Current trends in the management of posterior urethral valves in the pediatric population

Yohannes, Paulos; Hanna, Moneer K.

doi:10.1016/s0090-4295(02)01621-7

Cited by 75 publications

(57 citation statements)

References 43 publications

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“…It is possible that this association is due to the fact that early diagnosis is often a result of more severe anatomical anomalies. 7,9,17,18 …”

Section: Age At the Time Of Diagnosismentioning

confidence: 99%

“…7,9,[17][18][19] Some researchers postulate the importance of high serum creatinine concentration on the diagnosis of PUV as a negative prognostic factor of developing CKD or nadir serum creatinine concentration after valve ablation.…”

Section: Nadir Serum Creatinine Concentrationmentioning

confidence: 99%

“…It reveals residual urine and vesicoureteral reflux, and is also useful in the assessment of detrusor and bladder neck activity. 7,32 CKD. 22,23 In 2003, Osama demonstrated that when the clearance of creatinine was lower than 60 mL/min/1.73 m 2 , the prognosis for renal failure in the future would be at approximately 50%, while for creatinine clearance above 90 mL/min/1.73 m 2 , the incidence of renal failure would decrease to 27%.…”

Section: Voiding Cystourethrographymentioning

confidence: 99%

“…6 Modern therapeutic procedure involve endoscopic valve ablation (through urethra) shortly after the birth, but in some cases, especially in prenatal babies with too small urethras, temporary vesicostomy may be necessary. 7,8 Even early surgical intervention is usually insufficient, and patients with PUV develop valve bladder syndrome (VBS); in 25-45% CKD will develop eventually. 7 Obstruction of the urine flow resulting from PUV leads to various, sometimes life-threatening consequences ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Even early surgical intervention is usually insufficient, and patients with PUV develop valve bladder syndrome (VBS); in 25-45% CKD will develop eventually. 7 Obstruction of the urine flow resulting from PUV leads to various, sometimes life-threatening consequences ( Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

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Valve bladder syndrome in children: On the trail of the best strategies to prevent chronic kidney disease

Polak−Jonkisz¹,

Rehan²,

Fornalczyk³

et al. 2017

Adv Clin Exp Med

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Pediatric patients suffering from valve bladder syndrome (VBS) are at risk of developing chronic kidney disease (CKD) and renal failure in later life. Therefore, it is of vital importance to determine the risk factors and the best possible strategies for diagnosis and treatment in patients with VBS that would minimize the risk of developing CKD. In this review we have presented the current knowledge of CKD risk factors in patients with posterior urethal value (PUV). We have also discussed possible recommendations for prenatal diagnostics procedures to be undertaken in patients with PUV, postnatal monitoring and therapeutic strategies that could reduce the risk of developing CKD in this population. Although in most cases there are no clear guidelines for appropriate clinical actions that can be undertaken in patients with PUV to minimize the risk of kidney failure, we have tried to present concise and accurate advice for physicians taking care of patients with PUV.

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“…It is possible that this association is due to the fact that early diagnosis is often a result of more severe anatomical anomalies. 7,9,17,18 …”

Section: Age At the Time Of Diagnosismentioning

confidence: 99%

Section: Nadir Serum Creatinine Concentrationmentioning

confidence: 99%

Section: Voiding Cystourethrographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Valve bladder syndrome in children: On the trail of the best strategies to prevent chronic kidney disease

Polak−Jonkisz¹,

Rehan²,

Fornalczyk³

et al. 2017

Adv Clin Exp Med

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Posterior urethral valves

Woodhouse

2015

Adolescent Urology and Long‐term Outcomes

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Rare copy number variants implicated in posterior urethral valves

Boghossian

Sicko

Kay

et al. 2015

American J of Med Genetics Pt A

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The cause of posterior urethral valves (PUV) is unknown, but genetic factors are suspected given their familial occurrence. We examined cases of isolated PUV to identify novel copy number variants (CNVs). We identified 56 cases of isolated PUV from all live-births in New York State (1998–2005). Samples were genotyped using Illumina HumanOmni2.5 microarrays. Autosomal and sex-linked CNVs were identified using PennCNV and cnvPartition software. CNVs were prioritized for follow-up if they were absent from in-house controls, contained ≥10 consecutive probes, were ≥20 Kb in size, had ≤20% overlap with variants detected in other birth defect phenotypes screened in our lab, and were rare in population reference controls. We identified 47 rare candidate PUV-associated CNVs in 32 cases; one case had a 3.9 Mb deletion encompassing BMP7. Mutationsin BMP7 have been associated with severe anomalies in the mouse urethra. Other interesting CNVs, each detected in a single PUV case included: a deletion of PIK3R3 and TSPAN1, duplication/triplication in FGF12, duplication of FAT1—a gene essential for normal growth and development, a large deletion (>2 Mb) on chromosome 17q that involves TBX2 and TBX4, and large duplications (>1 Mb) on chromosomes 3q and 6q. Our finding of previously unreported novel CNVs in PUV suggests that genetic factors may play a larger role than previously understood. Our data show a potential role of CNVs in up to 57% of cases examined. Investigation of genes in these CNVs may provide further insights into genetic variants that contribute to PUV.

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Current trends in the management of posterior urethral valves in the pediatric population

Cited by 75 publications

References 43 publications

Valve bladder syndrome in children: On the trail of the best strategies to prevent chronic kidney disease

Valve bladder syndrome in children: On the trail of the best strategies to prevent chronic kidney disease

Posterior urethral valves

Rare copy number variants implicated in posterior urethral valves

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