Current trends in polymer microneedle for transdermal drug delivery

AL-Japairai, Khater Ahmed Saeed; Mahmood, Syed; Almurisi, Samah Hamed; Venugopal, Jayarama Reddy; Hilles, Ayah Rebhi; Azmana, Motia; Raman, Subashini

doi:10.1016/j.ijpharm.2020.119673

Cited by 235 publications

(115 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HA is a natural linear polysaccharide with excellent water solubility, biocompatibility, biodegradability, and mechanical properties, which has been used extensively in the fabrication of MN [ 58 , 59 , 60 ]. However, dissolving MNs prepared only by HA have high fragility, whereas PVP-K90 is a polymer with good toughness and hardness [ 30 , 61 , 62 ]. Thus, PVP-K90 was used to adjust the mechanical strength and fragility of the MNs.…”

Section: Resultsmentioning

confidence: 99%

“…Following insertion into the skin, the needles dissolve upon imbibing water from the interstitial fluids and release the drug payloads. Therefore, drugs are directly delivered into the skin to exert therapeutic effects [ 30 ], while no sharp needles are left behind [ 31 , 32 ]. Moreover, the manufacture of dissolving MNs is comparatively easier than other types of MNs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride

Zhang

Zheng

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Oral propranolol hydrochloride has been the first-line treatment for infantile hemangioma (IH), whereas systemic exposure to propranolol has the potential of causing serious adverse reactions. Dermal delivery of propranolol is preferable due to high local drug concentration and fewer adverse effects. However, propranolol hydrochloride (BCS class I) is highly hydrophilic and has difficulty in penetrating the stratum corneum (SC) barrier. Dissolving microneedles (MNs) are an efficient tool for overcoming the barrier of the SC and enhancing dermal drug delivery. In this study, propranolol hydrochloride-loaded dissolving MNs were fabricated by using hyaluronic acid and polyvinyl pyrrolidone as matrix materials. Controllable drug loading in needle tips was achieved by a two-step casting procedure. The needles were good in mechanical strength for penetrating the SC while presented excellent dissolving capability for releasing propranolol hydrochloride. In comparison with the solution counterpart, irrespective of being applied to intact skin or solid MNs-pretreated skin, dissolving MNs significantly increased the permeability and skin retention of propranolol. In conclusion, dissolving MNs could be a potential approach for enhancing dermal delivery of propranolol to treat IH.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride

Zhang

Zheng

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Polymeric microneedle arrays are particularly helpful for the administration of proteins, drugs, vaccines, and DNA. Polymer-based microneedles have swelling and dissolving properties with a polymer crosslinking network structure and hydrophilic characteristics [ 44 , 48 , 49 ]. Using the materials discussed above, microneedles can be fabricated to deliver drugs through various strategies.…”

Section: Microneedles-based Transdermal Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies

Mdanda¹,

Ubanako²,

Kondiah³

et al. 2021

Polymers

View full text Add to dashboard Cite

In many clinical applications, the transdermal route is used as an alternative approach to avoid the significant limitations associated with oral drug delivery. There is a long history for drug delivery through the skin utilizing transdermal microneedle arrays. Microneedles are reported to be versatile and very efficient devices. This technique has spurred both industrial and scientific curiosity, due to its outstanding characteristics such as painless penetration, affordability, excellent medicinal efficiency, and relative protection. Microneedles possess outstanding properties for diverse biomedical uses such as the delivery of very large substances with ionic and hydrophilic physicochemical properties. Importantly, microneedles are applicable in numerous biomedical fields such as therapy, diagnosis, and vaccine administration. Microneedles are emerging tools that have shown profound potential for biomedical applications. Transdermal microneedle technologies are likely to become a preferred route of therapeutic substances administration in the future since they are effective, painless, and affordable. In this review, we summarize recent advances in microneedles for therapeutic applications. We explore their constituent materials and fabrication methods that improve the delivery of critical therapeutic substances through the skin. We further discuss the practicality of advanced microneedles used as drug delivery tools.

show abstract

“…In patterning very high-aspect-ratio polymer structures, friction force may dominate and lead to low yield, which presents a great challenge in creating very high-aspect-ratio polymer structures for specific applications such as polymeric microneedles for drug delivery. Although metal, glass, silicon, and ceramics are also fabricated as microneedles, the rigid piece may break inside the skin, causing pain and possibly swelling of the skin [ 131 ]. On the contrary, polymers are preferred, because they absorb water into the polymeric network, leading to swelling of the microneedle and intact removal from the skin [ 132 ].…”

Section: Interaction Forces Between Mold and Resist During Demoldingmentioning

confidence: 99%

Interfacial Interactions during Demolding in Nanoimprint Lithography

Chen

Luo

et al. 2021

Micromachines

View full text Add to dashboard Cite

Nanoimprint lithography (NIL) is a useful technique for the fabrication of nano/micro-structured materials. This article reviews NIL in the field of demolding processes and is divided into four parts. The first part introduces the NIL technologies for pattern replication with polymer resists (e.g., thermal and UV-NIL). The second part reviews the process simulation during resist filling and demolding. The third and fourth parts discuss in detail the difficulties in demolding, particularly interfacial forces between mold (template) and resist, during NIL which limit its capability for practical commercial applications. The origins of large demolding forces (adhesion and friction forces), such as differences in the thermal expansion coefficients (CTEs) between the template and the imprinted resist, or volumetric shrinkage of the UV-curable polymer during curing, are also illustrated accordingly. The plausible solutions for easing interfacial interactions and optimizing demolding procedures, including exploring new resist materials, employing imprint mold surface modifications (e.g., ALD-assisted conformal layer covering imprint mold), and finetuning NIL process conditions, are presented. These approaches effectively reduce the interfacial demolding forces and thus lead to a lower defect rate of pattern transfer. The objective of this review is to provide insights to alleviate difficulties in demolding and to meet the stringent requirements regarding defect control for industrial manufacturing while at the same time maximizing the throughput of the nanoimprint technique.

show abstract

Current trends in polymer microneedle for transdermal drug delivery

Abstract: Graphical abstract Polymer microneedle promotes the delivery of chemical and biological drugs through the skin.

Cited by 235 publications

References 168 publications

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride

Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies

Interfacial Interactions during Demolding in Nanoimprint Lithography

Contact Info

Product

Resources

About