Current Treatment Modalities for Osteonecrosis of Femoral Head in Mainland China: A Cross‐Sectional Study

Abstract

Objective: To investigate the application of treatment modalities for patients with osteonecrosis of the femoral head (ONFH) in mainland China. Methods: This cross-sectional study was based on the online application of China Osteonecrosis of the Femoral Head Database (CONFHD). Between July 2016 to December 2018, the CONFHD program planned to recruit ONFH patients from 12 administrative areas across mainland China. Real-world medical records of treatment regimens for these patients, including surgeries and prescriptions, were approved to upload to the CONFHD application for further analysis. The surgeries performed on these patients were classified into total hip arthroplasty and hip-preserving procedures, and the latter was further classified into core decompression, bone grafting, and tantalum rod implantation. Prescription medications were classified into chemical medicine and Chinese herbal medicine (CHM); chemical medicine was further classified according to their chemical compounds, and CHM was classified according to therapeutic functions based on traditional Chinese medicine theory. Descriptive analysis was performed to summarize the application of different treatment regimens on the overall sample.

General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19

“…Finally, 15 articles (Appendix Ref. [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] ]) were selected for the following meta-analysis. The article selection process was illustrated in Figure A3 a.…”

“…Of the 15 studies, 9 (Appendix Ref. [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] ]) and 6 (Appendix Ref. [ [10] , [11] , [12] , [13] , [14] , [15] ]) were published in Chinese and English, respectively.…”

“…Accumulating clinical studies showed that osteonecrosis more frequently occurs in the femoral head, the incidence of ONFH among convalescent SARS patients was calculated based on 14 studies (Appendix Ref. [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [13] , [14] , [15] ]) in our meta-analysis. The article selection process was illustrated in Figure A4 a. Randomized effect model meta-analysis indicated a combined proportion at 28.8% (95% CI:20.7%–37.0%, Fig.…”

“…However, glucocorticoid exposure may lead to the occurrence of osteonecrosis [ 4 ], which is characterized by the loss of blood supply to the subchondral bone at multiple joints, such as hip, knee, shoulder, and ankle [ 5 ]. Due to joint destruction and disability rapidly caused by osteonecrosis, most patients will undergo long-term medical interventions or repeated surgeries throughout their lifespan [ 6 , 7 ].…”

Application of protective weight-bearing in osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials and observational studies

“…Osteonecrosis of the femoral head (ONFH) is a destructive disease of the joint that often severely affects the patient's function and reduces the quality of life ( 1 ). In China, an estimated 8.12 million patients are older than age 15 ( 2 ).…”