Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

Peluso, G.; Incollingo, Paola; Calogero, Armando; Tammaro, Vincenzo; Rupealta, Niccolò; Chiacchio, Gaetano; Sotelo, Maria Laura Sandoval; Minieri, Gianluca; Pisani, Antonio; Riccio, Eleonora; Sabbatini, Massimo; Bracale, Umberto Marcello; Dodaro, Concetta Anna; Carlomagno, Nicola

doi:10.1155/2017/2605628

Cited by 38 publications

(29 citation statements)

References 91 publications

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“…Establishing a personalized therapy in the early stages of tumors with similar histopathological features is a challenge for clinicians, and in this context the correlation of expression of these two molecules brings important information. Also, in these tumors, localization of these two molecules IR indicates, according to literature studies, a good response to 5-FU therapy [17,26,37,38].…”

Section: Tabel 4a Comparison Between Maspin Membrane Ir Andmentioning

confidence: 58%

Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Onofrei¹,

Cotrutz²,

Botez³

et al. 2019

Rev. Chim.

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The results of the recent years researches support the need for personalized therapeutic of cancer by completing the clinical, imagistic and histopathological diagnosis with molecular studies to identify new useful biomarkers for diagnosis, prognosis and tumor progression. Maspin is a non-inhibitory serine protease having a proapoptotic activity, suppressor of tumor invasion, metastasis and angiogenesis. Ezrin is a member of Ezrin/Radixin/Moesin (ERM) family, involved in cellular adhesion mechanisms, motility and invasiveness of tumor cells. In colorectal tumors, there is a heterogeneity of research results regarding the clinical significance of the maspin due to a possible partnership with other molecules with which it interacts through the same signaling pathways. Our study investigated the two molecule�s immunoreactivity (IR) in 92 colorectal tumors highlighting an inverse correlation between ezrin�s and maspin�s expression, suggesting the fact that ezrin�s overexpression could influence maspin�s tumoral suppressor role. Furthermore there was observed a difference of the molecules IR within the same tumoral stage, suggesting their utility regarding the treatment protocol of these tumors.

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Section: Tabel 4a Comparison Between Maspin Membrane Ir Andmentioning

confidence: 58%

Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Onofrei¹,

Cotrutz²,

Botez³

et al. 2019

Rev. Chim.

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“…Data are presented as mean ± standard deviation. Statistical analyses between two groups were performed using Student's t-test via SPSS 16.0. Statistical analyses between multiple groups were performed using one-way analysis of variance (ANOVA) followed by the least significant difference post-hoc test.…”

Section: Discussionmentioning

confidence: 99%

Zinc finger of the cerebellum 5 promotes colorectal cancer cell proliferation and cell cycle progression through enhanced CDK1/CDC25c signaling

et al. 2021

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Introduction: Colorectal cancer (CRC), mostly caused by external or environmental factors, is the third most common and lethal cancer worldwide. Although a large number of investigations have been carried out to reveal the evolution of CRC, the underlying mechanisms of CRC remain unclear. Material and methods: Expression of zinc finger of the cerebellum 5 (ZIC5) in CRC tissues and cell models was measured by qRT-PCR and IHC. Cell transfection was carried out for ZIC5 overexpression or knockdown. The MTT assay was applied to examine the capacity of glioma cell proliferation. Wound healing assay and tumor invasion assay were used to test the capacity of glioma cell migration and invasion respectively. Cell cycle analysis and western blot were used to verify the apoptosis rates of CRC cells upon ZIC5 overexpression or downregulation. A further tumor Xenograft study was used to examine the effects of ZIC5 on tumor malignancy in vivo. Results: Cell models using HCT116 and SW620 cells were established to study the ZIC5 function upon ZIC5 overexpression of knockdown. Consistently, we discovered that ZIC5 also significantly increased in Chinese CRC patients. In addition, ZIC5 promoted CRC cell proliferation through increasing the proportion of cells maintained in the S phase. ZIC5 overexpression facilitated the capacity of CRC cell migration and invasion. Inhibition of ZIC5 mitigated such malignant effects. Conclusions: Collectively, investigations of the ZIC5 in CRC provided a new insight into CRC diagnosis, treatment, prognosis and next-step translational therapeutic developments from bench to clinic.

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“…Molecular biomarkers are promising candidates for predicting treatment response at an early time point with sufficient sensitivity and specificity, since clinical biomarkers are not commonly in use. Although several predictive and prognostic biomarkers for CRC have been reported [7][8][9][10][11][12][13], none to date have been successfully implemented in a clinical setting, and the search for effective molecular predictors continues.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Expression of RAD52, Its Prognostic Impact in Rectal Cancer and Association with Poor Survival of Patients

Chung

Singh

et al. 2020

IJMS

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The DNA damage response enables cells to survive and maintain genome integrity. RAD52 is a DNA-binding protein involved in the homologous recombination in DNA repair, and is important for the maintenance of tumour genome integrity. We investigated possible correlations between RAD52 expression and cancer survival and response to preoperative radiotherapy. RAD52 expression was examined in tumour samples from 179 patients who underwent surgery for rectal cancer, including a sub-cohort of 40 patients who were treated with neoadjuvant therapy. A high score for RAD52 expression in the tumour centre was significantly associated with worse disease-free survival (DFS; p = 0.045). In contrast, reduced RAD52 expression in tumour centre samples from patients treated with neoadjuvant therapy (n = 40) significantly correlated with poor DFS (p = 0.025) and overall survival (OS; p = 0.048). Our results suggested that RAD52 may have clinical value as a prognostic marker of tumour response to neoadjuvant radiation and both disease-free status and overall survival in patients with rectal cancer.

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Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

Cited by 38 publications

References 91 publications

Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Zinc finger of the cerebellum 5 promotes colorectal cancer cell proliferation and cell cycle progression through enhanced CDK1/CDC25c signaling

Aberrant Expression of RAD52, Its Prognostic Impact in Rectal Cancer and Association with Poor Survival of Patients

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