Current research on head and neck cancer-associated long noncoding RNAs

Song, Wei; Sun, Yimin; Lin, Jie; Xiao-qin, BI

doi:10.18632/oncotarget.22608

Cited by 15 publications

(13 citation statements)

References 173 publications

(315 reference statements)

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“…Among other things, functional non-coding RNAs are known to regulate the expression of protein-coding genes, and are involved in the maintenance of genome integrity [38,39]. Of relevance to this study, several long non-coding and small nucleolar RNAs have been found to be deregulated in head and neck squamous cell carcinoma [40,41], a cancer type strongly associated with tobacco smoking [42]. It has been suggested that these regulatory non-coding RNAs may drive malignant transformation by influencing cancer cell viability and motility [40,41].…”

Section: Discussionmentioning

confidence: 99%

Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users

Tommasi

Caliri

Caceres

et al. 2019

IJMS

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We have investigated the regulation of genes and associated molecular pathways, genome-wide, in oral cells of electronic cigarette (e-cigs) users and cigarette smokers as compared to non-smokers. Interrogation of the oral transcriptome by RNA-sequencing (RNA-seq) analysis showed significant number of aberrantly expressed transcripts in both e-cig users (vapers) and smokers relative to non-smokers; however, smokers had ~50% more differentially expressed transcripts than vapers (1726 versus 1152). Whereas the deregulated transcripts in smokers were predominately from protein-coding genes (79% versus 53% in vapers), nearly 28% of the aberrantly expressed transcripts in vapers (versus 8% in smokers) belonged to regulatory non-coding RNAs, including long intergenic non-coding, antisense, small nucleolar and misc RNA (P < 0.0001). Molecular pathway and functional network analyses revealed that “cancer” was the top disease associated with the deregulated genes in both e-cig users and smokers (~62% versus 79%). Examination of the canonical pathways and networks modulated in either e-cig users or smokers identified the “Wnt/Ca+ pathway” in vapers and the “integrin signaling pathway” in smokers as the most affected pathways. Amongst the overlapping functional pathways impacted in both e-cig users and smokers, the “Rho family GTPases signaling pathway” was the top disrupted pathway, although the number of affected targets was three times higher in smokers than vapers. In conclusion, we observed deregulation of critically important genes and associated molecular pathways in the oral epithelium of vapers that bears both resemblances and differences with that of smokers. Our findings have significant implications for public health and tobacco regulatory science.

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Section: Discussionmentioning

confidence: 99%

Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users

Tommasi

Caliri

Caceres

et al. 2019

IJMS

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“…The use of new technologies to investigate tumor behavior and microenvironment is of great interest in this era of precision medicine. Several studies unraveled the role of molecular biomarkers for the diagnostic and therapeutic process in patients with OSCC [24–26]. The application of “biologic endoscopy” to intraoperative surgical procedures represents another step forward towards the realization of the potentials of customized surgery [9, 10, 27, 28].…”

Section: Discussionmentioning

confidence: 99%

A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: results from a prospective single-institution series

et al. 2019

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Background The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and narrow band imaging (NBI). Methods Sixteen OSCC patients eligible for surgery were prospectively enrolled. For each patient, 2 to 6 bioptic samples of MM and NBI margins were obtained and histologically analyzed for the presence of dysplasia and lymphocytes. Microvessel density was investigated by CD34 immunohistochemistry. Results Taken together, 104 specimens were analyzed, including 15% tumors, 33% MM, 33% NBI margins, and 19% MM-NBI overlapping margins. The NBI margins were closer to the lesion in 50% cases, while the same number of MM were more conservative than NBI, irrespective of the tumor site. The rate of histologically positive margins was similar among the two methods, akin to the microvessel density. Conclusions MM assessment should be integrated but not replaced with the NBI technology to allow for more conservative surgery.

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“…Next-generation sequencing has identified tens of thousands of lncRNAs from single-cell eukaryotes to humans [8]. LncRNAs are expressed in a tissue and cell-type specific manner, making them potential cancer biomarkers [4] and many SCCHN-related lncRNAs have been reported based on differential expression at a given significance level [9,10], even if the function of these disease-associated lncRNAs is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck

Wang

Boldrup

et al. 2019

Cancers

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A growing number of long non-coding RNAs (lncRNAs) have been linked to squamous cell carcinoma of the head and neck (SCCHN). A subclass of lncRNAs, termed enhancer RNAs (eRNAs), are derived from enhancer regions and could contribute to enhancer function. In this study, we developed an integrated data analysis approach to identify key eRNAs in SCCHN. Tissue-specific enhancer-derived RNAs and their regulated genes previously predicted using the computational pipeline PreSTIGE, were considered as putative eRNA-target pairs. The interactive web servers, TANRIC (the Atlas of Noncoding RNAs in Cancer) and cBioPortal, were used to explore the RNA levels and clinical data from the Cancer Genome Atlas (TCGA) project. Requiring that key eRNAs should show significant associations with overall survival (Kaplan–Meier log-rank test, p < 0.05) and the predicted target (correlation coefficient r > 0.4, p < 0.001), we identified five key eRNA candidates. The most significant survival-associated eRNA was AP001056.1 with ICOSLG encoding an immune checkpoint protein as its regulated target. Another 1640 genes also showed significant correlation with AP001056.1 (r > 0.4, p < 0.001), with the “immune system process” being the most significantly enriched biological process (adjusted p < 0.001). Our results suggest that AP001056.1 is a key immune-related eRNA in SCCHN with a positive impact on clinical outcome.

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Current research on head and neck cancer-associated long noncoding RNAs

Cited by 15 publications

References 173 publications

Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users

Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users

A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: results from a prospective single-institution series

AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck

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