Current Trends and Research Hotspots in Pancreatic Stellate Cells: A Bibliometric Study

Yang, Zhuqiang; Xie, Zhihui; Wan, Jian; Yang, Bo; Xu, Tao; Shu, Xu; Zhao, Zhong-Qiu; Tang, Caixi

doi:10.3389/fonc.2022.896679

Cited by 5 publications

(6 citation statements)

References 64 publications

(69 reference statements)

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“…These results reflected that the United States had made great contributions and established its leading position in the field of NDDS for PC. In addition to the research topic of NDDS for PC, similar results were also obtained in the bibliometric analysis of other topics such as “pancreatic cancer” ( Wang and Herr, 2022 ), “pancreatic stellate cells” ( Yang et al, 2022b ), and “inhalable nanosystems” ( Huang et al, 2021 ). As for the cooperation among countries, it could be seen from Figure 3C that among the 20 countries with the most publications, the United States and China had the closest cooperation with other countries/regions; The United States, European countries (e.g., Italy and France), and Asian countries (e.g., China, India, and Saudi Arabia) were still the most important parts of the national cooperation landscape, and extensive cooperation had been established between them, but the cooperation of other developing countries was still relatively weak, and these countries needed to further cooperate to promote the development of NDDS for PC research field worldwide.…”

Section: Discussionsupporting

confidence: 62%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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Background: Nano drug delivery system (NDDS) can significantly improve the delivery and efficacy of drugs against pancreatic cancer (PC) in many ways. The purpose of this study is to explore the related research fields of NDDS for PC from the perspective of bibliometrics.Methods: Articles and reviews on NDDS for PC published between 2003 and 2022 were obtained from the Web of Science Core Collection. CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel were comprehensively used for bibliometric and visual analysis.Results: A total of 1329 papers on NDDS for PC were included. The number of papers showed an upward trend over the past 20 years. The United States contributed the most papers, followed by China, and India. Also, the United States had the highest number of total citations and H-index. The institution with the most papers was Chinese Acad Sci, which was also the most important in international institutional cooperation. Professors Couvreur P and Kazuoka K made great achievements in this field. JOURNAL OF CONTROLLED RELEASE published the most papers and was cited the most. The topics related to the tumor microenvironment such as “tumor microenvironment”, “tumor penetration”, “hypoxia”, “exosome”, and “autophagy”, PC treatment-related topics such as “immunotherapy”, “combination therapy”, “alternating magnetic field/magnetic hyperthermia”, and “ultrasound”, and gene therapy dominated by “siRNA” and “miRNA” were the research hotspots in the field of NDDS for PC.Conclusion: This study systematically uncovered a holistic picture of the performance of NDDS for PC-related literature over the past 20 years. We provided scholars to understand key information in this field with the perspective of bibliometrics, which we believe may greatly facilitate future research in this field.

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Section: Discussionsupporting

confidence: 62%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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“…Macrophages are demonstrated to be the frontline response within the immune system to instances of infection and injury ( 135 ). Monocytes make their way to the site of inflammation via VCAM-1/VLA-4 binding and CCR2/CCL2 migration ( 136 ). In addition to migratory monocytes, resident tissue macrophages simultaneously respond to initial insults.…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target

Hartupee,

Nagalo,

Chabu

et al. 2024

Front. Immunol.

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Pancreatic Ductal Adenocarcinoma (PDAC) is projected to become the 2nd leading cause of cancer-related deaths in the United States. Limitations in early detection and treatment barriers contribute to the lack of substantial success in the treatment of this challenging-to-treat malignancy. Desmoplasia is the hallmark of PDAC microenvironment that creates a physical and immunologic barrier. Stromal support cells and immunomodulatory cells face aberrant signaling by pancreatic cancer cells that shifts the complex balance of proper repair mechanisms into a state of dysregulation. The product of this dysregulation is the desmoplastic environment that encases the malignant cells leading to a dense, hypoxic environment that promotes further tumorigenesis, provides innate systemic resistance, and suppresses anti-tumor immune invasion. This desmoplastic environment combined with the immunoregulatory events that allow it to persist serve as the primary focus of this review. The physical barrier and immune counterbalance in the tumor microenvironment (TME) make PDAC an immunologically cold tumor. To convert PDAC into an immunologically hot tumor, tumor microenvironment could be considered alongside the tumor cells. We discuss the complex network of microenvironment molecular and cellular composition and explore how they can be targeted to overcome immuno-therapeutic challenges.

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“…It is a comprehensive knowledge system that integrates mathematics, statistics, and philology and focuses on quantification. In today's big data era, bibliometrics can help scientists and clinicians sort out the research context and hotspots in a certain research field, predict research trends, and greatly improve their research efficiency (9,10). Up to now, there are many bibliometric articles related to pancreatic cancer have been published, mainly on the tumor microenvironment (11), stellate cells (12), nanoparticles (13), clinical trials (14), pancreatic cancer in the Middle East and North Africa (15), and machine learning for pancreatic cancer (16), pancreatic neuroendocrine tumors (17), etc.…”

Section: Introductionmentioning

confidence: 99%

Emerging current trends and research focus related to pancreatic cancer metabolism: A bibliometric and visualized analysis

Shen

Zhang²,

Jiang³

et al. 2022

Front. Oncol.

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BackgroundAs a malignant digestive system tumor, pancreatic cancer has unique metabolic characteristics. In recent years, the study of pancreatic cancer metabolism is in full swing, which provides a new direction for the treatment of pancreatic cancer patients. However, there is no systematic report of pancreatic cancer metabolism. In this paper, bibliometrics and visualization methods were used to analyze the number of publications, countries/regions, authors, institutions, journals, co-cited references, and keywords of pancreatic cancer metabolism articles, to summarize the research trends and predict research hotspots.MethodsWe searched, screened and downloaded articles on pancreatic cancer metabolism through the Web of Science Core Collection (WoSCC). Using CiteSpace, VOSviewer and Bibliometrix Package to analyze publications, countries/regions, authors, institutions, journals, co-cited references, and keywords of pancreatic cancer metabolism to identify research trends and predict research hotspots.ResultsAccording to the inclusion and exclusion criteria, a total of 5,255 articles were retrieved during the period 1943-2022. The number of publications on pancreatic cancer metabolism is increasing year by year. The United States (n=1602, 30.49%), China (n=1074, 20.44%), and Italy (n=313, 5.96%) are the three countries with the largest number of publications and citations, and there is close cooperation between countries. LI J (n=55) is the most prolific author. FUDAN UNIV (n=348) is the most published institution. CANCERS (n=118), PLOS ONE (n=93), and CANCER RESEARCH (n=80) are the most popular journals in this field. “Nutriment-deficient environment”, “cancer chemoprevention” and “targeting cancer stem cell” are the main areas of focus. “immunotherapy”, “ferroptosis” and “targeted therapy” are hot keywords in recent years. Taking pancreatic cancer metabolism as an entry point to study the role of traditional Chinese medicine (TCM) mainly focuses on curcumin and resveratrol, lack of broader and deeper research on TCM.ConclusionsThe number of publications on pancreatic cancer metabolism has generally increased, and scholars have generally paid more attention to this field. “immunotherapy”, “ferroptosis” and “targeted therapy” are the current research hotspots. The in-depth study of pancreatic cancer metabolism will provide new ideas for the treatment of pancreatic cancer.

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Current Trends and Research Hotspots in Pancreatic Stellate Cells: A Bibliometric Study

Cited by 5 publications

References 64 publications

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target

Emerging current trends and research focus related to pancreatic cancer metabolism: A bibliometric and visualized analysis

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