Current Knowledge on Honey and Its Derivatives with Genomic Stability: A Mini Review

Abstract

Genome health is an important factor that plays a role in various degenerative diseases. Instability of genome is the prevalence of mutation within the genome such as changed in nucleic acid and chromosomal arrangement and also the presence of abnormal number of chromosome in cell. Therefore, several method were used to overcome this problem and one of them is by using natural product such as honey, propolis, bee pollen and royal jelly that is high in antioxidant. Those are products that derive from honey bee and had been used as food supplement to increase the quality of life. Therefore, this systematic review provides the updates on the potential of honey bee products to decrease DNA damage both in in vivo and in vitro approaches. Search term of "honey", "propolis", "bee pollen", royal jelly", "DNA damage", "genome integrity", and "telomere" were used for searching purpose in three databases (Scopus, Pubmed and Medline) and also Google Scholar. All the published articles were assessed using PRISMA guidelines and finally after the eligibility process, only 34 published articles were selected for this review. Based on the reports, the product from the honey bee decrease the genome related diseases by reducing the accumulation of free radical, increase the DNA repair protein expression and decrease the telomerase activity in the cell. This provides a large gap in the research field focusing on the effect of those derivatives from bees on genomic stability.

The stingless bee honey protects against hydrogen peroxide-induced oxidative damage and lipopolysaccharide-induced inflammation in vitro

“…It has been known that oxidative stress is one of the major causes of mutation and is involved in all stages of carcinogenesis during neoplasm formation ( Kryston et al, 2011 ). Recent studies have shown that oxidative stress can cause genomic instability and gene silencing in cells, thus leading to the progression of degenerative diseases and speed up the aging process in the body ( Lombard et al, 2005 , Lu et al, 2004 , Yaacob et al, 2017 ).…”

Protective Effects of Arbutus unedo L. Honey in the Alleviation of Irinotecan-Induced Cytogenetic Damage in Human Lymphocytes—An In Vitro Study

“…Not many studies have, up to now, investigated the influence of honey at the genome and cell level. In 2017, Yaacob et al [15] published an extensive review that provides good insight into the existing studies that investigated the association between honey and genomic stability. Evidently, there is no specific rationale for investigating and establishing the protective effects for well-known honey types that humankind has used since ancient times.…”

Determination of Antibacterial and DNA Damage Inhibitory Activities of Propolis Extract from Izmir of Turkey

“…For this reason, numerous studies led to the differentiation of biological activity results related to propolis [8]. This natural product has been widely used for a variety of purposes in folk medicine as cardiovascular and gastrointestinal disease, respiratory tract infections, immune system support, antioxidant anti-inflammatory, antimicrobial, and antiviral agent [3,9,10,11]. Moreover, in recent years there are also several studies related to the antigenotoxic activity of propolis [12,13,14,15].…”