Current research into the association between DNA copy number variation (CNV) and obesity

Shorter, Emily

doi:10.1093/biohorizons/hzx014

Cited by 1 publication

(2 citation statements)

References 41 publications

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“…9,10 The genetic connection between AMY1 CNV and obesity showed that low AMY1 copy number significantly associated with high BMI. 4,5,[11][12][13] Recently from our lab, we showed the inverse association of AMY1 copy number and the obesity measurement in children. 13 Falchi et al first reported the association of AMY1 CNV and the high risk of obesity in a longitudinal study.…”

Section: Introductionmentioning

confidence: 93%

“…3 Even though obesity is known as an imbalance between energy expenditure and food intake, there are several genetic and non-genetics factors such as environmental, behavioral factors involved in obesity. 4,5 Within an individual family, there can be a 40 to 70% inter-individual variability in body mass index (BMI), as a result of accredited to the involvement of genetic factors. 6 In recent years, Genome-Wide Association Studies (GWAS) is a useful approach to detect single nucleotide polymorphisms (SNPs) and copy number variants (CNV) associated with increased BMI and obesity.…”

Section: Introductionmentioning

confidence: 99%

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<p>Salivary Amylase Gene Copy Number Is Associated with the Obesity and Inflammatory Markers in Children</p>

Selvaraju¹,

Venkatapoorna²,

Babu³

et al. 2020

DMSO

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Background: We have recently shown that the copy number of salivary amylase (AMY1) gene was significantly decreased, and the obesity-related salivary biomarkers resistin, MCP-1, TNF-α, IL-6, and CRP were significantly increased in overweight/obese children compared to normal weight. This study aimed to evaluate the association of AMY1 copy number variant (CNV) with obesity and inflammatory markers. Seventy-six participants aged between 6 and 10 years have participated, and the saliva samples were collected along with the anthropometric measurements. Methods: AMY1 copy number was analyzed by 3D digital PCR, and obesity-related biomarkers were performed with a Bioplex multiplex analyzer. Results: The mean AMY1 copy number was higher in normal weight (7.90 ± 0.38) compared to the overweight/obese group (6.20 ± 0.29). The association of AMY1 CNV with obesity and inflammatory markers showed significant negative correlation [CRP, β = −0.238 (p < 0.05); resistin, β = −0.25 (p < 0.05); MCP-1, β = −0.304 (p < 0.01)] except for complement factor D, TNF α and IL-6. The anti-inflammatory cytokine, IL-10 reported a positive correlation with AMY1 copy number with a β = 0.268 (p < 0.05). The multivariable model adjusted with age and gender depicted a similar correlation with obesity markers. Conclusion: Our results report that AMY1 CNV is associated with obesity and inflammatory biomarkers in children's saliva sample.

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