Current postbiotics in the cosmetic market—an update and development opportunities

Duarte, Marco; Oliveira, Ana; Oliveira, Carla Cristina Marques de; Pintado, Manuela; Amaro, A. L.; Madureira, Ana Raquel

doi:10.1007/s00253-022-12116-5

Cited by 34 publications

(32 citation statements)

References 56 publications

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“…Most metabolites with a physiological activity are produced by LAB and show various health benefit activities, such as antioxidant, anti-inflammatory, immunomodulatory, and anti-microbial activities [ 19 , 20 , 21 , 23 , 25 ]. Additionally, compared to probiotics, postbiotics show similar beneficial effects and higher stability and safety, meaning postbiotics are highly sustainable ingredients in cosmetic products [ 17 ]. In particular, previous studies have clinically proven that postbiotics can improve skin health.…”

Section: Discussionmentioning

confidence: 99%

“…Topical application of an anti-acne lotion containing a fermented lysate produced by Lactiplantibacillus plantarum has been shown to improve moisturization and regulate skin pH, with positive results in the treatment of acne [ 95 ]. Additionally, various products using postbiotics as ingredients exist in the cosmetic market [ 17 ]. Therefore, fermented maca root extract is highly likely to be applied as a cosmetic ingredient, and additional safety and clinical-efficacy tests are required.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, heat-killed Lactococcus chungagnensis CAU 1447 has shown beneficial effects on wound healing by inducing the expression of wound-healing-promoting cytokines, chemokines, and growth factors [ 15 , 16 ]. This suggests that the topical application of postbiotics has beneficial effects on the skin; consequently, there is a growing market trend for the inclusion of postbiotics in cosmetic ingredients and/or products [ 17 ]. In fact, several postbiotics are already widely used in cosmetics [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

et al. 2023

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Maca is a well-known biennial herb with various physiological properties, such as antioxidant activity and immune response regulation. In this study, the antioxidant, anti-inflammatory, and anti-melanogenic effects of fermented maca root extracts were investigated. The fermentation was carried out using Lactobacillus strains, such as Lactiplantibacillus plantarum subsp. plantarum, Lacticaseibacillus rhamnosus, Lacticaseibacillus casei, and Lactobacillus gasseri. In RAW 264.7 cells, the non-fermented maca root extracts increased the secretion of nitric oxide (NO), an inflammatory mediator, in a dose-dependent manner. In contrast, the fermented extracts showed considerably lower NO secretion than the non-fermented extracts at concentrations of 5% and 10%. This indicates the effective anti-inflammatory effects of fermented maca. The fermented maca root extracts also inhibited tyrosinase activity, melanin synthesis, and melanogenesis by suppressing MITF-related mechanisms. These results show that fermented maca root extracts exhibit higher anti-inflammatory and anti-melanogenesis effects than non-fermented maca root extracts. Thus, maca root extracts fermented using Lactobacillus strains have the potential to be used as an effective cosmeceutical raw material.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

et al. 2023

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“…In addition, these compounds have shown antimicrobial effect over Pseudomonas aeruginosa, an opportunistic pathogen and cosmetic contaminant, and Cutibacterium acnes, the acne-causing bacteria and in the treatment of dermatological diseases (e.g., Alopecia areata). [6][7][8][9][10][11][12][13][14][15] A recent review by our research group 16 describes what is currently known about these compounds, the benefits of using them, the main postbiotics products available in the market and players, the production key trends and available production methods.…”

mentioning

confidence: 99%

“…[17][18][19][20] Furthermore, most of these compounds are usually derived from lactic acid bacteria, Lactobacillus genera and/or yeast, especially Saccharomyces cerevisiae, and as a substrate, lignocellulosic material can be used as a carbon/sugar and phenolic compounds (great antioxidant activity) source. 16 The main advantages identified for the use of postbiotics are related to their higher specificity of action on resident microbiota as of interaction with cells of the host compared to probiotics. Besides that, also relatively to probiotics, postbiotics have longer shelf life and greater safety and do not require viability in the topical formulation, 9,21 which turns them into an innovative approach within the cosmetic ingredients market.…”

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confidence: 99%

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Duarte

Carvalho

et al. 2023

BioFactors

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Postbiotics are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” They can be produced by fermentation, using culture media with glucose (carbon source), and lactic acid bacteria of the genus Lactobacillus, and/or yeast, mainly Saccharomyces cerevisiae as fermentative microorganisms. Postbiotics comprise different metabolites, and have important biological properties (antioxidant, anti‐inflammatory, etc.), thus their cosmetic application should be considered. During this work, the postbiotics production was carried out by fermentation with sugarcane straw, as a source of carbon and phenolic compounds, and as a sustainable process to obtain bioactive extracts. For the production of postbiotics, a saccharification process was carried out with cellulase at 55°C for 24 h. Fermentation was performed sequentially after saccharification at 30°C, for 72 h, using S. cerevisiae. The cells‐free extract was characterized regarding its composition, antioxidant activity, and skincare potential. Its use was safe at concentrations below ~20 mg mL−1 (extract's dry weight in deionized water) for keratinocytes and ~ 7.5 mg mL−1 for fibroblasts. It showed antioxidant activity, with ABTS IC50 of 1.88 mg mL−1, and inhibited elastase and tyrosinase activities by 83.4% and 42.4%, respectively, at the maximum concentration tested (20 mg mL−1). In addition, it promoted the production of cytokeratin 14, and demonstrated anti‐inflammatory activity at a concentration of 10 mg mL−1. In the skin microbiota of human volunteers, the extract inhibited Cutibacterium acnes and the Malassezia genus. Shortly, postbiotics were successfully produced using sugarcane straw, and showed bioactive properties that potentiate their use in cosmetic/skincare products.

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Applications of Synbiotics as Cosmeceuticals

Yadav,

Sapra

2024

Synbiotics in Human Health: Biology to Drug Delivery

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Current postbiotics in the cosmetic market—an update and development opportunities

Cited by 34 publications

References 56 publications

Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Applications of Synbiotics as Cosmeceuticals

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