Current Trends and Future Perspectives of Hydrogen Sulfide Donors

Abstract

Hydrogen sulfide (H2S) gas is included to be the most critical endogenous gasotransmitters that has several pathophysiological effects in many human cells and organ tissues. The synthesis of endogenous H2S in cells via several pathways. Variant biological effects of H2S including ion channel regulation, redox regulation of protein, thiols, polysulfides, thiosulfate/sulfite, and anti-oxidant activities affecting many cellular and molecular reactions. Therefore, it is essential to review H2S chemical biology, methods of detection of H2S release and its effects on pathological and physiological functions along with their therapeutic uses, including cardiovascular protective activities, anti-inflammatory and anti-tumor activities of the H2S donors.

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

“…Certain probes, which have been described in detail, use nitro or azide derivatives of rhodamine, dansyl, coumarins or naphthylamides, which can be reduced by H2S to produce fluorescent amines (Figure 34). In chemical synthesis, H2S is frequently used for the reduction of azido groups (N3) [183] and aromatic nitro groups [184] to aniline derivatives due to its strong reducing agent properties.…”

“…Using a similar strategy, Wang's lab has developed a sulfonyl azidedansyl derivative, whose electrical and fluorescent properties are due to the different electronegativity of the azide and amine groups. H2S could be captured with a fluorescent In chemical synthesis, H 2 S is frequently used for the reduction of azido groups (N 3 ) [183] and aromatic nitro groups [184] to aniline derivatives due to its strong reducing agent properties.…”