Current knowledge on therapeutic, diagnostic, and prognostics applications of exosomes in multiple myeloma: Opportunities and challenges

Ramezani, Aghdas; Tafazoli, Aida; Salimi, Fatemeh; Ghavami, Mahlegha; Arjmandi, Hanie; Khalesi, Bahman; Hashemi, Zahra Sadat; Khalili, Saeed

doi:10.1016/j.abb.2024.109994

Archives of Biochemistry and Biophysics

2024

DOI: 10.1016/j.abb.2024.109994

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Current knowledge on therapeutic, diagnostic, and prognostics applications of exosomes in multiple myeloma: Opportunities and challenges

Aghdas Ramezani,

Aida Tafazoli,

Fatemeh Salimi

et al.

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2024

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Exosomal ncRNAs in reproductive cancers

Kowalczyk,

Wrzecińska,

Gałęska

et al. 2024

Biology of Reproduction

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Extracellular vesicles, particularly exosomes, play a pivotal role in the cellular mechanisms underlying cancer. This review explores the various functions of exosomes in the progression, growth, and metastasis of cancers affecting the male and female reproductive systems. Exosomes are identified as key mediators in intercellular communication, capable of transferring bioactive molecules such as miRNAs, proteins, and other nucleic acids that influence cancer cell behavior and tumor microenvironment interactions. It has been shown that nc-RNAs transported by exosomes play an important role in tumor growth processes. Significant molecules that may serve as biomarkers in the development and progression of male reproductive cancers include miR-125a-5p, miR-21, miR-375, the miR-371 ~ 373 cluster, and miR-145-5p. For female reproductive cancers, significant miRNAs include miR-26a-5p, miR-148b, miR-205, and miRNA-423-3p. This review highlights the potential of these ncRNAs as biomarkers and prognostics in tumor diagnostics. Understanding the diverse roles of exosomes may hold promise for developing new therapeutic strategies and improving treatment outcomes for cancer patients.

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Exosomal ncRNAs in reproductive cancers

Kowalczyk,

Wrzecińska,

Gałęska

et al. 2024

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

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Current knowledge on therapeutic, diagnostic, and prognostics applications of exosomes in multiple myeloma: Opportunities and challenges

Cited by 1 publication

References 122 publications

Exosomal ncRNAs in reproductive cancers

Exosomal ncRNAs in reproductive cancers

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