Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens

Haque, Ehfazul; Kamal, Mir Shahriar; Tahsin, Rafat; Ahmed, Raju; Choudhury, Jakir Ahmed; Choudhury, Abu Asad; Kabir, Shaila; Amran, Shah; Uddin, Sahab

doi:10.2174/1568026621666211004094902

Cited by 4 publications

(4 citation statements)

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“…Of the 76 phytoconstituents of G. procumbens, 11 were alkaloids, 32 were phenolic compounds, 13 were flavonoids, 15 were steroidal compounds, and 5 were terpenes [78]. The compounds with their respective compound IDs (to be used henceforth in this manuscript) are presented in Table 3.…”

Section: Results Of In Silico Studymentioning

confidence: 99%

“…However, predominant flavonoids kaempferol-3-O-rutinoside, and myricetin have great scavenging capacity of DPPH and ABTS+ radicals. Since CCl4 increases cellular necrosis of the liver by generating free radicals, it may be postulated that the presence of flavonoids in Gynura procumbens scavenges these free radicals and gradually reduces the cellular necrosis of the liver [108][109][110][111]. Overall, Gynura procumbens might be a promising, clinically applicable, natural counteraction against drug-induced side effects when long-term or multiple drug therapy is required for a potent hepatoprotective action.…”

Section: Plos Onementioning

confidence: 99%

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An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

Tithi,

Tahsin,

Anjum

et al. 2023

PLoS ONE

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Introduction The liver, the most important metabolic organ of the body, performs a wide variety of vital functions. Hepatic cell injury occurs by the activation of reactive oxygen species (ROS) that are generated by carbon tetrachloride (CCl4), xenobiotics, and other toxic substances through cytochrome P450-dependent steps resulting from the covalent bond formation with lipoproteins and nucleic acids. Observing the urgent state of hepatotoxic patients worldwide, different medicinal plants and their properties can be explored to combat such free radical damage to the liver. In vivo and in silico studies were designed and conducted to evaluate the antioxidant and hepatoprotective properties of Gynura procumbens in rats. Materials and methods Gynura procumbens leaves were collected and extracted using 70% ethanol. The required chemicals CCl4, standard drug (silymarin), and blood serum analysis kits were stocked. The in vivo tests were performed in 140 healthy Wister albino rats of either sex under well-controlled parameters divided into 14 groups, strictly maintaining Institutional Animal Ethics Committee (IEAC) protocols. For the histopathology study, 10% buffered neutral formalin was used for organ preservation. Later the specimens were studied under a fluorescence microscope. In silico molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies were performed, and the results were analyzed statistically. Results and discussion Gynura procumbens partially negate the deleterious effect of carbon tetrachloride on normal weight gain in rats. The elevated level of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), creatinine, LDH, total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), malondialdehyde (MDA), deoxyribonucleic acid (DNA) fragmentation ranges, gamma-glutamyl transferase (γ-GT) in CCl4 treated groups were decreased by both standard drug silymarin and G. procumbens leaf extract. We have found significant & highly significant changes statistically for different doses, here p<0.05 & p<0.01, respectively. On the other hand, G. procumbens and silymarin displayed Statistically significant (p<0.05) and high significant(p<0.01) increased levels of HDL, CAT SOD (here p<0.05 & p<0.01 for different doses) when the treatment groups were compared with the disease control group. Because the therapeutic activity imparted by plants and drugs accelerates the movement of the disturbed pathophysiological state toward the healthy state. In the molecular docking analysis, G. procumbens phytoconstituents performed poorly against transforming growth factor-beta 1 (TGF-β1) compared to the control drug silymarin. In contrast, 26 phytoconstituents scored better than the control bezafibrate against peroxisome proliferator-activated receptor alpha (PPAR-α). The top scoring compounds for both macromolecules were observed to form stable complexes in the molecular dynamics simulations. Flavonoids and phenolic compounds performed better than other constituents in providing hepatoprotective activity. It can, thus, be inferred that the extract of G. procumbens showed good hepatoprotective properties in rats.

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Section: Results Of In Silico Studymentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

Tithi,

Tahsin,

Anjum

et al. 2023

PLoS ONE

Self Cite

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“…Of the 76 phytoconstituents of G. procumbens , 11 were alkaloids, 32 phenolic compounds, 13 flavonoids, 15 steroidal compounds, and 5 terpenes [51]. The compounds with their respective compound IDs (to be used henceforth on this manuscript) are presented in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

An in vivo and in silico evaluation of the magical hepatoprotective potentialities of Gynura procumbens: a promising agent for combating hepatotoxicity

Tithi

Tahsin

Zaman

et al. 2022

Preprint

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IntroductionLiver being the most important metabolic organ of the body performs a wide variety of vital functions. Hepatic cell injury occurs by the activation of reactive oxygen species (ROS) by CCl4, xenobiotics and other toxic substances generated through cytochrome P450 dependent step resulting from covalent bond formation with lipoproteins and nucleic acids. Observing the alarming state of hepatotoxic patients worldwide, different medicinal plants and their properties can be explored to combat against such free radical degermation of liver. This paper evaluates the antioxidant property of Gynura procumbens in both in silico and in an in vivo assay, and its hepatoprotective activity in CCl4 induced hepatotoxicity.Materials and MethodsGynura procumbens leaves were collected and extracted using 50% ethanol. Required chemicals (CCl4), standard drug (Silymarin) and blood serum analyzing kits were stocked. The in vivo tests were performed in 140 healthy Wister albino male rats under well controlled parameters dividing into 14 groups, strictly maintaining IEAC protocols. In silico molecular docking and ADMET studies were performed and the results were analyzed statistically.Results and discussionThe body weight increased significantly in CCl4 induced, G. procumbens administered hepatotoxic rats. The increase in SGPT, SGOT, ALP, creatinine, LFH, triglycerides, LDL, SOD, MDA, total cholesterol, DNA fragmentation ranges, γGT levels of CCl4 treated group was decreased by both standard drug Silymarin and G. procumbens leaf extract. On the other hand, G. procumbens increased HDL levels and displayed contrasting results in CAT level tests. Some results contradicted with the negative controlled group displaying varying efficacy between leaf extract and Silymarin. In the molecular docking analysis, G. procumbens phytoconstituents performed poorly against TGF-β1 compared to the control drug Galunisertib while 26 phytoconstituents scored better than the control, bezafibrate against PPAR-α. Flavonoids and phenolic compounds performed better than other constituents in providing hepatoprotective activity.

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“…The leaves of G. procumbens contain anti-herpes simplex virus, antihyperglycemic, anti-inflammatory, antihyperlipidemic, anti-allergy agent, and antihypertensive properties [ 68 ]. Apart from its antihypertensive, glucose-lowering, and anti-inflammatory properties, it is also a source of proteins and peroxidase [ 69 ]. G. procumbens leaves contain essential oil, flavonoids, miraculin, polyphenols, peroxidase, thaumatin-like proteins, terpenoids, and unsaturated sterols.…”

Section: Potentialities Of Endophytic Bacteriamentioning

confidence: 99%

Sustainable Applications of Endophytic Bacteria and Their Physiological/Biochemical Roles on Medicinal and Herbal Plants: Review

2023

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Bacterial endophytes reside within the tissues of living plant species without causing any harm or disease to their hosts. These endophytes can be isolated, identified, characterized, and used as biofertilizers. Moreover, bacterial endophytes increase the plants’ resistance against diseases, pests, and parasites, and are a promising source of pharmaceutically important bioactives. For instance, the production of antibiotics, auxins, biosurfactants, cytokinin’s, ethylene, enzymes, gibberellins, nitric oxide organic acids, osmolytes, and siderophores is accredited to the existence of various bacterial strains. Thus, this manuscript intends to review the sustainable applications of endophytic bacteria to promote the growth, development, and chemical integrity of medicinal and herbal plants, as well as their role in plant physiology. The study of the importance of bacterial endophytes in the suppression of diseases in medicinal and herbal plants is crucial and a promising area of future investigation.

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Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens

Cited by 4 publications

References 97 publications

An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

An in vivo and in silico evaluation of the magical hepatoprotective potentialities of Gynura procumbens: a promising agent for combating hepatotoxicity

Sustainable Applications of Endophytic Bacteria and Their Physiological/Biochemical Roles on Medicinal and Herbal Plants: Review

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