Current requirements for polymeric biomaterials in otolaryngology

Sternberg, Katrin

doi:10.3205/cto000063

Cited by 8 publications

(8 citation statements)

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“…One of the methods of its application is drug depot accommodation in the silicon carrier of the electrode [ 35 ] ( Figure 3 ). This approach has a more continuous and longer profile of drug release, which is more effective than other methods of dexamethasone application [ 2 , 36 ]. It is desirable to minimize the space between electrodes and auditory neuronal dendrites.…”

Section: Biomaterials Used In Otorhinolaryngologymentioning

confidence: 99%

“…The first application of biomaterial in history is most likely a case that was reported a few centuries after the Common Era of ancient medicine for wound closure. Romans have described urologic catheters, and Aztecs used gold dental fillings [ 2 ]. Nowadays, technological progress allows the development of implants that are based on innovative biomaterials.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties

Spałek

Ociepa

Deptuła

et al. 2022

IJMS

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For decades, biomaterials have been commonly used in medicine for the replacement of human body tissue, precise drug-delivery systems, or as parts of medical devices that are essential for some treatment methods. Due to rapid progress in the field of new materials, updates on the state of knowledge about biomaterials are frequently needed. This article describes the clinical application of different types of biomaterials in the field of otorhinolaryngology, i.e., head and neck surgery, focusing on their antimicrobial properties. The variety of their applications includes cochlear implants, middle ear prostheses, voice prostheses, materials for osteosynthesis, and nasal packing after nasal/paranasal sinuses surgery. Ceramics, such as as hydroxyapatite, zirconia, or metals and metal alloys, still have applications in the head and neck region. Tissue engineering scaffolds and drug-eluting materials, such as polymers and polymer-based composites, are becoming more common. The restoration of life tissue and the ability to prevent microbial colonization should be taken into consideration when designing the materials to be used for implant production. The authors of this paper have reviewed publications available in PubMed from the last five years about the recent progress in this topic but also establish the state of knowledge of the most common application of biomaterials over the last few decades.

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Section: Biomaterials Used In Otorhinolaryngologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties

Spałek

Ociepa

Deptuła

et al. 2022

IJMS

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“…2,8 To tackle the issues, biomaterials have been extensively used as a scaffold of cells and the carrier of drug delivery system for bioactive molecules to effectively enhance the cell activity. 9 Needless to say the biocompatibility of biomaterials, it is therapeutically important to consider the responses of biomaterials to inflammation which invariably takes place in use.…”

Section: Introductionmentioning

confidence: 99%

An artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1

2023

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A silk elastin-like protein (SELP) is an artificial compound with silk fibroin-like and elastin-like tandem repeats. The objective of this study is to evaluate the influence of SELP on the polarization of human monocytoma cell line (THP-1)-derived macrophages. When the macrophages of inflammation-type (M1) were cultured with different concentrations of SELP solution, the secretion of a pro-inflammatory cytokine, tumor necrotizing factor (TNF) -α was significantly suppressed at the higher concentrations. In addition, the secretion of an anti-inflammation cytokine, interleukin (IL)-10, was significantly enhanced from the macrophage of M0-, M1-, and M2-types. By the incubation with soluble SELP, the morphology of M2-type macrophages changed to be of an extended shape. Following incubation with the sponge of SELP, M0-type macrophages secreted IL-10 with time. It is concluded that the SELP itself in solution has an ability to induce the anti-inflammation of M2-type macrophages.

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“…It has been demonstrated that when combined with growth factors, biomaterials promote cell-based tissue regeneration. − There are several issues to be improved to realize the tissue regeneration therapy. It is well recognized that cells transplanted have a low survival rate, and their therapeutic efficacy is not always as high as expected. , When simply injected, bioactive molecules do not always activate the ability of cells for tissue regeneration. , In several trials to tackle the issues, biomaterials have been extensively used as a scaffold of cells and the carrier of a drug delivery system for bioactive molecules to effectively enhance the cell activity . In addition to the biocompatibility of biomaterials, it is important to consider the responses of biomaterials to inflammation which invariably takes place in use.…”

Section: Introductionmentioning

confidence: 99%

“…2,8 In several trials to tackle the issues, biomaterials have been extensively used as a scaffold of cells and the carrier of a drug delivery system for bioactive molecules to effectively enhance the cell activity. 9 In addition to the biocompatibility of biomaterials, it is important to consider the responses of biomaterials to inflammation which invariably takes place in use.…”

Section: ■ Introductionmentioning

confidence: 99%

An Artificial Silk Elastin-Like Protein Modifies the Polarization of Macrophages

Unzai

Washisaka

Tabata

2022

ACS Appl. Bio Mater.

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A silk elastin-like protein (SELP) is an artificial compound with silk fibroin-like and elastin-like tandem repeats. The objective of this study is to evaluate the influence of SELP on the polarization of mouse bone marrow-derived macrophages. When the macrophages of inflammation-type (M1) were cultured with different concentrations of SELP solution, the secretion of a pro-inflammatory cytokine, tumor necrotizing factor (TNF)-α, was significantly suppressed at the higher concentrations. In addition, the secretion of an anti-inflammation cytokine, interleukin (IL)-10, was significantly enhanced from the macrophage of an original type (M0). By the incubation with soluble SELP, the morphology of M0-and M1-type macrophages changed to be of a round shape with a large size. Following incubation with the sponge of SELP, the M0-type macrophages secreted IL-10 with time. When injected into an air pouch of mice subcutis which had been prepared by the injection of air, the SELP sponge and 5 wt % of SELP solution induced IL-10 secretion to a significantly high extent compared with the saline injection. Cells isolated from the air pouch 24 h after the injection were stained by the CD206 of a M2 marker. It is concluded that the SELP itself in solution has an ability to induce the anti-inflammation M2-type macrophages.

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Current requirements for polymeric biomaterials in otolaryngology

Cited by 8 publications

References 62 publications

Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties

Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties

An artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1

An Artificial Silk Elastin-Like Protein Modifies the Polarization of Macrophages

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