Current Trends in Simultaneous Determination of Co-Administered Drugs

Celia, Christian; Marzio, Luisa Di; Locatelli, Marcello; Ramundo, P.; D'Ambrosio, Francesca Romana; Tartaglia, Angela

doi:10.3390/separations7020029

Cited by 9 publications

(3 citation statements)

References 104 publications

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“…As a result, therapeutic drug monitoring (TDM) is frequently necessary to decrease toxicity, boost clinical efficacy, and prevent the development of antimicrobial resistance. For the greatest conceivable patient benefit, this monitoring tries to maintain medication levels in plasma or blood within a specific therapeutic range (35,36).…”

Section: Molecular Formula: C16h14f3n3o2smentioning

confidence: 99%

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Darweish

Fayez

Marzouk

et al. 2023

ERU Research Journal

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In order to encourage and facilitate collecting literature review for other researchers who will have studies related to the presented compounds, the following article was introduced by presenting a mini-review of the different methods applied for quantitative determination of some drugs affecting GIT namely, Lansoprazole (LAN) co-formulated with Clarithromycin (CLR) and Tinidazole (TD), and Phloroglucinol (PHG) and Trimethylphloroglycinol (TMG) combination, in their drug mixture forms using different analytical techniques. Helicobacter pylori (H. Pylori) is a fairly prevalent infection that disrupts the stomach, causing several annoyances signs such as chronic gastritis, peptic ulcers, and gastric cancer. Lately, it has been shown that COVID-19 patients' gastrointestinal symptoms are negatively impacted by H. Pylori infection. An effective triple therapy regimen, which typically includes antibiotics and stomach protection, is required to eradicate this bacterial infection. This study discussed the pharmacopeia methods applied for the studied drugs in addition to different techniques which were used for simultaneous determination of the presented compounds in their mixture formulations; including spectrophotometric (UV and visible), electrochemical, in addition to chromatographic (TLC and HPLC) methods either in a biological fluid or in their pharmaceutical dosage forms. All the discussed approaches in this review were applied and ERURJ 2023, 2, 2, 222 -236 223 validated following the ICH guidelines. Some of these methods were accomplished according to the green chemistry and evaluated with the green assessment approaches.

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Section: Molecular Formula: C16h14f3n3o2smentioning

confidence: 99%

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Darweish

Fayez

Marzouk

et al. 2023

ERU Research Journal

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“…The development of a common HPLC method saves time and solvents and increases the rate of routine analysis of different batches of formulations. The use of the same HPLC column and solvents reduces the time required to attain equilibrium between the stationary and mobile phases [40,41]. Hence, in the present work, a simple RP-HPLC method has been established and validated using the same reverse-phase high-performance liquid chromatography (RP-HPLC) column and mobile phase for the analysis of amlodipine and/or hydrochlorothiazide with different sartans.…”

Section: Introductionmentioning

confidence: 99%

A Rapid HPLC Method for the Concurrent Determination of Several Antihypertensive Drugs from Binary and Ternary Formulations

et al. 2021

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A rapid, synchronized liquid chromatographic method was established for the estimation of hydrochlorothiazide (HCZ), amlodipine (AMD), olmesartan (OLM), telmisartan (TEL), and irbesartan (IRB) in binary and ternary coformulations using the same chromatographic conditions. Five analytes were separated on a Zorbax C18 column using isocratic elution with a mobile phase consisting of acetonitrile, methanol, and 20 mM phosphate buffer (pH 3.5) in a ratio of 45:20:35% v/v. The analytes were detected at a wavelength of 230 nm at ambient temperature. Furthermore, the proposed liquid chromatographic procedure was validated for linearity, precision, accuracy, stability, and robustness using an experimental design. Analytes were separated with good resolution within 3.5 min. Analytes showed good linearity in a concentration satisfactory to analyze the different ratios of these analytes in the formulations. Pareto charts showed that the flow rate and mobile phase composition have a significant effect on the peak area of analytes and hence need to be carefully controlled, however, the method is robust. Finally, the different formulations consisting of HCZ, AMD, OLM, TEL, and IRB in different ratios were analyzed with high accuracy using an optimized HPLC method and compared with reported methods. Furthermore, the reported HPLC procedure is simple, rapid, and accurate and therefore can used for regular quality control of binary and ternary formulations using the same stationary and mobile phase.

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“…To indicate the importance of this work, we begin with the literature review that summarizes the different analytical methods used previously for the determination of aspirin and omeprazole as a binary mixture such as spectrophotometry (Khan, Bandewar, Zameeruddin, & Bharkad, 2017), high‐performance liquid chromatography (Kamal, Marie, & Hammad, 2020; Nassar, Attia, Mohamed, & Shahin, 2017; Patel, Patel, & Shah, 2018; Patta, Afreen, Tappa, Nagarajan, & GnanaPrakash, 2017; Salomi, Purushothaman, & Satyanarayana, 2019; Sarode & Jadhav, 2018; Yenduri & Navuluri, 2018), and thin‐layer liquid chromatography (Kashid & Kolhe, 2019; Nassara, Attiaa, Mohamed, & Shahinb, 2018). Omeprazole was determined as binary drug‐association co‐formulation in tablets using high‐performance liquid chromatography (HPLC) (Celia et al, 2020). Aspirin was also determined with other drugs and in the presence of salicylic acid using HPLC (Dongala, Katari, Palakurthi, & Jonnalagadda, 2019).…”

Section: Introductionmentioning

confidence: 99%

Green analysis of newly approved binary omeprazole/aspirin mixture in presence of aspirin impurity using ultra‐high‐performance liquid chromatography and thin‐layer chromatography methods

Abdelaleem

Ella

Mahmoud

et al. 2020

Biomedical Chromatography

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Two green, simple, and accurate chromatographic methods were developed and validated for the simultaneous determination of omeprazole and aspirin mixture in the presence of salicylic acid, a major impurity of aspirin. Method A is a reversed‐phase ultra‐high‐performance liquid chromatography; the separation was performed on a C18 column, with a mobile phase composed of ethanol:0.1% aqueous solution of triethylamine acidified with orthophosphoric acid (pH 3) (30:70, v/v) at 0.15 mL/min flow rate and 230 nm. Omeprazole, aspirin, and aspirin impurity retention times were 7.47, 4.40, and 5.13 min, respectively. Good linearity was achieved in the concentration ranges of 5–80, 5–85, and 3–50 μg/mL for the three mentioned components, respectively. Method B is thin‐layer chromatography (TLC) where silica gel TLC F254 plates were utilized to achieve separation using ethanol:ethyl acetate (2:8, v/v) as a developing system at 240 nm. The resulted Rf values were 0.83, 0.65, and 0.23 for omeprazole, aspirin, and impurity, respectively. The concentration ranges of 0.1–3 μg/band for the three drugs showed good linearity. The proposed methods are eco‐friendly and greener when compared to the already reported method (Microchemical Journal, 152, 104350). This is the first use of TLC method for the determination of the three drugs. International Council for Harmonization (ICH) guidelines were followed to ensure the validity of developed methods.

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Current Trends in Simultaneous Determination of Co-Administered Drugs

Cited by 9 publications

References 104 publications

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

A Rapid HPLC Method for the Concurrent Determination of Several Antihypertensive Drugs from Binary and Ternary Formulations

Green analysis of newly approved binary omeprazole/aspirin mixture in presence of aspirin impurity using ultra‐high‐performance liquid chromatography and thin‐layer chromatography methods

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