Current Practice in FFP Preparation and Use in Greece. A National Survey

Argyrou, Aspasia; Valsami, Serena; Pouliakis, Abraham; Gavalaki, Maria; Aggelidis, A; Voulgaridou, Virginia; Pliatsika, V; Adraktas, T.; Papachronis, Andreas; Alepi, C; Giannopoulou, Vassiliki; Siourounis, Panagiotis; Tsagia, S; Martinis, George; Kontekaki, Eftychia; Zervou, Eleftheria; Koliofotis, S; Kyriakou, Elias; Mougiou, Athina; Lempousi, D; Chairopoulou, A; Tsakania, A; Baka, Maria; Apostolidou, Ioanna; Moschandreou, Dimitra; Livada, Anastasia; Politou, Marianna; Roussinou, F; Pappa, C; Koika, V; Vgontza, Niki; Gafou, A; Dendrinou, I; Sakellaridi, F; Labrianou, C; Alexandropoulou, Zafeiria; Sochali, V; Malekas, Konstantinos; Skordilaki, A; Kakava, G; Lebesopoulos, K; Stamoulis, Konstantinos; Grouzi, Elisavet

doi:10.4274/tjh.galenos.2020.2020.0241

Cited by 40 publications

(70 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ferroptosis inhibition exhibits cytoprotection and alleviates inflammation in NASH (Tsurusaki et al, 2019). Iron accumulation in HSCs facilitates the progression of NASH to fibrosis via inducing fibrogenic activation, which is dependent on ROS (Gao et al, 2022b). As mentioned previously, targeting ferroptosis has significant potential for the prevention and treatment of NASH.…”

Section: Targeted Therapeutic Strategy Of Ferroptosis In Nashmentioning

confidence: 89%

“…Aberrant iron distribution leads to hepatic metabolic diseases. Hepatocytes have been confirmed to be iron deficient, and hepatic stellate cells have been demonstrated to be overloaded with iron in NAFLD (Gao et al, 2022b). Programmed cell death triggered by ROS accumulation in hepatocytes is a possible cause of liver injury and inflammation in NASH.…”

Section: Targeted Therapeutic Strategy Of Ferroptosis In Nashmentioning

confidence: 99%

See 1 more Smart Citation

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

Yang

Wang

2023

Front. Pharmacol.

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) has been identified as the most common chronic liver disease worldwide, with a growing incidence. NAFLD is considered the hepatic manifestation of a metabolic syndrome that emerges from multiple factors (e.g., oxidative stress, metabolic disorders, endoplasmic reticulum stress, cell death, and inflammation). Non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, has been reported to be a leading cause of cirrhosis and hepatic carcinoma, and it is progressing rapidly. Since there is no approved pharmacotherapy for NASH, a considerable number of therapeutic targets have emerged with the deepening of the research on NASH pathogenesis. In this study, the therapeutic potential and properties of regulating metabolism, the gut microbiome, antioxidant, microRNA, inhibiting apoptosis, targeting ferroptosis, and stem cell-based therapy in NASH are reviewed and evaluated. Since the single-drug treatment of NASH is affected by individual heterogeneous responses and side effects, it is imperative to precisely carry out targeted therapy with low toxicity. Lastly, targeted therapeutic agent delivery based on exosomes is proposed in this study, such that drugs with different mechanisms can be incorporated to generate high-efficiency and low-toxicity individualized medicine.

show abstract

Section: Targeted Therapeutic Strategy Of Ferroptosis In Nashmentioning

confidence: 89%

Section: Targeted Therapeutic Strategy Of Ferroptosis In Nashmentioning

confidence: 99%

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

Yang

Wang

2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The duration of the more quiescent phase between prompt overturning convection and vigorous turbulence depends upon the seed perturbations in the progenitor core [15], of which the duration of this phase is diagnostic. Relevant for the GW signature is the equation of state (EOS) [59,[64][65][66], the rate of neutronization and neutrino cooling of the core [56,67], and the stellar core's initial angular momentum and mass density distributions. Measurable GW signatures of rotation require particular progenitors that rotate fast, while all other phases/phenomena are expected to be operative in any core-collapse context, except matter memory, which requires an asymmetric explosion.…”

mentioning

confidence: 99%

The Gravitational-Wave Signature of Core-Collapse Supernovae

Vartanyan¹,

Burrows²,

Coleman³

et al. 2023

Preprint

View full text Add to dashboard Cite

We calculate the gravitational-wave (GW) signatures of detailed 3D core-collapse supernova simulations spanning a range of massive stars. Most of the simulations are carried out to times late enough to capture more than 95% of the total GW emission. We find that the f/g-mode and f-mode of proto-neutron star oscillations carry away most of the GW power. The f-mode frequency inexorably rises as the proto-neutron star (PNS) core shrinks. We demonstrate that the GW emission is excited mostly by accretion plumes onto the PNS that energize modal oscillations and also highfrequency ("haze") emission correlated with the phase of violent accretion. The duration of the major phase of emission varies with exploding progenitor and there is a strong correlation between the total GW energy radiated and the compactness of the progenitor. Moreover, the total GW emissions vary by as much as three orders of magnitude from star to star. For black-hole formation, the GW signal tapers off slowly and does not manifest the haze seen for the exploding models. For such failed models, we also witness the emergence of a spiral shock motion that modulates the GW emission at a frequency near ∼100 Hertz that slowly increases as the stalled shock sinks. We find significant angular anisotropy of both the high-and low-frequency (memory) GW emissions, though the latter have very little power.

show abstract

“…The M2M-100 model (Fan et al, 2020) is a many-to-many multilingual translation system that is pre-trained on a large-scale parallel dataset for 100 languages and 100×99 translation directions. This dataset is automatically constructed with a novel data mining method based on language similarities and back-translation.…”

Section: Many-to-many Multilingual Mtmentioning

confidence: 99%

“…There has been enormous progress on scaling up neural machine translation (NMT) in recent years, resulting in 'massively multilingual' models that are capable of translating across many languages (Bapna et al, 2022). Most successful applications rely on sequence-to-sequence pre-training that ( 1) leverages web-scale monolingual data with a masking objective to build a multilingual backbone (parent) model (Liu et al, 2020;Song et al, 2019), or (2) directly targets a many-to-many NMT system by mining parallel corpora (Fan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Multilingual Learning and Adaptation for Neural Language Models

Üstün¹

View full text Add to dashboard Cite

This thesis represents more than just an academic achievement. It marks a new chapter in my life, one that has been filled with lots of fun, fulfillment, and rewards that will endure for a lifetime. I would like to sincerely thank everyone who has supported me along the way.First and foremost, I thank my supervisors: Gertjan, Gosse, and Arianna.Gertjan, you were a constant source of support that I needed many times. As my supervisor, you always made me feel secure and confident, not only in my academic pursuits but also as a person. Your guidance on my research direction has played a pivotal role in this thesis. I will also always remember our attempt at a 40 km walk, even though I was not unable to finish it.Gosse, in addition to your continuous mentorship for my research and this thesis, your calm attitude and patience as a supervisor, were perfect examples for me to follow, especially as an ambitious and sometimes impatient student, that helped me become a better researcher. I also genuinely enjoyed our lunchtime chats, particularly about cycling, which made me excited to watch the Tour de France at the end of 4 years.Arianna, I'm very glad that I asked you to be my supervisor when you joined the department. Your knowledge and guidance in my research interests, your attention to precise details and pursuit for "excellence" have deeply influenced this thesis and my perspective on research. I also never imagined having a supervisor with whom I can speak Turkish which is an unexpected delight, especially with your kids. I believe we made a great team, and working together was a truly enjoyable experience. Once again, I thank my supervisors.Throughout my PhD, I had the opportunity to collaborate with a group of exceptional individuals. I would like to thank Asa Cooper Stickland, Alexandre Berard, Barbara Plank, Matthias Gallé, Rob van der Goot, Laurent Besacier, and Sebastian Ruder for their invaluable contribution to my research.I would also like to thank the members of my reading committee, Joakim Nivre, Jörg Tiedemann, and Jack Hoeksema, for reading my thesis and providing me with useful feedback which helped to improve this thesis.

show abstract

Current Practice in FFP Preparation and Use in Greece. A National Survey

Cited by 40 publications

References 6 publications

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

The Gravitational-Wave Signature of Core-Collapse Supernovae

Multilingual Learning and Adaptation for Neural Language Models

Contact Info

Product

Resources

About