Current Immunotherapy Approaches for Malignant Melanoma

Lim, Jaesung; Cho, Eunjin; Lee, Kyung-Woo; Choi, Yonghyun; Seo, Youngmin; Jeon, Hojeong; Choi, Jonghoon

doi:10.1007/s13206-019-3108-8

Cited by 14 publications

(11 citation statements)

References 68 publications

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“…In general, commercial formulations of sunscreens are comprised of mainly geometrical (E)-isomers (trans-), but many of them contain a mixture of both isomers (E) and (Z)-isomers (cis-) (for example methoxycinnamate). Because of their high lipophilic character (log K ow [4][5][6][7][8] and relative stability against biological decomposition, they were found to also accumulate in the food chain (detection of some UV filters in fish was in the range of 25-1800 ng/g, and in the fat of human milk was in the range of 16-417 ng/g) [6].…”

Section: Group Typical Representativesmentioning

confidence: 99%

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Stability and Removal of Benzophenone-Type UV Filters from Water Matrices by Advanced Oxidation Processes

et al. 2022

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Benzophenone (BP) type UV filters are common environmental contaminants that are posing a growing health concern due to their increasing presence in water. Different studies have evidenced the presence of benzophenones (BP, BP-1, BP-2, BP-3, BP-4, BP-9, HPB) in several environmental matrices, indicating that conventional technologies of water treatment are not able to remove them. It has also been reported that these compounds could be associated with endocrine-disrupting activities, genotoxicity, and reproductive toxicity. This review focuses on the degradation kinetics and mechanisms of benzophenone-type UV filters and their degradation products (DPs) under UV and solar irradiation and in UV-based advanced oxidation processes (AOPs) such as UV/H2O2, UV/persulfate, and the Fenton process. The effects of various operating parameters, such as UV irradiation including initial concentrations of H2O2, persulfate, and Fe2+, on the degradation of tested benzophenones from aqueous matrices, and conditions that allow higher degradation rates to be achieved are presented. Application of nanoparticles such as TiO2, PbO/TiO2, and Sb2O3/TiO2 for the photocatalytic degradation of benzophenone-type UV filters was included in this review.

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Section: Group Typical Representativesmentioning

confidence: 99%

“…[ 1 ]. These processes are particularly harmful, however, in biological systems, where they cause damage to skin cells, resulting in accelerated ageing of the skin and the emergence of various diseases, from inflammatory processes to cancer [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Stability and Removal of Benzophenone-Type UV Filters from Water Matrices by Advanced Oxidation Processes

et al. 2022

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“…The results of continuous or semi-continuous biosensing in real-time for multiple biomarkers feasibly demonstrate the future of unattended care for patients in hospital or even at home. The real-time monitoring technique is tended to further apply to the new field of liquid biopsy for early diagnosis and prognosis of intractable diseases such as cancers and Alzheimer's 13,44,45 . Microvesicles, cell-free DNA, and target cells are released by different cells and tissues into the body fluid, and can be used to non-invasively screen for incipient-stage disorders and monitor responses to treatment 13 .…”

Section: Simultaneous Biosensing For Dual Ami Biomarkers Ck-mb and Myoglobinmentioning

confidence: 99%

Real-time Monitoring of Biomarkers in Serum for Early Diagnosis of Target Disease

et al. 2020

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Real-time monitoring of biomarkers has important applications in immediately determining, for example, disease progress or therapeutic effects to clinical decisions in the fields of diagnosis, prognosis and therapy. However, technologies developed in this area require frequent sample drawings, unattended analysis in situ, secure online monitoring, and, above all, patient's safety, so from this point of view are still in their infancy. Current research activity in the area has been restricted to the extent of monitoring physical signals while glucose is the only biomarker generally monitored in real-time. To realize the future of unattended analysis, our research group has investigated various immuno-analytical concepts that enable, in particular, repetitive measurements of target biomarkers in a continuous or semi-continuous manner. The key actors in these achievements were monoclonal antibodies with unique characteristics, raised in our group, that potentially allow for real-time monitoring of target disease markers from tiny ionic molecules to complex proteins. Furthermore, we have investigated surrogate elements (e.g. recep-tors and cytokines) that translate cellular response to measurable signals, enabling us to determine the functional properties of analytes. In this review, continuous and semi-continuous monitoring techniques of different markers for acute myocardial infarction are presented.

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“…Sunscreens are primarily designed to protect the skin from the harmful effects of solar ultraviolet radiation (UV irradiation). Chronic excessive and frequent exposure to UV irradiation can cause the occurrence of malignant skin changes [ 1 , 2 , 3 ]. Following the increasing awareness of skin cancer, photoprotection with sunscreens has been widely advocated.…”

Section: Introductionmentioning

confidence: 99%

Analyzing the Photoprotection Efficiency of Sunscreens Containing Antioxidants under Disinfection Conditions

Sotler

Adamič²,

Jarni

et al. 2021

Antioxidants

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Sunscreens ensure thorough protection against sunburn. The delivery of UV filters into the stratum corneum and viable epidermis could be reduced by the use of antioxidants (such as β-carotene and trans-resveratrol, alone or combined). The presence/absence of antioxidants (trans-resveratrol and β-carotene) in formulations containing benzophenone-3 (UV-filter) and their efficiency under disinfection and neutral conditions are studied and compared. The trial was conducted on 38 people. The prepared ointments were applied to the participants’ forearms, irradiated and monitored by reflectance colorimetry after 0, 4, 6, and 8 min. Descriptive statistics were used to describe the skin color’s main characteristics and the F-ratio was used to test overall differences. The ointments containing antioxidants and benzophenone-3 were the most efficient, followed by those with benzophenone-3 alone. It was proven that photoprotection with benzophenone-3 is still effective, despite the formation of its chlorinated products. Due to the short time of exposure to disinfecting conditions, it could be assumed that benzophenone-3 was only partially chlorinated. This clinical study demonstrated that formulations containing antioxidants are likely to be more suitable for protecting skin against UVB irradiation than a UV filter alone.

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Current Immunotherapy Approaches for Malignant Melanoma

Cited by 14 publications

References 68 publications

Stability and Removal of Benzophenone-Type UV Filters from Water Matrices by Advanced Oxidation Processes

Stability and Removal of Benzophenone-Type UV Filters from Water Matrices by Advanced Oxidation Processes

Real-time Monitoring of Biomarkers in Serum for Early Diagnosis of Target Disease

Analyzing the Photoprotection Efficiency of Sunscreens Containing Antioxidants under Disinfection Conditions

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