Current issues of diagnosis and treatment of osteoporosis in men in general practice

Lesnyak, Olga

doi:10.17816/rfd2017139-44

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…1 out of 5 male patients has a fracture associated with OP [14]. When analyzing risk factors that can cause fractures, experts mostly discuss secondary osteoporosis cases without giving special attention to influence exerted by these factors on risks of fractures in case of primary osteoporosis [15][16][17]. At the same time, according to certain data [18] 80 % osteoporosis cases among men older than 50 are exactly primary osteoporosis.…”

Section: T a B L Ementioning

confidence: 99%

Smoking and alcohol abuse as risk factors causing low-energy fractures in males suffering from primary osteoporosis

Родионова¹,

Хакимов²,

Морозов³

et al. 2020

Health Risk Analysis

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Osteoporosis is a persistent social and medical issue taking into account moral and material losses related to bone fractures occurring against its background. The disease is more frequently examined in women than in men; still, according to EVOS (European Spinal Osteoporosis Study) 13.5 % men older than 50 and 26 % men older than 60 run high risks of fractures in case they have osteoporosis. Risk factors that cause both the disease itself and fractures as its complications have not been examined profoundly, even though men run 1.6 times higher risk of death after a fracture than women. There is an assumption that a reason for this higher mortality is lack of knowledge about risk factors that cause the disease and a fracture as one of its complications. Growing morbidity with osteoporosis among men indicates it is necessary to perform activities aimed at persuading them to pursue healthy lifestyle. Given that, it seems important to assess impacts exerted by smoking and alcohol abuse on risks of fractures among patients with primary osteoporosis bearing in mind prevention of the disease and fractures as its complications. We examined a relation between smoking and alcohol abuse and risks of fractures as osteoporosis markers in 231 patients suffering from primary osteoporosis. We revealed that fractures were authentically more frequent among smoking patients, 90.5 % against 68.1 % (р˂0.001). It was primarily true for fractures of the proximal section in the thigh bone and fractures of vertebral bodies: 20.2 % against 8.8 % and 44.1 % against 27.3 % accordingly. Alcohol abuse also resulted in authentically higher risks of fractures, 89.8 % against 66.2 % accordingly (р˂0.001). Authentic discrepancies were detected only for fractures of vertebral bodies, 43.9 % against 23.6 % accordingly among those who didn't abuse alcohol (р˂0.001). Therefore, we have evidence that there is an authentic relation between smoking and alcohol abuse and risks of fractures of the proximal section in the thigh bone and vertebral bodies. Inclusion of our research results into educational programs may lead to a reduction in frequency of fractures that have the gravest outcomes for health and cause the highest economic losses.

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Section: T a B L Ementioning

confidence: 99%

Smoking and alcohol abuse as risk factors causing low-energy fractures in males suffering from primary osteoporosis

Родионова¹,

Хакимов²,

Морозов³

et al. 2020

Health Risk Analysis

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Changes in the Optical Density of the First Rib and the Coracoid Process of Scapula in Men Depending on Age and Chest Shape According to Computed Tomography

Ladygin,

Yashina,

Klochkova

et al. 2024

Žurnal anatomii i gistopatologii

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The purpose of the study was to evaluate the dynamics of changes in the optical density of bone tissue of the first rib and the base coracoid process of scapula in men of different ages without signs of osteoporosis depending on chest shape. Material and methods. The study was performed on tomograms of the chest of 191 men aged from 20 to 70 years. Measurements on tomograms were carried out in the axial plane using the RadiAnt program. The scans measured the optical density of the first rib tubercle, the distal bony part of the first rib, and the base of scapula coracoid process. All measurements were taken in men randomized by age and chest shape. The results of osteometry were processed by statistical methods. Results. The chest shape determines age-related changes in the optical density of bone tissue. In individuals with intermediate and transverse chest shapes, a decrease in the optical density of bone tissue at the base of scapula coracoid process begins to appear at the age of 30–50 years. These changes are most pronounced for the base of coracoid process, regardless of the chest shape, at the age of over 50 years. A decrease in the optical density of the first rib tubercle manifests over the age of 50 years in individuals with intermediate and transverse chest shape. In individuals with a gracile chest shape, the optical density of the bone structure is more stable. The tubercle of the first rib, along with the base of coracoid process, can serve as a prognostic area in the diagnosis of systemic osteoporosis in individuals with transverse and intermediate chest shape. Conclusion. A deterministic approach to the described indicators of changes in the optical density of bone tissue of the first rib and scapula in individuals with different chest shapes, according to SCT tomograms, objectively helps to predict and subsequently verify the manifestations of osteoporosis. The dependences we have identified on changes in bone tissue density and in the structure of correlations between the studied parameters of the first rib and the coracoid process indicate pronounced somatotypic variability, which must be taken into account when developing restorative treatment and predicting the course of orthopedic diseases in people of different age.

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Risk Factors of Bone Mineral Density Deficit and Low-Energy Fractures in Primary Osteoporosis in Men

Родионова

Хакимов

2018

Vestn. travmatol. ortop. im. N.N. Priorova

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Purpose:to evaluate the role of well-known factors on the formation of bone mineral density (BMD) and risk of fractures in primary osteoporosis in men.Patients and methods.The influence of well-known osteoporosis risk factors such as age, smoking, alcohol consumption, obesity, genetic disorders in genes encoding COL1A1, COL1A2 and VDR-receptor products, history of low-energy fractures in first-line relatives upon the BMD value and risk of fractures was evaluated in 231 patients with primary osteoporosis. All patients were divided into three age groups according to the following forms of osteoporosis: 17-20 years (n=26) – juvenile form, 21-50 (n=103) – idiopathic form, patients over 51 years (n=102). To assess the influence of study factors on the risk of fractures the patients were subdivided into 5 groups according to fracture localization.Results.The relationship between BMD deficit and mutations in homozygous form of gene rs2412298 (encodes collagen), and the tendency to a reliable increase of BMD deficit in L1 – L4 vertebrae under polymorphism in homozygous form of 1800012 gene was noted that might be evidence of their contribution to the development of primary osteoporosis in men. At the same time, smoking, alcohol consumption, age, mutations in homozygous form of gene rs2412298 and a history of low-energy fractures in first-line relatives increased the risk of low-energy fractures of the vertebral bodies and proximal femur.

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Current issues of diagnosis and treatment of osteoporosis in men in general practice

Cited by 3 publications

References 14 publications

Smoking and alcohol abuse as risk factors causing low-energy fractures in males suffering from primary osteoporosis

Smoking and alcohol abuse as risk factors causing low-energy fractures in males suffering from primary osteoporosis

Changes in the Optical Density of the First Rib and the Coracoid Process of Scapula in Men Depending on Age and Chest Shape According to Computed Tomography

Risk Factors of Bone Mineral Density Deficit and Low-Energy Fractures in Primary Osteoporosis in Men

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