2023
DOI: 10.1016/j.transproceed.2023.03.060
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Current Status of Genetically Engineered Pig to Monkey Kidney Xenotransplantation in Korea

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Cited by 2 publications
(2 citation statements)
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“…Despite the challenges, unwavering efforts are in progress to advance the field of xenotransplantation toward clinical trials, buoyed by the continued promising outcomes observed in preclinical trials for xenografts 17 . A recent study reviewed xenotransplantation clinical activities as of December 2022, revealing that out of 14 activities, only nine used porcine xenografts 18 .…”
Section: Regulationmentioning
confidence: 99%
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“…Despite the challenges, unwavering efforts are in progress to advance the field of xenotransplantation toward clinical trials, buoyed by the continued promising outcomes observed in preclinical trials for xenografts 17 . A recent study reviewed xenotransplantation clinical activities as of December 2022, revealing that out of 14 activities, only nine used porcine xenografts 18 .…”
Section: Regulationmentioning
confidence: 99%
“…In South Korea, donor αGal‐knockout ‐based transgenic pig kidneys were utilized, featuring knock‐in genes of CD39, CD46, CD55, CD73, and thrombomodulin, along with two to four additional transgenic modifications. These modifications were tested in a non‐human primate (NHP) model, and the grafts demonstrated survival for a median duration of 39 days, with the longest survival lasting 115 days 17 …”
Section: Modifications To the Xenograftmentioning
confidence: 99%