Current Role of Carnoy's Solution in Treating Keratocystic Odontogenic Tumors

Endoscopic resection of maxillary sinus keratocystic odontogenic tumors

“…Historically, open approaches have utilized Carnoy's solution, which has been shown to be successful in ablating remnant epithelia. Carnoy's solution was originally compounded with 100% ethanol, chloroform, and glacial acetic acid, with added ferric chloride, and it was used as a fixative in histology . However, a U.S. Food and Drug Administration ban on pharmacies compounding with chloroform was established in 1992 because the substance was known to be carcinogenic.…”

Management of Odontogenic Cysts by Endonasal Endoscopic Techniques: A Systematic Review and Case Series

“…Adjunctive use of the Carnoy or the modified Carnoy solution has been applied to remnant epithelia in the treatment KCOT in both open and endoscopic techniques. 3,12,33 The Carnoy solution consists of 100% ethanol, chloroform, glacial acetic acid, and ferric chloride. 33 Compounding with chloroform, however, was banned in 1992 by the U.S. Food and Drug Administration due to carcinogenic effects, and, therefore, modified solutions without chloroform have been used.…”

“…3,12,33 The Carnoy solution consists of 100% ethanol, chloroform, glacial acetic acid, and ferric chloride. 33 Compounding with chloroform, however, was banned in 1992 by the U.S. Food and Drug Administration due to carcinogenic effects, and, therefore, modified solutions without chloroform have been used. 12,33 These modified solutions remain flammable and corrosive to instrumentation.…”

“…33 Compounding with chloroform, however, was banned in 1992 by the U.S. Food and Drug Administration due to carcinogenic effects, and, therefore, modified solutions without chloroform have been used. 12,33 These modified solutions remain flammable and corrosive to instrumentation. 12 Adjunctive chemical treatment of remnant epithelia was not used in most of the reports included in this systematic review and is not used in our endoscopic management of these lesions.…”

Keratocystic Odontogenic Tumours: Etiology, Pathogenesis and Treatment Revisited

“…One factor that is yet to be studied is the effect of a ''modified'' version of the solution without chloroform, on the penetrative capability and effect of the solution [41].…”