Current status on prevention and treatment of canine leishmaniasis

Reguera, Rosa M.; Morán, Miguel Ángel Olego; Pérez-Pertejo, Yolanda; Garcı́a-Estrada, Carlos; Balaña‐Fouce, Rafael

doi:10.1016/j.vetpar.2016.07.011

Cited by 107 publications

(94 citation statements)

References 222 publications

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“…In addition, CVL features a large contingent of infected animals with cutaneous parasitism, which in its time serve as a source of infection for insect vectors (Reguera et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Rocha

Ribeiro

et al. 2018

Braz. J. Biol.

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Zoonotic visceral leishmaniasis (ZVL), caused by protozoans of the genus Leishmania, it is a worldwide of great importance disease. In the northeast region of Brazil, the state of Alagoas has an endemic status for ZVL. Thus, this work aimed to analyze the epidemiological situation of human and canine visceral leishmaniasis in Alagoas, Northeast, Brazil, from 2007 to 2013. We conducted a descriptive, observational, retrospective study using secondary data from the Notifiable Diseases Information System, the Center of Zoonosis Control of Maceió, and the Central Laboratory of Public Health of Alagoas. During the studied period, it was observed that the highest incidence of human visceral leishmaniasis was in 2011 and the lowest in 2013. On the other hand, canine visceral leishmaniasis had its highest incidence in 2007 and its lowest in 2012. Of the 55 municipalities in the State of Alagoas that showed human visceral leishmaniasis (HVL), São José da Tapera presented an average of 4.4 cases over the past five years, being classified as of intense transmission. Regarding canine visceral leishmaniasis, in the same studied period, 45,112 dogs were examined in the State, of which 4,466 were positive. It resulted, thus, in a 9.9% positivity rate. Conclusions: Our data are important because canine infection is an important risk factor for the human disease. Keywords

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“…In addition, CVL features a large contingent of infected animals with cutaneous parasitism, which in its time serve as a source of infection for insect vectors (Reguera et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Rocha

Ribeiro

et al. 2018

Braz. J. Biol.

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“…It is transmitted during the blood meal feeding of female phlebotomine sandflies, among which Lutzomyia longipalpis is the most important in Brazil; notwithstanding, other arthropods have been reported as potential vectors of this disease (COUTINHO et al, 2005;REGUERA et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…During the transmission cycle, dogs are the main domestic reservoir and their role is considered essential to the increase of the disease in endemic regions (SAVANI et al, 2003;SANTOS et al, 2005;SILVA et al, 2005;REGUERA et al, 2016). Uruguaiana city, in the Brazilian southern state of Rio Grande do Sul, have notifications of positive canine cases and the vector presence since 2009, being classified by the State Center for Health Surveillance as a transmission area of canine visceral leishmaniasis (CVL).…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated to canine visceral leishmaniasis in Uruguaiana city, Brazil

Escobar

Döwich

Zuravski

et al. 2018

SCA

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The present study aimed to evaluate factors associated with canine visceral leishmaniasis (CVL) in areas with higher seroprevalence of it in Uruguaiana city, Rio Grande do Sul state, Brazil, during the year of 2012. A semi-structured questionnaire with socioeconomic and environmental questions was applied in Leishmania endemic regions of the city. The survey data were analyzed by multivariate statistics and the associations between them were presented as odds ratio within a 95% confidence limit. The relationships between the studied variables showed no statistically significant difference between the dwellings with positive and negative dogs. However, when analyzing the odds ratio, the presence of green areas larger than 10m² turned the house into an area of potential risk for CVL (OR= 2.53). There was no difference among the socioeconomic variables education and income, though the groups with lower education and income showed a higher seroprevalence of CVL. The city of Uruguaiana is already located within the CVL broadcasting area and is taken as an endemic region of the disease, with seropositive dogs in all neighborhoods. Thus, the determinants for an increased Leishmania sp. infection could not be indicated, even so, the maintenance of green areas around the households represented a risk factor for being a potential vector shelter. Key words: Neglected disease. Epidemiology. Environment. Socioeconomic factors. ResumoO objetivo da presente pesquisa foi avaliar potenciais fatores de risco associados à ocorrência de leishmaniose visceral canina (LVC) em áreas de maior prevalência no município de Uruguaiana/RS, no ano de 2012. Foram aplicados questionários semiestruturados com questões socioeconômicas e ambientais em bairros endêmicos para LVC no município de Uruguaiana. Os dados foram analisados por meio de análise multivariada e as associações entre as variáveis foram expressas em odds ratio com intervalos de confiança de 95%. As relações entre as variáveis estudadas não apresentaram diferença estatística significativa quando se comparou residências com cães positivos àquelas com cães negativos. Entretanto, a presença de área verde maior que 10m² apresentou-se como um potencial fator de risco (OR= 2,53) para LVC. Não houve diferença significativa entre as variáveis socioeconômicas, escolaridade e renda embora, nos grupos de menor escolaridade e de menor renda familiar, tenha havido

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“…L. infantum has been identified as a major, potentially fatal, zoonotic infection in regions of Europe, Africa, Asia and America (Gramiccia and Gradoni, 2005), although other species such as L. chagasi, L. mexicana, L. braziliensis, L. donovani or L. amazonensis are also potential etiologic agents (Lainson and Shaw, 2005;Alvar et al, 2004). Due to their close association with people, dogs are considered the main reservoir of human infection and phlebotomine sand flies are the biological vectors of this protozoal disease (Reguera et al, 2016;Baneth et al, 2008).…”

Section: Clinical Signs In Canine Leishmaniasismentioning

confidence: 99%

“…Vaccines can adequately boost the immunological system against a potential infection, thus avoiding the toxicity of chemotherapy and the emergence of resistant strains. However, prevention of CanL also involves reducing exposure to vectors using formulations with repellent/insecticide activity such us a large number of insecticide containing deltamethrin or combination of permethrin and neonicotinoid insecticide (Reguera et al, 2016).…”

Section: Prevention (Or Preventive Measures)mentioning

confidence: 99%

Natural Substances as New Potential Strategies for the Treatment of Leishmaniosisin Dogs

Vito¹,

Owen²,

Poapolathep³

et al. 2017

American Journal of Animal and Veterinary Sciences

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Leishmaniasis is a disease caused by the protozoan parasites Leishmania, infecting numerous mammal species. Canine leishmaniasis is potentially zoonotic and causes severe fatal disease in dogs. The discovery of new natural products extracted from medicinal plants or compounds derived from them, such as quercetin, hesperidin, vitamin c, horse chestnut extract and selenium could represent a valuable source of new medicinal agents for treating leishmaniasis in dogs.

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Current status on prevention and treatment of canine leishmaniasis

Cited by 107 publications

References 222 publications

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Risk factors associated to canine visceral leishmaniasis in Uruguaiana city, Brazil

Natural Substances as New Potential Strategies for the Treatment of Leishmaniosisin Dogs

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