Current trend on preparation, characterization and biomedical applications of natural polysaccharide-based nanomaterial reinforcement hydrogels: A review

Najihah, A.Z.; Hassan, Mohamad Zaki; Ismail, Zarini

doi:10.1016/j.ijbiomac.2024.132411

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.132411

|View full text |Cite

Current trend on preparation, characterization and biomedical applications of natural polysaccharide-based nanomaterial reinforcement hydrogels: A review

A.Z. Najihah,

Mohamad Zaki Hassan,

Zarini Ismail

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 250 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Sol–gel surface modification of selective laser melting Ti6Al4V for biomedical applications

Aufa,

Hassan,

Ismail

et al. 2024

Prog Addit Manuf

View full text Add to dashboard Cite

Sol–gel surface modification of selective laser melting Ti6Al4V for biomedical applications

Aufa,

Hassan,

Ismail

et al. 2024

Prog Addit Manuf

View full text Add to dashboard Cite

Construction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors

Wang,

Nie,

Lin

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Malignant tumors, also known as cancers, are a global public health problem. Nanogels are promising carriers for the delivery of anticancer medicines. Therefore, based on the unique microenvironment of tumor cells and the advantages of nanogels, a simple and economical one-pot synthesis method was designed to construct natural polysaccharide-based redox-responsive nanogels (LDD NGs). The enhanced permeability and retention (EPR) effect enriched LDD NGs in tumor cells, which then rapidly collapsed and released the natural antitumor drug diosgenin (DG) and the natural polysaccharide lentinan (LNT) via the depletion of a high level of reduced glutathione (GSH) in tumor cells, resulting in a synergistic therapeutic effect of chemotherapy and immunotherapy. In vivo antitumor experiments showed that LDD NGs could inhibit the proliferation and metastasis of the A549 lung cancer cells. Further studies indicated that LDD NGs could increase the production of ROS and induce apoptosis of A549 cells. In addition, LNT released from LDD NGs could promote the proliferation of dendritic cells, increase the production of NO, and upregulate the expressions of the costimulatory molecules CD40, CD80, CD86, and MHC-II. The construction of LDD NGs was a novel drug synthesis approach that could provide fresh ideas for the development of polysaccharide-based redox-responsive drug delivery systems.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Current trend on preparation, characterization and biomedical applications of natural polysaccharide-based nanomaterial reinforcement hydrogels: A review

Cited by 2 publications

References 250 publications

Sol–gel surface modification of selective laser melting Ti6Al4V for biomedical applications

Sol–gel surface modification of selective laser melting Ti6Al4V for biomedical applications

Construction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors

Contact Info

Product

Resources

About