Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention

Shah, D. C.; Gandhi, Manav; Kumar, Arun; Cruz‐Martins, Natália; Sharma, Rohit; Nair, Sreejayan

doi:10.1080/10408398.2021.1968786

Cited by 41 publications

(27 citation statements)

References 200 publications

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“…miRNAs are found to be dysregulated in several diseases and regulate expression of various genes that are associated with different diseases. We have recently elucidated the non-coding RNA interactome including miRNA networks in cancer chemoprevention (Shah et al, 2021). We have also previously delineated the architecture of miRNA networks in mesothelioma (Gandhi and Nair, 2020), prostate adenocarcinoma (Nair et al, 2014;Nair and Kong, 2015a), cancer chemoprevention (Neelakandan et al, 2012;Nair and Kong, 2015b), as well as miRNA-lncRNA interactions (Nair, 2016).…”

Section: Introductionmentioning

confidence: 99%

New Vistas in microRNA Regulatory Interactome in Neuropathic Pain

Gada¹,

Pandey²,

Jadhav³

et al. 2022

Front. Pharmacol.

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Neuropathic pain is a chronic pain condition seen in patients with diabetic neuropathy, cancer chemotherapy-induced neuropathy, idiopathic neuropathy as well as other diseases affecting the nervous system. Only a small percentage of people with neuropathic pain benefit from current medications. The complexity of the disease, poor identification/lack of diagnostic and prognostic markers limit current strategies for the management of neuropathic pain. Multiple genes and pathways involved in human diseases can be regulated by microRNA (miRNA) which are small non-coding RNA. Several miRNAs are found to be dysregulated in neuropathic pain. These miRNAs regulate expression of various genes associated with neuroinflammation and pain, thus, regulating neuropathic pain. Some of these key players include adenylate cyclase (Ac9), toll-like receptor 8 (Tlr8), suppressor of cytokine signaling 3 (Socs3), signal transducer and activator of transcription 3 (Stat3) and RAS p21 protein activator 1 (Rasa1). With advancements in high-throughput technology and better computational power available for research in present-day pharmacology, biomarker discovery has entered a very exciting phase. We dissect the architecture of miRNA biological networks encompassing both human and rodent microRNAs involved in the development of neuropathic pain. We delineate various microRNAs, and their targets, that may likely serve as potential biomarkers for diagnosis, prognosis, and therapeutic intervention in neuropathic pain. miRNAs mediate their effects in neuropathic pain by signal transduction through IRAK/TRAF6, TLR4/NF-κB, TXIP/NLRP3 inflammasome, MAP Kinase, TGFβ and TLR5 signaling pathways. Taken together, the elucidation of the landscape of signature miRNA regulatory networks in neuropathic pain will facilitate the discovery of novel miRNA/target biomarkers for more effective management of neuropathic pain.

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Section: Introductionmentioning

confidence: 99%

New Vistas in microRNA Regulatory Interactome in Neuropathic Pain

Gada¹,

Pandey²,

Jadhav³

et al. 2022

Front. Pharmacol.

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“…Turmeric is a spice that has garnered attention from both the medical as well as the culinary communities [63][64][65]. Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant and a subset of the Zingiberaceae family [66].…”

Section: Curcuma Longamentioning

confidence: 99%

Plant Bioactives in the Treatment of Inflammation of Skeletal Muscles: A Molecular Perspective

Karati

Varghese

Mahadik

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Skeletal muscle mass responds rapidly to growth stimuli, precipitating hypertrophies (increased protein synthesis) and hyperplasia (activation of the myogenic program). For ages, muscle degeneration has been attributed to changes in the intracellular myofiber pathways. These pathways are tightly regulated by hormones and lymphokines that ultimately pave the way to decreased anabolism and accelerated protein breakdown. Despite the lacunae in our understanding of specific pathways, growing bodies of evidence suggest that the changes in the myogenic/regenerative program are the major contributing factor in the development and progression of muscle wasting. In addition, inflammation plays a key role in the pathophysiology of diseases linked to the failure of skeletal muscles. Chronic inflammation with elevated levels of inflammatory mediators has been observed in a spectrum of diseases, such as inflammatory myopathies and chronic obstructive pulmonary disease (COPD). Although the pathophysiology of these diseases varies greatly, they all demonstrate sarcopenia and dysregulated skeletal muscle physiology as common symptoms. Medicinal plants harbor potential novel chemical moieties for a plenitude of illnesses, and inflammation is no exception. However, despite the vast number of potential antiinflammatory compounds found in plant extracts and isolated components, the research on medicinal plants is highly daunting. This review aims to explore the various phytoconstituents employed in the treatment of inflammatory responses in skeletal muscles, while providing an in-depth molecular insight into the latter.

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“…Among the phytochemicals present, these pine nuts usually contain inherent antioxidants that help in reducing the oxidation rate, namely, flavonoids, e.g., flavonols, and flavanones in various glycoside and aglycone form [ 11 ]. For instance various phenolic group constituents like as catechin, gallic acid and quercetin show antioxidant, antiallergic, antimicrobial, anti-inflammatory, UV protection, and anticancer activity [ 12 , 13 ]. Ellagic acid has potency to inhibit the oxidation of low-density lipoprotein [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Studies of Phytochemicals, Antioxidant, and Antibacterial Activities of Pinus gerardiana and Pinus roxburghii Seed Extracts

Bhardwaj

Sharma

Cruz‐Martins

et al. 2022

BioMed Research International

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Pine seeds are considered as nonwood forest products (NWFP) with regularly increasing market’s demand. They can be eaten in various ways such as roasted or raw. In addition, they are included in various traditional dishes like in cookies, sauces, candies, cakes, breads, and other bakery items and, moreover, for medicinal purposes. GC-MS study is performed to analyze the phytochemical compounds present in the seed extracts of Pinus roxburghii (Chir) and Pinus gerardiana (Chilgoza). In total, 25 compounds were identified each in Chir and Chilgoza. In Chir seeds, abundantly present compounds were 2,4-di-tert-butylphenol (16.6%), followed by ç-Terpinene (9.9%) and cyclohexanol, 4-ethenyl-4-methyl-3-(1-methylethenyl)-, (1à,3à,4á) (9.8%), whereas in Chilgoza seeds, the maximum amount of compound was 1-hexyl-1-nitrocyclohexane (17.3%), followed by phenol, 2,6-bis(1,1-dimethylethyl) (15.4%), and heptadecane, 2-methyl (8.4%). The total phenolic content of Chir seed sample was 1536 ± 4.35 (mg GAE/100 g), whereas in the Chilgoza seed extract was 642.66 ± 2.08 (mg GAE/100 g). The application of RP-HPLC-DAD system revealed that Chir and Chilgoza seeds have maximum quantity of catechin ( 15.77 ± 0.16 μg/mg and 17.49 ± 0.32 μg/mg, respectively). Both Chir and Chilgoza seed extracts exhibited significant antioxidant (radical scavenging) potential, through H2O2 ( 618.94 ± 21.45 μg/mL and 575.16 ± 19.88 μg/mL) and DPPH ( 552.60 ± 13.03 μg/mL and 429.15 ± 3.80 μg/mL) assays, respectively. Additionally, a well-known antibacterial potential was also found in both plants’ dichloromethane extracts, with 64 to 256 μg/mL of minimum inhibitory concentrations. As a whole, result shows the importance of both plants as a naturally occurring phytochemical source with significant antibacterial and antioxidant activity.

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Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention

Cited by 41 publications

References 200 publications

New Vistas in microRNA Regulatory Interactome in Neuropathic Pain

New Vistas in microRNA Regulatory Interactome in Neuropathic Pain

Plant Bioactives in the Treatment of Inflammation of Skeletal Muscles: A Molecular Perspective

Studies of Phytochemicals, Antioxidant, and Antibacterial Activities of Pinus gerardiana and Pinus roxburghii Seed Extracts

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