Current Molecular, Cellular and Genetic Aspects of Peri-Implantitis Disease: A Narrative Review

Chmielewski, Marek; Pilloni, Andrea

doi:10.3390/dj11050134

Cited by 11 publications

(4 citation statements)

References 93 publications

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“…This inspired researchers to explore the correlation between certain genetic polymorphisms and their interaction with implants. It was discovered that certain genetic defects in pro-inflammatory markers are directly associated with increased peri-implant bone destruction [ 208 , 209 ]. The growing frequency of observations indicating that individual patient characteristics, including genetic polymorphisms in molecules crucial to inflammation, the extracellular matrix, bone remodeling, and coagulation, etc., could pave the way for a new area of study in biomaterials science [ 210 ] that we can call ‘biomateriogenomics’.…”

Section: Mechanisms Of Host-biomaterials Interactionmentioning

confidence: 99%

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan,

Krieg,

Kopp

et al. 2024

IJMS

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Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models.

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Section: Mechanisms Of Host-biomaterials Interactionmentioning

confidence: 99%

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan,

Krieg,

Kopp

et al. 2024

IJMS

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“…Metals are not new in dentistry. However, metals are materials with no biological activity, which contributes to their limited attractiveness as biomaterials [16]. During the last three decades, remarkable technological breakthroughs in ceramics and polymers have permitted their usage in medical devices.…”

Section: Implant Surface Modificationsmentioning

confidence: 99%

Biomimetic Coatings in Implant Dentistry: A Quick Update

Abdulghafor,

Mahmood,

Tassery

et al. 2023

JFB

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Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface’s chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied to improve osseointegration and decrease peri-implantitis. The surface medication increases surface energy, leading to enhanced cell proliferation and growth factors, and, consequently, to a rise in the osseointegration process. This review provides a comprehensive update on the numerous biomimetic coatings used to improve the surface characteristics of dental implants and their applications in two main categories: coating to improve osseointegration, including the hydroxyapatite layer and nanocomposites, growth factors (BMPs, PDGF, FGF), and extracellular matrix (collagen, elastin, fibronectin, chondroitin sulfate, hyaluronan, and other proteoglycans), and coatings for anti-bacterial performance, covering drug-coated dental implants (antibiotic, statin, and bisphosphonate), antimicrobial peptide coating (GL13K and human beta defensins), polysaccharide antibacterial coatings (natural chitosan and its coupling agents) and metal elements (silver, zinc, and copper).

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“…All are placed transmucosally or mucosally with the expectation that gingival soft tissue will adhere, grow, and cover them to seal the zirconia interface and prevent bacterial invasion from the oral cavity. Nevertheless, periodontal disease and periimplantitis caused by bacterial infection are primary and increasing causes of tooth and implant failure [26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Indeed, gingival tissue rarely fully adheres to zirconia or titanium surfaces in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Vacuum Ultraviolet (VUV) Light Photofunctionalization to Induce Human Oral Fibroblast Transmigration on Zirconia

Suzumura,

Matsuura,

Komatsu

et al. 2023

Cells

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Soft tissue adhesion and sealing around dental and maxillofacial implants, related prosthetic components, and crowns are a clinical imperative to prevent adverse outcomes of periodontitis and periimplantitis. Zirconia is often used to fabricate implant components and crowns. Here, we hypothesized that UV treatment of zirconia would induce unique behaviors in fibroblasts that favor the establishment of a soft tissue seal. Human oral fibroblasts were cultured on zirconia specimens to confluency before placing a second zirconia specimen (either untreated or treated with one minute of 172 nm vacuum UV (VUV) light) next to the first specimen separated by a gap of 150 µm. After seven days of culture, fibroblasts only transmigrated onto VUV-treated zirconia, forming a 2.36 mm volume zone and 5.30 mm leading edge. Cells migrating on VUV-treated zirconia were enlarged, with robust formation of multidirectional cytoplastic projections, even on day seven. Fibroblasts were also cultured on horizontally placed and 45° and 60° tilted zirconia specimens, with the latter configurations compromising initial attachment and proliferation. However, VUV treatment of zirconia mitigated the negative impact of tilting, with higher tilt angles increasing the difference in cellular behavior between control and VUV-treated specimens. Fibroblast size, perimeter, and diameter on day seven were greater than on day one exclusively on VUV-treated zirconia. VUV treatment reduced surface elemental carbon and induced superhydrophilicity, confirming the removal of the hydrocarbon pellicle. Similar effects of VUV treatment were observed on glazed zirconia specimens with silica surfaces. One-minute VUV photofunctionalization of zirconia and silica therefore promotes human oral fibroblast attachment and proliferation, especially under challenging culture conditions, and induces specimen-to-specimen transmigration and sustainable photofunctionalization for at least seven days.

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Current Molecular, Cellular and Genetic Aspects of Peri-Implantitis Disease: A Narrative Review

Cited by 11 publications

References 93 publications

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Biomimetic Coatings in Implant Dentistry: A Quick Update

Vacuum Ultraviolet (VUV) Light Photofunctionalization to Induce Human Oral Fibroblast Transmigration on Zirconia

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