Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

Prell, Colleen G. Le

doi:10.1007/978-3-319-40848-4_2

Cited by 3 publications

(1 citation statement)

References 106 publications

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“…39 Furthermore, Le Prell and colleagues suggested that examination of both statistical significance and clinical significance provides important information regarding clinical outcomes. 40 When interpreted within the context of listening effort research, this includes consideration of the sensitivity of the VRT task to experimental manipulations (e.g., increasing competing noise level, task instructions) within the context of the measurement error in the task. The overarching goal of this work is to evaluate test–retest reliability and sensitivity of the VRT paradigm.…”

Section: Test–retest Reliability and Accounting For Measurement Errormentioning

confidence: 99%

Test–Retest Reliability and the Role of Task Instructions when Measuring Listening Effort Using a Verbal Response Time Paradigm

2023

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Listening amidst competing noise taxes one's limited cognitive resources, leading to increased listening effort. As such, there is interest in incorporating a reliable test of listening effort into the clinical test battery. One clinically promising method for measuring listening effort is verbal response time (VRT) because it can be obtained using already-established clinical tasks. In order for widespread implementation of the VRT paradigm, a better understanding of the psychometric properties is needed. The purpose of this work was to improve the understanding of the reliability and sensitivity of the VRT listening task. Using within-subject study designs, we completed a pilot study to evaluate the test–retest reliability (Study 1) and the effects of task instructions and listening condition (Study 2). Preliminary results show that the VRT paradigm enjoys good to excellent test–retest reliability and that neither task instructions nor listening condition meaningfully influence VRT once measurement error is accounted for. Future studies should account for measurement error when considering statistically significant versus meaningful effects of experimental parameters when using listening effort tasks.

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Section: Test–retest Reliability and Accounting For Measurement Errormentioning

confidence: 99%

Test–Retest Reliability and the Role of Task Instructions when Measuring Listening Effort Using a Verbal Response Time Paradigm

2023

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Emerging Interventions for Age-Related Hearing Loss: Review of the CLARITY-1 Trial Through the Description of the Pharmaceutical Development Phases

Sánchez

2018

Perspect ASHA SIGs

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Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design

Prell

2022

Antioxidants & Redox Signaling

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Significance. Noise-induced hearing loss (NIHL) is an important public health issue resulting in decreased quality of life for affected individuals and significant costs to employers and governmental agencies.Recent Advances. Advances in the mechanistic understanding of NIHL have prompted a growing number of proposed, in-progress, and completed clinical trials for possible protections against NIHL via antioxidants and other drug agents. Thirty-one clinical trials evaluating prevention of either temporary or permanent NIHL were identified and are reviewed.Critical Issues. This review revealed little consistency in the noise-exposed populations in which drugs are evaluated or the primary outcomes used to measure NIHL prevention.Changes in pure-tone thresholds were the most common primary outcome; specific threshold metrics included both average hearing loss and incidence of significant hearing loss. Changes in otoacoustic emission (OAE) amplitude were a relatively common secondary outcome. Extended high frequency (EHF) hearing and speech-in-noise perception are commonly adversely affected by noise exposure but are not consistently included in clinical trials assessing prevention of NIHL.Future Directions. Multiple criteria are available for monitoring NIHL, but the specific criterion to be used to define clinically significant otoprotection remains a topic of discussion. Audiogram-based primary outcome measures can be combined with secondary outcomes, including OAE amplitude, EHF hearing, speech-in-noise testing, tinnitus surveys, and patient-reported outcomes. Standardization of test protocols for the above primary and secondary outcomes, and associated reporting criterion for each, would facilitate clinical trial design and comparison of results across investigational drug agents.

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Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

Cited by 3 publications

References 106 publications

Test–Retest Reliability and the Role of Task Instructions when Measuring Listening Effort Using a Verbal Response Time Paradigm

Test–Retest Reliability and the Role of Task Instructions when Measuring Listening Effort Using a Verbal Response Time Paradigm

Emerging Interventions for Age-Related Hearing Loss: Review of the CLARITY-1 Trial Through the Description of the Pharmaceutical Development Phases

Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design

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