Current Practice of Genetics Research of Psychiatric Disorders

Abstract

After a brief review of major factors that influence results of genetic studies, we summarize key considerations in designing genetic studies of psychiatric disorders. A sufficient sample size is needed, along with an appropriate threshold for statistical significance. Rigorous quality assessment, controls of covariates and population structure, and replication of results in a second data set are critical to avoid spurious findings. Data sharing should be promoted to enable powerful big data analyses. Gradually, functional studies will be incorporated into genetic studies to improve the quality of genetic studies and biological interpretation of statistical associations.