Current standards for diagnosis and treatment of syphilis: selection of some practical issues, based on the European (IUSTI) and U.S. (CDC) guidelines

Pastuszczak, Maciej; Wojas‐Pelc, Anna

doi:10.5114/pdia.2013.37029

Cited by 41 publications

(43 citation statements)

References 19 publications

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“…Differences between our outcomes and those in previous studies may be due to an improved immune-status of HIV-positive patients because of highly active antiretroviral therapy (HAART). 26,27 In line with this, current IUSTI guidelines 1,12,13 state that HIV coinfected syphilitic patients should be treated as immunocompetent patients, except for those who have CD4þ cell counts of 350/lL.…”

Section: Hivmentioning

confidence: 99%

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Clinical Manifestations and Outcome of Syphilitic Uveitis

Bollemeijer¹,

Wieringa

Missotten

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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RESULTS. Mean age was 47 years (range, 27-73 years), 82.4% were male. HIV positivity was found in 28 (35.9%) patients; 13 were newly diagnosed. Most patients had pan (45.9%) or posterior (31.8%) uveitis. On average, logMAR visual acuity (VA) improved significantly from 0.55 at the start of syphilis treatment to 0.34 at 1 month and to 0.27 at 6 months follow-up. Most patients (86.7%) reached disease remission. No differences in efficacy between the various treatment regimens were found. A high logMAR VA at the start of syphilis treatment and a treatment delay of more than 12 weeks were prognostic for a high logMAR VA at 6 months follow-up. Chronicity was not related to any form of treatment, HIV status, or Venereal Disease Research Laboratory test outcome. CONCLUSIONS.In this large cohort of 85 patients with syphilitic uveitis, visual outcomes were favorable in the majority of cases. Visual outcome was dependent on VA at the start of syphilis treatment and treatment delay.

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Section: Hivmentioning

confidence: 99%

“…1,12,13 In special situations (pregnancy, allergy, or refusal of intravenous treatment), oral or intramuscular treatment can be considered. Improvement in VA at 1 and 6 months was seen in all groups of patients independent of the route of administration of antibiotics.…”

Section: Antibiotic Treatmentmentioning

confidence: 99%

Clinical Manifestations and Outcome of Syphilitic Uveitis

Bollemeijer¹,

Wieringa

Missotten

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…115 Doxycycline, tetracycline, or erythromycin may be used for 116 patients who are allergic to penicillin. 4 127 Various types of cytokine secretion change during the different 128 stages of syphilis, and there has been a lot of research into cytokine 129 secretion in syphilis. In one study, it was found that the cells of 130 syphilitic patients were already able to produce interleukin (IL)-2, 131 interferon, tumor necrosis factor, and IL-10, and weakly IL-6, in 132 primary seronegative syphilis.…”

mentioning

confidence: 99%

Cervical syphilitic lesions mimicking cervical cancer: a rare case report

Zhu

Zhang

Jing

et al. 2015

International Journal of Infectious Diseases

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A woman presented to the hospital due to postcoital vaginal bleeding. The patient was initially diagnosed with cervical carcinoma by clinicians at a local hospital. However, a biopsy of the cervical lesions revealed chronic inflammation and erosion of the cervical mucosa, and the rapid plasma reagin ratio titer was 1:256. The patient was eventually diagnosed with syphilitic cervicitis and treated with minocycline 0.1g twice a day. The patient was cured with this treatment.

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“…20 Overall, the nontreponemal tests have a sensitivity of 86% in primary syphilis and 100% in secondary syphilis. At least 1 treponemal antigen test and 1 nontreponemal antigen test area sufficient to confirm syphilis.…”

Section: Diagnosis Of Syphilismentioning

confidence: 99%

Sexually Transmitted Diseases

Bechtel¹,

Trout

2015

Clinical Obstetrics &Amp; Gynecology

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Sexually transmitted diseases (STDs) continue to be a global epidemic with significant risk of morbidity/mortality for the fetus. STDs with prominent cutaneous findings including condylomata acuminata, genital herpes infections, and syphilis are reviewed. Important clinical cutaneous findings help aid early diagnosis and facilitate treatment. Condylomata acuminata have the potential of causing cervical cancer, anogenital cancer, and oropharyngeal cancer. Significant advances have been made in human papilloma virus vaccinations and treatment. Genital herpes infection can produce significant physical and emotional distress to the patient and significant potential harm to the fetus. Early clinical recognition of STDs and their appropriate management is critical.

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Current standards for diagnosis and treatment of syphilis: selection of some practical issues, based on the European (IUSTI) and U.S. (CDC) guidelines

Cited by 41 publications

References 19 publications

Clinical Manifestations and Outcome of Syphilitic Uveitis

Clinical Manifestations and Outcome of Syphilitic Uveitis

Cervical syphilitic lesions mimicking cervical cancer: a rare case report

Sexually Transmitted Diseases

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