2005
DOI: 10.1111/j.1440-1681.2005.04268.x
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Current models of human prostate contractility

Abstract: SUMMARY1. The human prostate is a compact gland contributing to seminal fluid. With increasing age, most humans will develop benign prostatic hyperplasia, a condition of prostatic enlargement and contractility that leads to occlusion of the urethra. Over many years, investigators have used a variety of animal and cell culture models to elucidate some of the contractile and proliferative mechanisms that may be associated with the development of this condition.2. This review briefly assesses the current state of… Show more

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Cited by 16 publications
(17 citation statements)
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“…There was evidence for adrenergic, muscarinic, and purinergic excitatory innervations to the human prostate. This is at variance with other reports, which reported at most two identifiable neurotransmitters in humans . Most interestingly, the mean values of individual reductions of EFS contractions by atropine, prazosin, and ABMA were consistently >100%.…”
Section: Discussioncontrasting
confidence: 90%
See 1 more Smart Citation
“…There was evidence for adrenergic, muscarinic, and purinergic excitatory innervations to the human prostate. This is at variance with other reports, which reported at most two identifiable neurotransmitters in humans . Most interestingly, the mean values of individual reductions of EFS contractions by atropine, prazosin, and ABMA were consistently >100%.…”
Section: Discussioncontrasting
confidence: 90%
“…This is at variance with other reports, which reported at most two identifiable neurotransmitters in humans [8][9][10][11][12][13][14]. Most interestingly, the mean values of individual reductions of EFS contractions by atropine, prazosin, and ABMA were consistently >100%.…”
Section: Discussioncontrasting
confidence: 86%
“…In the hyperplasic prostate the increase in tone of the prostate is mediated, in part, by neuronal noradrenaline acting at α 1L -adrenoceptors to cause smooth muscle contraction and this mechanism forms the basis for the treatment of BPH with α 1 -adrenoceptor antagonists. However, prostatic smooth muscle contraction is also mediated by numerous other receptor systems, 74 , 121 such as acetylcholine acting at muscarinic receptors or ATP acting at purinoceptors. Therefore, blockade of these receptors, particularly muscarinic receptors, has been hypothesized as a suitable additional target for a better pharmacological treatment for BPH 122 .…”
Section: Effects Of Bph On Prostate Innervationmentioning
confidence: 99%
“…The smooth muscle tone of the prostate gland is controlled predominantly by neuronally released noradrenaline acting at ␣ 1A adrenoceptors in humans, guinea pigs, and rats (Haynes and Ventura, 2005) and mice (Gray and Ventura, 2006). This therefore forms the basis for the use of selective ␣ 1A -adrenoceptor antagonists for the treatment of BPH (Cooper et al, 1999;Lepor, 2007).…”
Section: Introductionmentioning
confidence: 99%