Current Perspective on the Natural Compounds and Drug Delivery Techniques in Glioblastoma Multiforme

Behl, Tapan; Sharma, Aditi; Sharma, Lalit; Sehgal, Aayush; Singh, Sukhbir; Sharma, Neelam; Zengin, Gökhan; Bungău, Simona; Toma, Mirela Mărioara; Gîtea, Daniela; Babeş, Elena Emilia; Pusta, Claudia Teodora Judea; Bumbu, Adrian Gheorghe

doi:10.3390/cancers13112765

Cited by 48 publications

(14 citation statements)

References 220 publications

(235 reference statements)

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“…Further studies analyzing the real food intake of oncological patients are needed because previous studies have suggested potential sources of natural products with an important role on inflammation in cancer and COVID-19 patients [51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown

et al. 2022

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Many studies have demonstrated that malnutrition has a negative impact on quality of life and mortality in patients with cancer. During the SARS-CoV-2 lockdown, dietary intake changes were detected in the Spanish population, reflecting an increase in the consumption of fruit, bread, flours, and eggs. The present study analyzed the nutritional status of 728 patients with cancer admitted once the SARS-CoV-2 lockdown finished, comparing it with the previous year as well as with mortality rates. The Malnutrition Universal Screening Tool (MUST) was applied in the first 24 h after admission. Age, gender, days of stay, circulating concentrations of albumin, cholesterol, C-reactive protein (CRP), lymphocytes, prealbumin, and mortality data were analyzed. Patients with cancer admitted between June and December of 2020 exhibited no statistical differences in BMI, age, or gender as compared to patients admitted in 2019. Statistically significant differences in nutritional status (p < 0.05), albumin (p < 0.001), and CRP (p = 0.005) levels regarding lockdown were observed in relation with a small non-significant reduction in mortality. In conclusion, following the SARS-CoV-2 lockdown, an improved nutritional status in cancer patients at admission was observed with a decrease in the percentage of weight loss and CRP levels together with an increase in albumin levels compared to oncological patients admitted the previous year.

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Section: Discussionmentioning

confidence: 99%

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown

et al. 2022

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“…GIT issues such diarrhea and colitis have also been documented in 30-40% of those who have been given anti-CTLA-4 antibodies [73]. Some of the less prevalent adverse effects, such as endocrine, nephritis, pancreatitis, and neurological diseases, should not be overlooked [59,[87][88][89][90][91].…”

Section: Diversitymentioning

confidence: 99%

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

et al. 2022

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Immunotherapy, which stimulates the body’s immune system, has received a considerable amount of press in recent years because of its powerful benefits. Cancer immunotherapy has shown long-term results in patients with advanced disease that are not seen with traditional chemotherapy. Immune checkpoint inhibitors, cytokines like interleukin 2 (IL-2) and interferon-alpha (IFN), and the cancer vaccine sipuleucel-T have all been licensed and approved by the FDA for the treatment of various cancers. These immunotherapy treatments boost anticancer responses by stimulating the immune system. As a result, they have the potential to cause serious, even fatal, inflammatory and immune-related side effects in one or more organs. Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell therapy are two immunotherapy treatments that are increasingly being used to treat cancer. Following their widespread usage in the clinic, a wave of immune-related adverse events (irAEs) impacting virtually every system has raised concerns about their unpredictability and randomness. Despite the fact that the majority of adverse effects are minimal and should be addressed with prudence, the risk of life-threatening complications exists. Although most adverse events are small and should be treated with caution, the risk of life-threatening toxicities should not be underestimated, especially given the subtle and unusual indications that make early detection even more difficult. Treatment for these issues is difficult and necessitates a multidisciplinary approach involving not only oncologists but also other internal medicine doctors to guarantee quick diagnosis and treatment. This study’s purpose is to give a fundamental overview of immunotherapy and cancer-related side effect management strategies.

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“…Natural product research has been revolutionized by high-throughput technologies and rapidly accumulating experimental evidence has unveiled mechanistic analysis of pharmacological properties of myriad of high-quality bioactive components (58)(59)(60)(61). Schisandrin has been reported to be effective in the treatment of different diseases.…”

Section: Future Prospectsmentioning

confidence: 99%

Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"

Lin

Attar

Mobeen³

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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There has been an exponential growth in the field of molecular oncology and cutting-edge research has enabled us to develop a better understanding of therapeutically challenging nature of cancer. Based on the mechanistic insights garnered from decades of research, puzzling mysteries of multifaceted nature of cancer have been solved to a greater extent. Our rapidly evolving knowledge about deregulated oncogenic cell signaling pathways has allowed us to dissect different oncogenic transduction cascades which play critical role in cancer onset, progression and metastasis. Pharmacological targeting of deregulated pathways has attracted greater than ever attention in the recent years. Henceforth, discovery and identification of high-quality biologically active chemicals and products is gaining considerable momentum. There has been an explosion in the dimension of natural product research because of tremendous potential of chemopreventive and pharmaceutical significance of natural products. Schisandrin is mainly obtained from Schisandra chinensis. Schisandrin has been shown to be effective against different cancers because of its ability to inhibit/prevent cancer via modulation of different cell signaling pathways. Importantly, regulation of non-coding RNAs by schisandrin is an exciting area of research that still needs detailed and comprehensive research. However, we still have unresolved questions about pharmacological properties of schisandrin mainly in context of its regulatory role in TGF/SMAD, SHH/GLI, NOTCH and Hippo pathways.

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Current Perspective on the Natural Compounds and Drug Delivery Techniques in Glioblastoma Multiforme

Cited by 48 publications

References 220 publications

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"

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