Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction

Sulfated Polysaccharide-Based Nanocarrier Drives Microenvironment-Mediated Cerebral Neurovascular Remodeling for Ischemic Stroke Treatment

“…The microglia, a cohort of immune cells that inhabit the central nervous system (CNS), primarily assume the pivotal roles of safeguarding the host, modulating inflammation, and facilitating functional recovery after ischemic stroke . After blood reperfusion, the rapid generation of ROS triggers microvascular dysfunction and microthrombus formation, subsequently leading to the clustering and activation of microglia around injured brain capillaries through the interaction between fibrin and microglial integrin receptors. , The activation of microglia serves as the initial response to a stroke event, displaying remarkable heterogeneity and possessing the ability to adapt to their surrounding microenvironment, thereby secreting cytokines that effectively regulate angiogenesis, myelin regeneration, and neuronal remodeling .…”