Current State and Future Perspectives on Personalized Metabolomics

Abstract

Metabolomics is one of the most promising ‘omics’ sciences for the implementation in medicine by developing new diagnostic tests and optimizing drug therapy. Since in metabolomics, the end products of the biochemical processes in an organism are studied, which are under the influence of both genetic and environmental factors, the metabolomics analysis can detect any changes associated with both lifestyle and pathological processes. Almost every case-controlled metabolomics study shows a high diagnostic accuracy. Taking into account that metabolomics processes are already described for most nosologies, there are prerequisites that a high-speed and comprehensive metabolite analysis will replace, in near future, the narrow range of chemical analyses used today, by the medical community. However, despite the promising perspectives of personalized metabolomics, there are currently no FDA-approved metabolomics tests. The well-known problem of complexity of personalized metabolomics data analysis and their interpretation for the end-users, in addition to a traditional need for analytical methods to address the quality control, standardization, and data treatment are reported in the review. Possible ways to solve the problems and change the situation with the introduction of metabolomics tests into clinical practice, are also discussed.

Metabolomic Analysis of Respiratory Epithelial Lining Fluid in Patients with Chronic Obstructive Pulmonary Disease—A Systematic Review

“…In order to investigate the usefulness of metabolites as biomarkers or predictors, studies with metabolome measurements over time are urgently needed, taking into account changes in clinical parameters, including clinical symptoms. Figure 3 outlines future research directions in the field of metabolomics in COPD and its phenotypes [ 37 ].…”

Holothuria leucospilota polysaccharides (HLP) ameliorate colitis rats via regulation of the metabolic profiling and TLR4/NLRP3 signaling pathways

“…Metabolites are the bridge between genotype and phenotype. Changes in levels of metabolites effectively reveal biochemical and molecular mechanisms (Trifonova et al., 2023). UPLC–Q‐TOF/MS is widely used in metabolomics research because of its high sensitivity and precision.…”

Metabolomics and Cardiovascular Risk in Patients with Heart Failure: A Systematic Review and Meta-Analysis

“…However, despite such huge data sets collected to date and such promising perspectives of personalized metabolomics, there are yet no clinical metabolomics applications [ 70 ]. One of the main problems discussed in the literature and corroborated in this study is the lack of standardization across all stages of research.…”

“…One of the main problems discussed in the literature and corroborated in this study is the lack of standardization across all stages of research. Only through the standardization of analytical strategies, data statistical analysis and reporting, findings may be compared and combined [ 70 ]. The Metabolomics Standards Initiative (MSI) [ 71 ] and the Framework Programme 7 EU Initiative ‘coordination of standards in metabolomics’ (COSMOS) [ 72 ] have already pinpointed the importance of standardization in all stages of the metabolomic framework.…”