Current knowledge on mechanisms involved in SARS-CoV-2 infection and kidney diseases

Rahman, Md. Hasanur; Zahan, Md. Sarwar; Hasib, Tasnin Al; Ahmed, Kazi Ahsan; Khanam, Mansura; Omit, S.; Moni, A.; Uddin, Jamal

doi:10.5455/jabet.2020.d153

Cited by 4 publications

(4 citation statements)

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“…Many reports showed that SARS-CoV-2 might cause direct kidney injury due to the high expression of ACE2 in the renal tissue, and multiple factors such as endothelial cell injury, host immune clearance, and immune tolerance disorders, and lipid metabolic disorders, etc. promote kidney injury [ 7 , 23 , 24 ]. Previous reports also suggested that the newly identified SARS-CoV-2 host factor NRP1 mRNA and protein expression in the kidney also control the integrity of the glomerular basement membrane [ 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…ACE2 is reported to be a receptor for SARS-CoV-2 in kidney injury, while, recently, NRP1 has been identified as a potential host factor for SARS-CoV-2, and NRP1 specifically binds with the C-end rule (CendR) motif of the S1 subunit of the spike protein [ 6 , 7 ]. Moreover, inhibiting this binding by monoclonal antibodies, small-molecule inhibitors, or RNA interference significantly reduced the SARS-CoV-2 entry in the cell culture, suggesting a potential therapeutic target for COVID-19 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis

Hossain

Akter

Uddin

2021

Infectious Disease Reports

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Neuropilin-1 (NRP1) is a recently identified glycoprotein that is an important host factor for SARS-CoV-2 infection. On the other hand, angiotensin-converting enzyme-2 (ACE2) acts as a receptor for SARS-CoV-2. Additionally, both NRP1 and ACE2 express in the kidney and are associated with various renal diseases, including renal carcinoma. Therefore, the expression profiles of NRP1 and ACE2 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) patients from the various cancer databases were investigated along with their impact on patients’ survivability. In addition, coexpression analysis of genes involved in COVID-19, KIRC, and KIRP concerning NRP1 and ACE2 was performed. The results demonstrated that both t NRP1 and ACE2 expressions are upregulated in KIRC and KIRP compared to healthy conditions and are significantly correlated with the survivability rate of KIRC patients. A total of 128 COVID-19-associated genes are coexpressed, which are positively associated with NRP1 and ACE2 both in KIRC and KIRP. Therefore, it might be suggested that, along with the ACE2, high expression of the newly identified host factor NRP1 in renal carcinomas may play a vital role in the increased risk of SARS-CoV-2 infection and survivability of COVID-19 patients suffering from kidney cancers. The findings of this investigation will be helpful for further molecular studies and prevention and/or treatment strategies for COVID-19 patients associated with renal carcinomas.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis

Hossain

Akter

Uddin

2021

Infectious Disease Reports

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“…Patients with severe COVID-19 often exhibit electrolyte and acidbase imbalance, diarrhea, disseminated intravascular coagulation, and heart failure. Acute kidney injury and concomitant endothelial damage, glomerular hypertension, interstitial infiltration, and fibrosis are major factors leading to chronic renal failure after an episode of acute kidney injury (26). The chronic conditions that affect the immune system include heart disease; asthma, lupus, and diabetes increase the burden of morbidity and mortality associated with COVID-19 (27).…”

Section: Aggravating Factors Of Acute Kidney Injurymentioning

confidence: 99%

COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2

et al. 2020

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Coronavirus disease 2019 (COVID-19) is an ongoing pandemic, reported to cause asymptomatic to severe disease and eventually death. Multi-organ failure and death in patients with severe COVID-19 is associated with increased release of pro-inflammatory cytokines into the blood stream. Renal impairment is reported in a significant proportion of COVID-19 patients and is associated with high mortality. Acute kidney injury (AKI) is multifactorial and involving overlapping pathogenic mechanisms. This review updates the reader of recent publications dealing with the mechanisms underlying AKI in patients with COVID-19. A full understanding of all the possible ways in which the system plays its role in AKI is still a matter of research. Further studies are warranted to better understand the causes of AKI in COVID-19 patients.

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“…Sometimes abdominal discomfort and diarrhea or neurological presentation, including delirium, might be recorded [ 11 , 23 ]. In critical patients, the infection might present as disseminated intravascular coagulation (DIC) or acute kidney injury (AKI) [ 27 , 28 ]. Infection of the lower respiratory tract might present as viral pneumonia, Severe Acute Respiratory Infection (SARI), or even progresses to multiple organ failure (MOF) [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview

Gorący

Rosik

Szostak

et al. 2022

Viruses

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Since the end of 2019, the whole world has been struggling with the life-threatening pandemic amongst all age groups and geographic areas caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). The Coronavirus Disease 2019 (COVID-19) pandemic, which has led to more than 468 million cases and over 6 million deaths reported worldwide (as of 20 March 2022), is one of the greatest threats to human health in history. Meanwhile, the lack of specific and irresistible treatment modalities provoked concentrated efforts in scientists around the world. Various mechanisms of cell entry and cellular dysfunction were initially proclaimed. Especially, mitochondria and cell membrane are crucial for the course of infection. The SARS-CoV-2 invasion depends on angiotensin converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and cluster of differentiation 147 (CD147), expressed on host cells. Moreover, in this narrative review, we aim to discuss other cell organelles targeted by SARS-CoV-2. Lastly, we briefly summarize the studies on various drugs.

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Current knowledge on mechanisms involved in SARS-CoV-2 infection and kidney diseases

Cited by 4 publications

References 0 publications

Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis

Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis

COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2

Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview

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