Current material engineering strategies to prevent catheter encrustation in urinary tracts

Yao, Qing; Wu, Chengshuai; Chen, Xu; Pan, Guoqing; Chen, Binghai

doi:10.1016/j.mtbio.2022.100413

Cited by 12 publications

(8 citation statements)

References 133 publications

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Section: Introductionmentioning

confidence: 99%

“…[ 12 ] The drug‐impregnated urinary catheters and ureteral stents are commercially available technologies for bacterial infection and infectious encrustation. [ 6 ] However, antibiotic resistance limits the development of this strategy. [ 13 ] Antimicrobial peptides and quaternary ammonium salts have also been developed and applied to urological devices.…”

Section: Introductionmentioning

confidence: 99%

“…[5] Severe encrustations of urinary catheters or ureteral stents can obstruct the urinary tract system and cause infected urine reflux, triggering symptoms such as pyelonephritis, endotoxin shock, and sepsis. [6] Bacterial infections are usually caused by bacterial adhesion and biofilm formation on implant surfaces. [7] Unlike bacterial infections, device-related encrustation occurs only in the urinary system, and limited studies have shown that: (1) metabolic encrustation is mainly dominated by calcium oxalate owing to metabolic disorders (obesity, hypertension, hyperglycemia, etc.).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Salt‐Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti‐Multiple Encrustations in Urological Devices

Shi

Zhu

et al. 2023

Adv Healthcare Materials

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Bacterial infections and multiple encrustations are life‐threatening complications in patients implanted with urological devices. Limited by time‐consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design of a salt‐triggered chondroitin sulfate complex (CS/Si‐N+) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti‐multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensures the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si‐N+ coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity are more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibits broad‐spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibits significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non‐leachable all‐in‐one coating shows good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device‐related complications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Salt‐Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti‐Multiple Encrustations in Urological Devices

Shi

Zhu

et al. 2023

Adv Healthcare Materials

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“…3 Therefore, the development of effective strategies to inhibit bacterial colonization and bacteria-inducing encrustation in urinary catheters is highly desired. 4,5 This journal is © The Royal Society of Chemistry 2023…”

Section: Introductionmentioning

confidence: 99%

Multifunctional hydrogel coatings with high antimicrobial loading efficiency and pH-responsive properties for urinary catheter applications

et al. 2023

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“…[ 3b,6 ] After modification, the hydrated lubricant surface can prevent the adhesion/deposition of multiple biofouling factors and thus inhibit biofilm formation as well as bestow a beneficial lubricant effect, resulting in a decrease in the incidence of UTIs and encrustation. [ 7 ] Currently, hydrophilic lubricant coatings are commercially available in the USs market and, compared with uncoated USs, exhibit improved performance in preventing stent‐associated complications. [ 3b,8 ] However, for long‐term treatment, it is still very difficult to effectively prevent biofilm formation via the single antifouling function of these lubricant coatings due to the passive antibiofilm mechanism.…”

Section: Introductionmentioning

confidence: 99%

Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

Li,

Tang,

Peng

et al. 2023

Adv Funct Materials

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Hydrophilic lubricant coatings with antifouling properties are commercially applied to urological devices, such as ureteral stents (USs), to inhibit biofilm formation and reduce the likelihood of infectious encrustation. However, their long‐term effectiveness is limited due to the lack of active and precise antibacterial activity. Herein, this work reports a hydrophilic lubricant (defined as SA‐PU/PVP) coating with smart urease‐responsive antibiotic release functionality, achieved by incorporating the antibiotic sulfanilamide‐conjugated polyurethane (SA‐PU) polymers into a commercial lubricant coating agent containing hydrophilic polyvinylpyrrolidone (PVP). During the initial implantation period, the hydrophilic PVP chains rapidly absorb urine on the coating interface, forming a lubricating layer with the desired antifouling activities that reduce the attachment of host proteins, bacteria, and urate crystals by over 90%. As time progresses and the bacteria proliferates and produces urease, the urease enzymatically degrades the urea linkages in the SA‐PU/PVP coating, actively releasing SA antibiotics on demand to prevent biofilm formation and encrustation. Benefiting from this synergistic antifouling and smart antibacterial activities, the SA‐PU/PVP‐coated US exhibits superior performance in preventing infectious encrustation in a porcine model over a 7‐week period, surpassing the effectiveness of a commercial hydrophilic lubricant US. This coating strategy offers a practical solution for inhibiting urological device‐associated complications.

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Current material engineering strategies to prevent catheter encrustation in urinary tracts

Cited by 12 publications

References 133 publications

Salt‐Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti‐Multiple Encrustations in Urological Devices

Salt‐Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti‐Multiple Encrustations in Urological Devices

Multifunctional hydrogel coatings with high antimicrobial loading efficiency and pH-responsive properties for urinary catheter applications

Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

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