , 2010b. It is particularly important in regard to organs and systems at highest risk of damage, such as the liver (Hyder et al, 2013;Kang, Cho, Lim, Seo, & Hong, 2013;Mężyńska & Brzóska, 2018;Satarug et al, 2017aSatarug et al, , 2017bWallin et al, 2016;Wang et al, 2016) .…”

Section: Introductionmentioning

confidence: 99%

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Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Mężyńska

Brzóska

2018

J of Applied Toxicology

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Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.

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“…Cd can enter human body through consumption of crops and vegetables, which accumulated Cd from contaminated soils. Nephrotoxicity is the most frequently reported toxicity after chronic dietary Cd exposure, as the kidney is the main storage organ of accumulated Cd (Satarug, ; Satarug, Vesey, & Gobe, ). Bone is another major target organ of Cd due to chronic dietary exposure (Chen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Yan

et al. 2019

J of Applied Toxicology

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Both cadmium (Cd) and lead (Pb) are associated with bone health, but studies exploring the effects of Cd and Pb co‐exposure on bone health are rare. This study aimed to assess the interactive effects of Cd and Pb co‐exposure on bone health. In total, 799 participants, living in the targeted areas (located in southwestern China) for more than 15 years, aged 40‐75 years, and subsisted on homegrown rice and vegetables were investigated. Cd and Pb levels in urine and blood samples, as well as bone mineral density, T‐ and Z‐score were determined. After being adjusted for covariates, the T‐score was negatively correlated with blood Pb in men (P < .05); for women and non‐smoking women, the T‐score was negatively correlated with urinary Pb (P < .05). Moreover, after being adjusted for covariates, the Z‐score was negatively correlated with urinary Pb in non‐smoking women (P < .05). No positive association of prevalence of osteoporosis with Cd and Pb exposure was found. However, at an additive scale, positive interactions of urinary Cd and Pb on the prevalence of osteoporosis for women and non‐smoking women, and the same interactions to blood Cd and Pb for men were found. There was also a positive interaction of urinary Cd and Pb for women at a multiplicative scale. This study suggests Cd and Pb exposure could exert detrimental effects on bone health, with possible underlying interactions. Nevertheless, more studies are needed to explore the interactive effects of heavy metal co‐exposure.

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Current health risk assessment practice for dietary cadmium: Data from different countries

Cited by 167 publications

References 138 publications

Effect of cadmium on osteoclast differentiation during bone injury in female mice

Effect of cadmium on osteoclast differentiation during bone injury in female mice

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

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